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Anatomic Pathology - Services - Histo Pathology Core - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/histo-pathology/services/anatomic-pathology.html
Anatomic Pathology The Histo Pathology Core offers anatomic pathology services on an as needed basis to train clients as well as facilitate morphologic and histologic endpoints in large terminal studies with mice. The Core provides expert training in the following procedures with mice: Transcardial W…
mRNA-Seq - Next Generation Sequencing Core - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/next-generation-sequencing/ngs-applications/mrna-seq.html
mRNA-Seq Samples are run on the Agilent Tapestation 4200 to determine level of degradation thus ensuring only high quality RNA is used (RIN Score 8 or higher). The Qubit fluorimeter is used to determine the concentration prior to staring library prep. One microgram of total DNAse treated RNA is then …
Aqueous Solubility Determination: Preclinical Pharmacology Core Lab - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/preclinical-pharmacology/pricing-and-services/aqueous-solubility-determination.html
Aqueous Solubility Determination Poor aqueous solubility can limit the ability to develop lead compounds as in vivo probes and therapeutics. Aqueous solubility affects absorption, formulation and ability of a compound to be delivered in sufficient concentrations to be active, and even in vitro activi…
Plasma Protein Binding: Preclinical Pharmacology Lab - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/preclinical-pharmacology/pricing-and-services/plasma-protein-binding.html
Plasma Protein Binding Plasma protein binding (PPB) plays an important role in the pharmacokinetics (PK) and pharmacodynamics (PD) of a drug. Free drug levels are closely related to the pharmacological effects of a compound as the principal determinant of tissue distribution, cell entry, receptor int…
Metabolite Profiling: Preclinical Pharmacology Lab - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/preclinical-pharmacology/pricing-and-services/metabolite-profiling.html
Metabolite Profiling If a particular chemical series shows poor metabolic stability, knowledge of the specific metabolites formed can aid chemists in the design of more stable analogues. A comparison of the metabolites formed in different species can also aid in the selection of appropriate species f…
General Usage: Electron Microscopy Core Facility - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/emcf/policies/general-usage.html
The Electron Microscopy Core Facility (EMCF) offers TEM of cells & tissues, negative staining, whole-mount SEM, correlative LM and EM, and Immunogold labeling.
Whole Transcriptome - Next Generation Sequencing Core - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/next-generation-sequencing/ngs-applications/whole-transcriptome.html
Whole Transcriptome Samples are run on the Agilent Tapestation 4200 to determine level of degradation thus ensuring only high quality RNA is used (RIN Score 8 or higher). The Qubit fluorometer is used to determine the concentration prior to staring library prep. One microgram of total DNAse treated R…
Zeiss LSM 780 Inverted: Quantitative Light Microscopy Core Facility - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/quantitative-light-microscopy/equipment-fees-and-services/zeiss-lsm-780-inverted.html
Zeiss LSM 780 Inverted (NL5.120N) Visible laser lines: 405, 458, 488, 514, 561, 594, and 633 nm for conventional confocal applications. Spectral detection for optimized CFP/YFP FRET and spectral unmixing of closely overlapping fluorophores (e.g. GFP and YFP, multiplexed Qdots). Tunable NIR laser for …
Nikon CSU-W1 SoRa: Quantitative Light Microscopy Core Facility - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/quantitative-light-microscopy/equipment-fees-and-services/nikon-csu-w1-sora.html
Nikon CSU-W1 SoRa (NL5.120R) Spinning disk confocal microscope for fixed or live samples Build for speed, allowing visualization of rapid dynamics in live cells and tissues SoRa module for resolution down to 120 nm. Piezo z-drive for fast z-stack acquisition. Fast xy-stage for multi-point acquisition…
Sample Submission: Electron Microscopy Core Facility - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/emcf/policies/sample-submission.html
The Electron Microscopy Core Facility (EMCF) offers TEM of cells & tissues, negative staining, whole-mount SEM, correlative LM and EM, and Immunogold labeling.