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Nitrous oxide, a commonly used analgesic gas, improved temporary opening of the blood-brain barrier (BBB) and gene therapy delivery in mouse models using focused ultrasound (FUS), UT Southwestern Medical Center researchers report in a new study.

– The STING protein, known for helping cells fight viral infections by generating inflammation, also appears to function as a quality control sensor for organelles that serve as cellular waste disposal systems, UT Southwestern Medical Center researchers found. Their study, published in Molecular Cell, helps explain critical features of diseases called lysosomal storage disorders and could eventually lead to new treatments for these and other neurodegenerative diseases.

A new tool called PHOTON, developed by scientists at UT Southwestern Medical Center, can identify RNA molecules at their native locations within cells – providing valuable clues to where different RNA species are distributed spatially in response to various cellular cues.

A grid of electrodes placed on the backs of study participants delivered enough low-voltage electrical stimulation through the skin to change the short-term function of spinal cord neurons, a study led by UT Southwestern Medical Center researchers showed.

Dallas ISD and the UT Southwestern Medical Center (UTSW) together will launch a new transformation school slated to open its doors next fall.

A molecule called glial fibrillary acidic protein (GFAP) rose significantly in the blood of patients who underwent high-intensity focused ultrasound (HIFU), a procedure that is used to treat tremors and causes damage similar to a small stroke, UT Southwestern Medical Center scientists discovered in a new study. Their findings, published in Brain Communications, reveal a potential biomarker for stroke and could eventually lead to blood tests that quickly diagnose brain injuries.

– UT Southwestern, one of the first medical schools in the country to integrate culinary medicine and nutrition education into its curriculum, is partnering with the U.S. Department of Health and Human Services (HHS) and more than 50 other top medical schools to launch a program promoting more widespread, meaningful nutrition training for future doctors.

Multidrug resistance in cancer can be overcome by combining a drug that blocks a key enzyme with another anticancer drug, according to a study in preclinical models led by researchers at UT Southwestern Medical Center. The findings, published in Science Advances, could have implications for patients with certain cancers that have KRAS-G12C mutations after resistance to drug therapy develops.

David Mangelsdorf, Ph.D., Chair and Professor of Pharmacology and Professor of Biochemistry at UT Southwestern Medical Center, has been awarded the Hill Prize in Biological Sciences from the Texas Academy of Medicine, Engineering, Science and Technology (TAMEST) in recognition of his long-standing research on orphan nuclear receptors – proteins in the cell nucleus that flip genes on and off and are triggered by unknown molecules.

Researchers at UT Southwestern Medical Center have linked blindness in animal models to a brain-wide cellular stress response that’s a common risk factor for dementia. Their findings, published in Nature Communications, could help explain the connection between vision or hearing loss and dementia.