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Skip to main content Research What is Ubiquitin? Ubiquitin is a small eukaryotic protein that is attached to aberrant proteins and promotes their degradation as a form of protein quality control. Ubiquitin is first bound by a ubiquitin activating enzyme (E1) in an ATP-dependent manner and transferred…

We aim to elucidate the role of the innate immune system in damage and repair following ischemic and hemorrhagic insults to the brain. We are specifically focused on innate immune drivers of secondary injury following aneurysmal subarachnoid hemorrhage and the immune response triggered by acute intracranial pressure spikes during aneurysm rupture. We also look into promoting recovery after ischemic stroke by reprogramming microglia and peripheral myeloid cells to drive repair. In addition, we are pursuing the development of therapeutics for intraarterial immunomodulation for chronic subdural hemorrhage.

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Skip to main content Meet the Principal Investigator Dawn Wetzel, M.D., Ph.D. Assistant Professor of Pediatrics and Biochemistry Principal Investigator Dr. Dawn M. Wetzel is a physician-scientist at UT Southwestern Medical Center. She received her M.D., Ph.D. from Washington University in St. Louis s…

Dr. Ambarish Pandy's lecture presentation at various conferences and institutions.

The Goss Research Lab collaborates with other institutions and research groups to share datasets to help predict outcomes for preterm born adults. 

Skip to main content Resources Databases GTEx Portal GPCR database BioPlex Interactome At UTSW UT Southwestern Touchstone Diabetes Center UTSW CMB Graduate Program UTSW 3MD Ph.D Track

Dr. Park’s research focuses on the visual system and how the projection neurons in the retina, the retinal ganglion cell axons, find their targets and form synapses in the brain. He is investigating two key areas: 1) cellular and molecular mechanisms underlying the death of neurons and lack of regeneration in the central nervous system after injury and in degenerative diseases like glaucoma and 2) mechanisms by which neurons form proper connections with each other.

Dr. Song's laboratory focuses on understanding the mechanisms of cell death, including apoptosis, ferroptosis, pH-dependent cell death, and immunogenic cell death.

The Wang lab applies single-molecule fluorescence biophysical, quantitative biochemical, structural, and genetics approaches to unravel the intricate relationships between structure, dynamics and function in complex dynamic biological systems. Our primary goal is to understand the dynamic mechanisms of cytosolic and mitochondrial protein synthesis and how they are dysregulated in human diseases.