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The Ishii Laboratory is interested in understanding the bidirectional relationship between brain function and systemic metabolism with an emphasis on metabolic deficits in Alzheimer’s disease and how it differs from normal aging. Our laboratory focuses on generating hypotheses derived from open questions in clinical neurology and neuroendocrinology, testing these hypotheses using molecular genetics and neuroscience techniques in the laboratory, and whenever possible verifying these findings in clinically relevant human research studies. 

Skip to main content Lab Fun Laser tag (victorious vs the Nam lab!) Out in nature on a hike First group picture! Spring 2023 We moved down the hall! Don't look directly at the sun! Summer 2024 Taking at break from science to check out the birds (retreat 2024) Lab in summer 2023 Halloween 2024 Join Ou…

Skip to main content Neural-crest Stem Cells and Malignant Peripheral Nerve Sheath Tumor (MPNST) MPNST, a sarcoma arising from the neural-crest stem cell lineage in the peripheral nerve, is the leading cause of death for individuals with NF1. The presence of benign and premalignant lesions, namely, p…

Skip to main content News April 2026 Lunch at the Faculty Club Our group had lunch together at the Faculty Club and enjoyed a warm, thoughtful conversation about career development, research, and life at UTSW. During lunch, Dr. Zaman shared advice with Micah, a third-year undergraduate student who is…

Skip to main content Research Alzheimer's disease is the most common cause of dementia in the elderly and remains a devastating disease with currently no cure and limited therapeutic options. The exact pathogenesis of Alzheimer’s disease is being actively investigated, but a leading hypothesis is tha…

Skip to main content Join the Team Mentoring the next generation of clinicians, scientists, and students is an essential part of our research program. We are always interested in having dedicated scientists join our research laboratory, particularly students. Please send your CV for consideration | E…

Skip to main content NF1-associated Autism (NF1-Autism) – Non-cancer Manifestations with TGS Syndromes Approximately 40%-70% of children with NF1 exhibit one or more forms of specific learning disabilities and 20%-45% have the features of autistic spectrum disorder (ASD). Thus, NF1 represents a uniqu…

Skip to main content Meet the Team Makoto Ishii, M.D., Ph.D. Principal Investigator & Assistant Professor Dr. Makoto Ishii is a board-certified neurologist and a physician-scientist dedicated to both patient care and biomedical research focusing primarily on Alzheimer’s disease and related neurodegen…

Our research focuses on developing and testing novel immunotherapies for meningiomas (the most common brain tumors in adults) as well as on understanding the tumor immune microenvironment of meningiomas and other skull base tumors.

This people page introduces the principal investigator, Dr. Shuang Liang, of the Liang Lab along with current and past members of the lab.