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ARTICLE Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery F. J. Voskuil 1,13, P. J. Steinkamp 2,13, T. Zhao3, B. van der Vegt 4, M. Koller2, J. J. Doff4, Y. Jayalakshmi3, J. P. Hartung5, J. Gao 6,7, B. D. Sumer 6✉, M. J. H…

ARTICLE Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan Chensu Wang1,2, Hanspeter Niederstrasser3, Peter M. Douglas4, Rueyling Lin4, Juan Jaramillo4, Yang Li1, Nathaniel W. Olswald3, Anwu Zhou3, Elizabeth A. McMillan2, Saurabh Mendiratt…

Theranostics 2020, Vol. 10, Issue 7 http://www.thno.org 3340 Theranostics 2020; 10(7): 3340-3350. doi: 10.7150/thno.41239 Research Paper Detection of Lymph Node Metastases by Ultra-pH-Sensitive Polymeric Nanoparticles Zachary T. Bennett1, Qiang Feng1, Justin A. Bishop2, Gang Huang1, …

Contents lists available at ScienceDirect Journal of Controlled Release journal homepage: www.elsevier.com/locate/jconrel Synergistic STING activation by PC7A nanovaccine and ionizing radiation improves cancer immunotherapy Min Luoa,b,1, Zhida Liua,c,1, Xinyi Zhanga, Chuanhui Hanc, Layla Z. Saman…

Targeting the Oncogene KRAS Mutant Pancreatic Cancer by Synergistic Blocking of Lysosomal Acidification and Rapid Drug Release Chao Kong,† Yang Li,‡ Zhengsheng Liu,† Junxiao Ye,† Zhaohui Wang,‡ Ling Zhang,† Weijian Kong,† Huiqin Liu,† Chun Liu,† Huanhuan Pang,§ Zeping Hu,§ Jinming Gao,*,‡ and Feng Q…

Cooperativity Principles in Self-Assembled Nanomedicine Yang Li,† Yiguang Wang,†,‡ Gang Huang,† and Jinming Gao*,† †Department of Pharmacology, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, United States ‡Beijing Key Laboratory …

Transistor-like Ultra-pH-Sensitive Polymeric Nanoparticles Published as part of the Accounts of Chemical Research special issue “Nanomedicine and Beyond”. Qiang Feng, Jonathan Wilhelm, and Jinming Gao* Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 6…