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Intratumoral Delivery of B-Lapachone via Polymer Implants for Prostate Cancer Therapy Ying Dong,1Shook-Fong Chin,1Elvin Blanco,1Erik A. Bey,1Wareef Kabbani,2 Xian-Jin Xie,1,3 William G. Bornmann,4 David A. Boothman,1andJinming Gao1 Abstract Purpose: h-Lapachone (ARQ 501, a formulation of h-lapachon…

  In vivo Off-Resonance Saturation Magnetic Resonance Imaging of AvB3-Targeted Superparamagnetic Nanoparticles Chalermchai Khemtong, 1 Chase W. Kessinger, 1 Jimin Ren, 2 Erik A. Bey, 1 Su-Geun Yang, 1 Jagadeesh Setti Guthi, 1 David A. Boothman, 1 A. Dean Sherry, 2 and Jinming Gao 1 1Dep…

Zinc ferrite nanoparticles as MRI contrast agentsw Carlos Bárcena, a Amandeep K. Sra, a Girija S. Chaubey, b Chalermchai Khemtong, a J. Ping Liu b and Jinming Gao* a Received (in Cambridge, UK) 21st January 2008, Accepted 15th February 2008 First published as an Advance Article on the web 11…

Cooperativity Principles in Self-Assembled Nanomedicine Yang Li,† Yiguang Wang,†,‡ Gang Huang,† and Jinming Gao*,† †Department of Pharmacology, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, United States ‡Beijing Key Laboratory …

1 Ready; Catalysis Organometallics: Definitions Organometallics: Hard to define usefully and completely at the same time, but generally: Compounds containing metal-carbon bond(s). Fe Cl Ti Cl Cl ClFe NC NC CN CN CN CN K3 No question: Organometallic No question: Inor…

Ready; Catalysis Intro Helpful Texts: Principles and Applications of Organotransition Metal Chemistry, Collman, Hegedus, Norton, Fink The Organometallic Chemistry of the Transition Metals, Crabtree; Prof. M-Christina White’s lecture notes: http://www.courses.fas.harvard.edu/~chem153/ (many …

1 Ready; Catalysis Hydrogenation Categories and Dichotomies: Heterogeneous or Homogeneous Neutral or Cationic Directed or Non-directed Heterolytic or Homolytic H2 Activation Racemic or Enantioselective Syn or Trans Addition Homogeneous Hydrogenation Rh Ph3P Ph3P Cl …

Ready; Catalysis Nonlinear Effects Outline Definitions Origins of nonlinear effects in enantioselective reactions ML2 model Reservoir model Transition-state model Kinetic aspects of nonlinear effects Asymmetric amplification Cool tricks Origin of biotic asymmetry? K…

Ready; Catalysis Isomerization/cyclization-1 R M R' M R R' H R R' M H MH R R' H R' M M H Olefin insertion into Metal alkyl can be followed by hydride elimination or additional olefin insertions: -dimerization/oligomerization -small molecules -polymerization Recall: elec…

1 Ready; Catalysis Kinetics-1 There are only two important things in chemistry, kinetics and thermodynamics. And, exp(-ΔG/RT) = k1/k-1, so there’s really only one thing. Kinetics provides information about the transition state of a reaction. We’ll use a simple example to lear…