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Located in the Department of Ophthalmology, the Wert laboratory studies the post-mitotic neuronal cells of the retina, particularly the photoreceptor cells. Our goal is to discover and understand the mechanisms underlying retinal degenerative disease, and to provide novel therapeutics for these complex degenerative disorders using gene therapy and genome engineering technologies, human stem cell transplantations, and metabolic rescue.

The Moreland and Potera Labs utilize basic science approaches, in vivo models, and clinical studies to investigate cellular functions of the innate immune system.

Our group initially investigated a novel immune checkpoint inhibitor targeting a rare heparan sulfate (rHS) in melanoma treatment. Collaboratively, we explored the potential of a single-domain humanized rHS antibody (1A7 clone) that inhibits DC-HIL function and also angiogenesis and chemokine effects linked to diverse cancer progression signaling pathways. This experience provided insights into rHS-targeting as a promising approach to melanoma therapy.

Meet the Brain Aging, Injury, and Modulation Lab team.

Our goal is to track the signaling dynamics of individual effectors and toxins in living cells, using a combination of fluorescent genetic reporters, microinjection of labeled bacterial proteins, and live cell imaging techniques. 

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The Terada Lab is focused on several areas of cellular signaling which control basic mechanical and cell fate decision programs. 

The Harbour Lab uses genomic technologies and genetically engineered human cells and mouse models to develop biomarkers and elucidate mechanisms of tumor evolution and metastasis in uveal melanoma and retinoblastoma.

Skip to main content Meet the Principal Investigator Elan Louis, M.D. Elan Louis, M.D. , is Professor and Chair of the Department of Neurology at UT Southwestern Medical Center and holds the endowed title Linda and Mitch Hart Distinguished Chair in Neurology. He specializes in disorders of involuntar…

The central goal of Dr. Asch's research is to uncover the mechanistic underpinnings of how stress and trauma affect brain function, with a particular emphasis on how these experiences shape mental health outcomes with the aim to contribute to the development of novel interventions designed to mitigate the harmful effects of stress and trauma, foster resilience, and ultimately improve overall health and well-being.