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The broad research interest of Fei Wang lab is in dissecting molecular mechanisms of essential cellular events in eukaryotic cell development. Currently, my laboratory investigates how cells preserve the fidelity of gametogenesis under environmental and physiological stress. Gametogenesis, the process by which diploid precursors undergo meiosis and differentiation to produce haploid gametes, is remarkably sensitive to temperature and other stressors. Even mild perturbations tolerated by mitotically dividing cells can disrupt meiosis, leading to infertility or defective gametes. This heightened sensitivity reflects the competing demands faced by germ cells: they must complete complex developmental transitions while responding flexibly to environmental challenges. The mechanisms that safeguard meiotic integrity under such conditions have long remained poorly understood. In somatic cells, two conserved pathways—stress granules (SGs) and autophagy—serve as major quality-control systems under stress. SGs se…

In the Zhang Lab, we seek to understand the molecular mechanisms of metabolic diseases, with the long-term goal of creating novel therapeutic strategies.

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The Osborne Lab focuses on how regulation of miRNA and mRNA controls the branching of developing cells, and how disregulation of these pathways contributes to aggressive tumor behavior.

Goldsmith Lab combines drug discovery and mechanistic analysis to understanding protein kinases. 

Our research is driven by a desire to understand how these microscopic machines both replicate themselves and, at the same time, manage to evade, manipulate, and counter a myriad of host defenses. 

Skip to main content Collaborate Why collaborate with us? By collaborating, we can overcome limitations and conduct more extensive and comprehensive studies. Our internationally recognized team would love to work with you to enhance the quality of our studies by leveraging each other's expertise and …

O'Donnell Lab investigates mechanisms of tumor initiation, progression, and metastasis using molecular and biochemical studies and animal models.

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