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The Sorrell Laboratory utilizes integrative approaches that include metabolomics, transcriptomics, organoid cultures, live microcopy, and animal models, to investigate fundamental pathways that control the uptake of nutrients and the biosynthesis of macromolecules in proliferative cells.

Our lab has investigated the strengths and limitations of current biomarkers for risk prediction and cardiovascular screening.

Our lab has ongoing research within cardiovascular disease registries and administrative claims databases such as the AHA-Get With The Guidelines-Heart Failure program and CMS Medicare data, to study the impact of care provided during in-hospital and outpatient clinical encounters on long-term outcomes among patients with cardiovascular diseases such as heart failure.

Our lab has many ongoing HFpEF clinical trials, ranging from single-center, investigator-initiated research to large scale, multicenter trials. We investigate strategies to improve outcomes for patients with HFpEF, including novel pharmacotherapeutics, medical devices, and exercise rehabilitation.

Skip to main content Research Cristae Organization Positioning of mitochondrial cristae and functions of the MICOS complex Cristae membranes are the hallmark feature of mitochondria, giving them their distinctive appearance in electron microscopy images. Cristae are home to the respiratory complexes …

The Douglas lab seeks to understand how stress response pathways alter cell physiology, and ultimately influence the aging process and human disease.

Skip to main content Research_Immunotherapy Immunotherapy: Boosting the Immune System to Fight Cancer Our cancer immunotherapy focuses on utilizing both the innate and the adaptive immune system branches for better cancer therapy: (1) In our innate immune system approach, we focus on macrophages, whi…

The Wang Lab uses chemical biology tools to study the molecular mechanisms underlying interesting bacterial behaviors.

Skip to main content Meet Dr. Azab Current Lab Members Lab Alumni Education 2007-2012 | Harvard Medical School/ Dana-Farber Cancer Institute, Boston, MA Title: Post Doctoral Fellow Specialty: Cancer Cell Biology and Immunology (Prof. Irene Ghobrial Lab) 2003-2007 | The Hebrew University of Jerusalem,…

Skip to main content Research Overview Molecular Mechanistic Investigation of Mosaic Chromosomal Disorders Pallister-Killian syndrome is a mosaic chromosomal disorder due to isochromosome 12p. Mosaicism is defined as the presence of two or more genotypes in an individual originated from a single fert…