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Current Research projects in the Cardiometabolic Research Unit

We study ion channel clusters. To study such clusters without the complications arising from the complex cellular environment, components from cells are purified and studied in isolation.

Skip to main content Post-squalene Cholesterol Biosynthetic Pathways There has been an outstanding debate over the route of cholesterol biosynthesis since it was first discovered in the 1950s. Two alternative pathways have been proposed, the Bloch and Kandutsch-Russell pathways. Using deuterium water…

Deja Lab is dedicated to advancing the field of metabolomics and fluxomics in metabolic disease research.

Our lab has many ongoing HFpEF clinical trials, ranging from single-center, investigator-initiated research to large scale, multicenter trials. We investigate strategies to improve outcomes for patients with HFpEF, including novel pharmacotherapeutics, medical devices, and exercise rehabilitation.

We apply advanced MRI technologies to study many different diseases.

Malter Lab focuses on exploring and characterizing intracellular signaling pathways in the immune and nervous systems and identifying how defects/abnormalities can lead to disease.

Our lab has ongoing research within cardiovascular disease registries and administrative claims databases such as the AHA-Get With The Guidelines-Heart Failure program and CMS Medicare data, to study the impact of care provided during in-hospital and outpatient clinical encounters on long-term outcomes among patients with cardiovascular diseases such as heart failure.

Drapkin Lab investigates the molecular drivers of oncogenesis, metastasis, and chemoresistance in small cell lung cancer (SCLC) to discover new therapeutic targets. 

The HMG CoA reductase regulatory system researched by DeBose-Boyd Lab involves a complex, multivalent feedback mechanism that is mediated by sterol and nonsterol end-products of mevalonate metabolism.