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Researchers at UT Southwestern Medical Center have discovered that a diet free of the amino acid tryptophan can effectively halt the growth of liver cancer in mice. Their findings, published in Nature Communications, offer new insights for dietary-based cancer treatments and highlight the critical role of the tryptophan metabolite indole 3-pyruvate in liver tumor development.

Cancer cells appear to hijack a genetic pathway involved in DNA repair to drive malignancy and overcome treatment, a study led by UT Southwestern Medical Center researchers shows. Their findings, published in Cell, explain how chromosomes in some tumors undergo massive rearrangements and could lead to new strategies to avoid cancer drug resistance.

A study of mutant models of fragile X syndrome (FXS), a genetic disorder related to autism and intellectual disability, shows that activation of the cerebellum mitigates aberrant responses in sensory processing areas of the brain and improves neurodevelopmental behaviors.

Researchers at UT Southwestern Medical Center developed nanoparticles that successfully edited the disease-causing gene in the lungs of a mouse model of cystic fibrosis (CF), swapping a mutated form for a healthy one that persisted in stem cells. Their findings, reported in Science, could offer hope for people with CF and other debilitating genetic lung diseases.

Patients with fibromyalgia and irritable bowel syndrome (IBS) who take multiple medications are more likely to develop severe drug intolerance than healthy patients, UT Southwestern Medical Center researchers reported.

An extensive family of proteins that gives human skin mechanical strength also appears to organize molecular signals that control skin cell activity, a study led by UT Southwestern Medical Center researchers shows. Their findings, published in Developmental Cell, could lead to new ways to fight a host of skin diseases, including ulcers and skin cancer.

Exercising at a high level doesn’t affect the progression of calcium buildup in the arteries, even among older athletes such as marathoners who tend to have higher coronary artery calcium (CAC) scores, according to new research from UT Southwestern Medical Center.

Researchers at UT Southwestern Medical Center have developed a novel artificial intelligence (AI) model to improve the detection of breast cancer metastasis, which could reduce the need for needle or surgical biopsies.

Nutritious meal kits and no-prep meals improved food security and perceived dietary quality among clients of a Dallas food pantry, according to a pilot study led by UT Southwestern Medical Center.

Patients with moderate to severe treatment-resistant depression (TRD) might have better symptom relief from ketamine infusions than from electroconvulsive therapy (ECT), but those with severe TRD could benefit more from ECT early in treatment, an analysis led by a UT Southwestern Medical Center researcher shows.