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β‑Lapachone and Paclitaxel Combination Micelles with Improved Drug Encapsulation and Therapeutic Synergy as Novel Nanotherapeutics for NQO1-Targeted Cancer Therapy Ling Zhang,† Zhen Chen,† Kuan Yang,† Chun Liu,† Jinming Gao,‡ and Feng Qian*,† †Department of Pharmacology and Pharmaceutical Sciences a…

Imaging Agents DOI: 10.1002/anie.201301135 Multi-Chromatic pH-Activatable 19F-MRI Nanoprobes with Binary ON/OFF pH Transitions and Chemical-Shift Barcodes** Xiaonan Huang, Gang Huang, Shanrong Zhang, Koji Sagiyama, Osamu Togao, Xinpeng Ma, Yiguang Wang, Yang Li, Todd C. Soesbe, Baran D. Sumer, Masay…

Theranostics 2013, Vol. 3, Issue 2 http://www.thno.org 116 TThheerraannoossttiiccss 2013; 3(2):116-126. doi: 10.7150/thno.5411 Research Paper Superparamagnetic Iron Oxide Nanoparticles: Ampli- fying ROS Stress to Improve Anticancer Drug Efficacy Gang Huang1*, Huabing Chen1*, Ying Do…

Bioorganic Chemistry cRGD-Functionalized Polymer Micelles for Targeted Doxorubicin Delivery** Norased Nasongkla, Xintao Shuai, Hua Ai, Brent D. Weinberg, John Pink, David A. Boothman, and Jinming Gao* Low water solubility, rapid phagocytic and renal clearance, and systemic toxicity represent three…

Noninvasive Monitoring of Local Drug Release Using X-ray Computed Tomography: Optimization and In Vitro/In Vivo Validation AGATA SZYMANSKI-EXNER,1 NICHOLAS T. STOWE,2 KYLE SALEM,1 ROEE LAZEBNIK,1 JOHN R. HAAGA,3 DAVID L. WILSON,1 JINMING GAO1,3 1Department of Biomedical Engineering, Case Western R…

Journal of Controlled Release 91 (2003) 157–166 www.elsevier.com/ locate/ jconrel Q uantification of in vivo doxorubicin transport from PLGA millirods in thermoablated rat livers a ,1 b a a a ,*Feng Qian , Nicholas Stowe , Erin H. Liu , Gerald M. Saidel , Jinming Gao aDepartment of Biomedical Engin…

Journal of Controlled Release 151 (2011) 271–277 Contents lists available at ScienceDirect Journal of Controlled Release j ourna l homepage: www.e lsev ie r.com/ locate / jconre l N A N O M E D IC IN E Nanoscopic micelle delivery improves the photophysical properties and efficacy of photodynami…

1310 IEEE TRANSACTIONS ON MEDICAL IMAGING, VOL. 21, NO. 10, OCTOBER 2002 X-Ray Computed Tomography Methods forIn Vivo Evaluation of Local Drug Release Systems Kyle A. Salem, Student Member, IEEE, Agata Szymanski-Exner, Roee S. Lazebnik, Michael S. Breen, Jinming Gao, and David L. Wilson�, Member, I…

Polymer Implants for Intratumoral Drug Delivery and Cancer Therapy BRENT D. WEINBERG,1 ELVIN BLANCO,2 JINMING GAO2 1Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106 2Simmons Comprehensive Cancer Center, University of Texas Southwestern M…

Fabrication and characterization of controlled release poly(D,L-lactide-co-glycolide) millirods Feng Qian, Agata Szymanski, Jinming Gao Cancer-Targeted Drug Delivery Laboratory, Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 Receive…