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Ready; Catalysis Conjugate Addition Topics covered 1. 1,4 addition involving copper a. stoichiometric reactions b. catalytic reactions c. allylic substitution 2. Conjugate addition without copper a. Ni-based systems b. Rh-based systems 3. Catalytic addition of heteroat…

Showcasing research from the Microfl uidics and BioMEMS Laboratory of Professor Xinyu Liu, Department of Mechanical and Industrial Engineering, University of Toronto, Canada. NanoPADs and nanoFACEs: an optically transparent nanopaper-based device for biomedical applications Nanopaper-based anal…

Reagent/Reaction Use Ref Note DMSO/DCC (Pfitzner- Moffatt or Moffatt) Alcohol ketone/aldehyde Jacs 1963, 3027; Mech: JACS, 1965, 5561, JOC, 1967, 1926 First DMSO-based; DCC pain to remove; EDCI better DMSO/Ac2O “ Jacs 1967, 2416 DMSO/TFAA “ Jacs, 1975, 2758 DMSO/SO3-Pyridine (Parikh- D…

Oxidation of Unsaturated Systems 2 general reactivity patterns: X H X Yn+2 X+ Yn ++ OH simple example O A- Me2SCl+ S+ O + S + Cl- 2 electron oxidation 1 electron oxidation Xor -1 e- or X we will focus on oxidation of aromatic rings and enol/enolate systems Couple Eo Fe(III) + e- Fe(II…

Oxidations at Carbon General references March, Advanced Org Chem, 1992, 1158-1238 Trost, Comp. Org. Syn. 1991, vol 7 Carey and Sundberg, Advanced Org Chem, part B, 615-664 Smith, Org Syn, Chap 3 H CH3 C(-IV) R CH3 C(-III) R CH2 OH C(-1) R CH OH RR H2 C R C(-II) R C O R C(0) R CH O …

1 R Co(CO)3(OC)3Co O O Δ (OC)3Co O R H O R H2 R H O (OC)4Co R (OC)4Co Co(CO)4 H H (CO)4CoH H2 CO R O H R CO (OC)3Co R (OC)3Co H R H2 R (OC)3Co R The Oxo process -developed in 1938 by Otto Roelen -Principle method for hydroformylation of terminal alkenes industrially …

Handbook for Postdoctoral Scholars at UT Southwestern Postdoctoral Affairs Office UT Southwestern Medical Center 5323 Harry Hines Blvd. Dallas, TX 75390-9004 SGSPostdocOffice@UTSouthwestern.edu www.utsouthwestern.edu/Postdocs mailto:SGSPostdocOffice@UTSouthwestern.edu http:/…

Epoxidation, Dihydroxylation, and the Utility of Epoxides and Diols Ready Outline: Epoxidation Condensation approaches Darzens condensation Sulfur ylides With organic peroxides Peroxy acids Peroxy iminic acids Dioxiranes DMDO Enantioselective versions Metal-catalyzed Approaches V(O)(acac)2 Sha…

1 P(tBu)2 P(tBu)2 CuBr P Pd P P P PBu3 Pt H Et3P Cl PEt3 Ir S R3P H PR3 H S -S PF6 - Ir S R3P H PR3 H P P Pd PF6 - Pt H Et3P Cl PEt3 Py P P Ir S R3P H PR3 H PF6 - Pt H Et3P Py PEt3 Cl Fe Pt H Et3P Py PEt3 P P Cl- Organometallic Reaction Mechanisms Ligan…

1 Ready; Catalysis Kinetics-1 There are only two important things in chemistry, kinetics and thermodynamics. And, exp(-ΔG/RT) = k1/k-1, so there’s really only one thing. Kinetics provides information about the transition state of a reaction. We’ll use a simple example to lear…