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Our research is focused on mechanisms underlying acute kidney injury and sepsis.  Our laboratory has implicated mitochondrial maintenance via PGC1alpha and NAD+ as a novel pathway for resilience against acute physiological stressors.

The Sun Lab is focused on developing novel imaging probes for noninvasive assessment of specific biomarkers implicated in disease initiation, progression, or regression, and exploring the translational roles of imaging probes and/or methodologies in clinical medicine practice with the ultimate goal to improve the outcome of patient care.

Our lab focuses on membrane proteins in cholesterol biogenesis, transport, and signaling using multiple approaches from protein engineering, to x-ray crystallography and cryo-EM.

Our current research is focused on biochemical and structural studies of how membrane molecules signal to the actin cytoskeleton through a large, five-protein complex named the WAVE Regulatory Complex (WRC). 

Lab news including events, conferences, publications, and accomplishments of the CMRU.

Skip to main content Flux Technology Measuring the rate of lipid biosynthesis has traditionally been done using radio-isotope labeling. While this technology is very sensitive, it is inherently dangerous due to the radioactivity and fairly non specific. Stable-isotope labeling provides an alternative…

The McAdams Lab at UT Southwestern uses neuroimaging and behavioral measures to investigate the connections between social, psychological, and biological aspects of eating disorders.

Active and Inactive Grants for the Cardiometabolic Research Unit

Skip to main content Research_NanoTherapy Nanoparticle for the Treatment of Cancer Our research focuses on customizing the size, payload, and targeting moiety of our engineered nano-particles aiming to develop innovative therapeutic strategies that can specifically and efficiently deliver the desired…

Skip to main content Research_Cancer Biology Mechanisms of Drug Resistance and Metastasis & Their Therapeutic Applications Drug resistance and metastasis are the most challenging aspects of cancer treatment. The dynamic interaction between the tumor cells and their tumor microenvironment (TME) plays …