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We anticipate providing mechanistic understanding of clinical trial observations through the examination of patient biospecimens and in vivo modeling in mice. 

We anticipate this work to enhance functional recovery and improve the quality of life for trauma patients, while advancing our understanding of HO pathogenesis and normal tissue response to radiation.

Skip to main content Contact Us Email: Matthew Sun ( Email ) Lab Phone: 214-648-4378 Lab Address: UT Southwestern Medical Center Pickens Biomedical Building 6001 Forest Park Rd. ND3.300 Dallas, TX 75390 To become a member of our lab, please email Matthew Sun, M.D. ( email )

Skip to main content Research Research Focus We seek to understand the tumor immune microenvironment and aim to develop novel immunotherapy for meningiomas. Positioned at the crossroads of neuroscience, neuroimmunology, and neuro-oncology, our work bridges fundamental cancer discovery with translatio…

Our laboratory is interested in understanding how the ubiquitin-mediated protein degradation regulates gene expression and how failure of these pathways contributes to developmental disorders and diseases, such as neurodegeneration and cancer.

Learn about the Sharma Lab's research.

Our research focuses on developing and testing novel immunotherapies for meningiomas (the most common brain tumors in adults) as well as on understanding the tumor immune microenvironment of meningiomas and other skull base tumors.

Skip to main content Publications Structural basis for substrate selectivity by site-one protease revealed by studies with a small molecule inhibitor . Bullington AV , Micallo I, Bajaj B , Kumar P , Schlamowitz N , Silva A , Hendrix S, Zelcer N*, and Kober DL * . PNAS (2025). *Co-corresponding author…

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The Louros Lab uses a hybrid approach combining molecular biophysics, structural biology, and bioinformatics to investigate protein stability, misfolding, and aggregation, with a particular interest in neurodegenerative diseases.