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Ready; Catalysis Isomerization/cyclization-1 R M R' M R R' H R R' M H MH R R' H R' M M H Olefin insertion into Metal alkyl can be followed by hydride elimination or additional olefin insertions: -dimerization/oligomerization -small molecules -polymerization Recall: elec…

Oxidation of Unsaturated Systems 2 general reactivity patterns: X H X Yn+2 X+ Yn ++ OH simple example O A- Me2SCl+ S+ O + S + Cl- 2 electron oxidation 1 electron oxidation Xor -1 e- or X we will focus on oxidation of aromatic rings and enol/enolate systems Couple Eo Fe(III) + e- Fe(II…

Oxidations at Carbon General references March, Advanced Org Chem, 1992, 1158-1238 Trost, Comp. Org. Syn. 1991, vol 7 Carey and Sundberg, Advanced Org Chem, part B, 615-664 Smith, Org Syn, Chap 3 H CH3 C(-IV) R CH3 C(-III) R CH2 OH C(-1) R CH OH RR H2 C R C(-II) R C O R C(0) R CH O …

1 P(tBu)2 P(tBu)2 CuBr P Pd P P P PBu3 Pt H Et3P Cl PEt3 Ir S R3P H PR3 H S -S PF6 - Ir S R3P H PR3 H P P Pd PF6 - Pt H Et3P Cl PEt3 Py P P Ir S R3P H PR3 H PF6 - Pt H Et3P Py PEt3 Cl Fe Pt H Et3P Py PEt3 P P Cl- Organometallic Reaction Mechanisms Ligan…

Protecting Groups in Organic Synthesis-1 Ready Protecting groups are a sad fact of synthetic chemistry They are usually needed, but rarely desired Many syntheses have stalled because of trouble putting on or removing protecting groups 4 bas…

Epoxidation, Dihydroxylation, and the Utility of Epoxides and Diols Ready Outline: Epoxidation Condensation approaches Darzens condensation Sulfur ylides With organic peroxides Peroxy acids Peroxy iminic acids Dioxiranes DMDO Enantioselective versions Metal-catalyzed Approaches V(O)(acac)2 Sha…

Handbook for Postdoctoral Scholars at UT Southwestern Postdoctoral Affairs Office UT Southwestern Medical Center 5323 Harry Hines Blvd. Dallas, TX 75390-9004 SGSPostdocOffice@UTSouthwestern.edu www.utsouthwestern.edu/Postdocs mailto:SGSPostdocOffice@UTSouthwestern.edu http:/…

User manual for TYGRESS Tomography-Guided 3D Reconstruction of Subcellular Structures (TYGRESS) is a hybrid method, which combines the advantageous features of both single particle cryo-EM and cryo-ET/subtomogram averaging to provide high-resolution structures of macromolecular complexes wi…

CURRICULUM VITAE Jef Karel De Brabander, Ph.D. Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX-75390-9038 Voice: (214) 648-7808, Fax: (214) 648-0320, E-mail: jef.debrabander@utsouthwestern.edu Education December…

Ying et al., Sci. Transl. Med. 17, eadq1975 (2025) 26 February 2025 S c i e n c e T r a n s l at i o n a l M e d i c i n e | R e s e a r c h A r t i c l e 1 of 11 M E D I C A L D E V I C E S An electroadhesive hydrogel interface prolongs porcine gastrointestinal mucosal theranostics Bi…