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Formation of Protein Charge Ladders by Acylation of Amino Groups on Proteins Ian J. Colton, Janelle R. Anderson, Jinming Gao, Robert G. Chapman, Lyle Isaacs, and George M. Whitesides* Contribution from the Department of Chemistry and Chemical Biology, HarVard UniVersity, 12 Oxford Street, Cambridge…

1310 IEEE TRANSACTIONS ON MEDICAL IMAGING, VOL. 21, NO. 10, OCTOBER 2002 X-Ray Computed Tomography Methods forIn Vivo Evaluation of Local Drug Release Systems Kyle A. Salem, Student Member, IEEE, Agata Szymanski-Exner, Roee S. Lazebnik, Michael S. Breen, Jinming Gao, and David L. Wilson�, Member, I…

Postdoctoral Training in Gene Regulation Molecular Mechanisms, Genomics, Mouse Models, Translational/Clinical A postdoctoral training position is available in the laboratory of Dr. Cristel Camacho, in the Cecil H. and Ida Green Center for Reproductive Biology Sciences at UT Southwestern Medical…

Proc. Natd. Acad. Sci. USA Vol. 91, pp. 12027-12030, December 1994 Chemistry Determination of the effective charge of a protein in solution by capillary electrophoresis (protein charge ladders) JINMING GAO, FRANK A. GOMEZ, RALPH HARTER, AND GEORGE M. WHITESIDES Department of Chemistry, Harvard Uni…

Subscriber access provided by UNIV TEXAS SW MEDICAL CENTER Accounts of Chemical Research is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Affinity Capillary Electrophoresis Yen-Ho Chu, Luis Z. Avila, Jinming Gao, and George M. Whitesides Acc. Chem. Re…

2292 J . Med. Chem. 1996,38, 2292-2301 Increasing Binding Constants of Ligands to Carbonic Anhydrase by Using “Greasy Tails” Jinming Gao, Shuang Qiao, and George M. Whitesides* Department of Chemistry, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138 Received February 13,…

Eugene McDermott Center for Human Growth and Development Southwestern Medical School 5323 Harry Hines Blvd. / Dallas, Texas 75390-8591 (214) 648-1695 Fax (214) 648-1666 Email: chao.xing@utsouthwestern.edu Computational Biologist I & II The Bioinformatics Lab of McDermott Center for Human G…

Eugene McDermott Center for Human Growth and Development Southwestern Medical School 5323 Harry Hines Blvd. / Dallas, Texas 75390-8591 (214) 648-1695 Fax (214) 648-1666 Email: chao.xing@utsouthwestern.edu Postdoctoral Fellowship in Statistical Genomics & Genetics The Bioinformatics L…

Substrate pKa's. Numbers are approximations for outside the range -2 - 16, but useful to know. For an extensive list, see http://www.chem.wisc.edu/areas/reich/pkatable/ Inorganics H2O DMSO CF3SO3H -14 HCl -8 H3O+ -2 H2O 16 NH4Cl 9 Organic X-H AcOH 5 12 O+ CH3Ph H -6 Me2OH+ -4 CH3SO3H -3 …

Reactivity Umpolung-1 Ready Reactivity Umpolung: reversal of normal polarity electrophiles become nucleophiles nucleophiles become electrophiles Outline: 1. electrophilic heteroatoms 2. acyl anions 3. homoenolates 4. the cyclopropane tric…