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Skip to main content Meet the Team Meet the Principal Investigator Ivan D'Orso, Ph.D. The D’Orso lab has extensive experience in studying mechanisms of gene regulation in the context of human health and disease. Two major areas of study have been: 1) the characterization of mechanisms regulating HIV-…

Skip to main content Contact Us Tao Yue, Ph.D. Assistant Professor Center for Genetics of Host Defense Kidney Cancer Program Department of Immunology Simmons Comprehensive Cancer Center UT Southwestern Medical Center Office: NB9.104B; Lab: NB9.106 Phone Number: (214)-648-6636 Email address: Email Get…

Skip to main content Lab Approach Our research program aims to elucidate the basic principles that govern gene regulatory programs in normal and disease states. Specifically, we are exploring new mechanisms of transcriptional elongation control, factor-chromatin interaction, non-coding RNA functions,…

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Skip to main content Research Hybrid Structural Analysis We use a variety of analytical approaches to uncover the complex structure-function relationship among intrinsically disordered proteins . One of our major tools is cross-linking mass spectroscopy (XL-MS), which defines contact points within a …

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Skip to main content Research Tau Aggregation Tau protein, which normally functions to stabilize the physical framework of cells, sometimes take on a shape that creates tangles in human brains that are linked to neurodegenerative diseases called tauopathies. We want to understand how the inert form t…