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– The STING protein, known for helping cells fight viral infections by generating inflammation, also appears to function as a quality control sensor for organelles that serve as cellular waste disposal systems, UT Southwestern Medical Center researchers found. Their study, published in Molecular Cell, helps explain critical features of diseases called lysosomal storage disorders and could eventually lead to new treatments for these and other neurodegenerative diseases.

Using a novel method that gives a readout of which proteins are in specific locations within cells, UT Southwestern Medical Center researchers have identified a protein that plays a key role in cell adhesion and movement.

Black and Hispanic children with high-risk neuroblastoma experience worse survival outcomes than their white peers, even when treated in frontline clinical trials, according to a study led by a UT Southwestern Medical Center researcher.

A multidisciplinary team of UT Southwestern Medical Center specialists, led by Nader Pouratian, M.D., Ph.D., and Peter Tsai, M.D., Ph.D., has received a grant worth up to $5 million from the Raynor Cerebellum Project to develop neuromodulation therapies for patients with cerebellar disorders of the brain.

Researchers at UT Southwestern Medical Center have linked blindness in animal models to a brain-wide cellular stress response that’s a common risk factor for dementia. Their findings, published in Nature Communications, could help explain the connection between vision or hearing loss and dementia.

– A “clot-busting” drug recently approved to treat acute ischemic strokes (AIS) that can be delivered quickly works as well as a decades-old medication used by most hospitals in the U.S. and could hold significant advantages for some patients, a study led by a UT Southwestern Medical Center researcher shows. The findings, published in JAMA Network Open, could encourage more hospitals to use the newer drug, tenecteplase.

A well-known class of drugs used to manage Type 2 diabetes and control weight could offer hope for patients who also struggle with related chronic kidney disease (CKD), researchers at UT Southwestern Medical Center found.

An emotional overattachment to social media may be associated with increased severity of mental health symptoms among young people being treated for depression, anxiety, and suicidal thoughts, according to researchers at UT Southwestern Medical Center.

Multidrug resistance in cancer can be overcome by combining a drug that blocks a key enzyme with another anticancer drug, according to a study in preclinical models led by researchers at UT Southwestern Medical Center. The findings, published in Science Advances, could have implications for patients with certain cancers that have KRAS-G12C mutations after resistance to drug therapy develops.

The importance of increasing the number of Black male doctors in the United States will be the subject of a virtual panel discussion at UT Southwestern in advance of the release of a documentary on the issue.