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The HMG CoA reductase regulatory system researched by DeBose-Boyd Lab involves a complex, multivalent feedback mechanism that is mediated by sterol and nonsterol end-products of mevalonate metabolism.

Xin Li xin.li@utsouthwestern.eduUniversity of Texas Southwestern Medical Center5323 Harry Hines Blvd. K04.250Dallas, TX  75390-9063

Our lab are studying host-microbe interactions and tissue immunity using multiple model organisms i) Identifying novel host factors involved in bacterial and fungal sensing to regulate inflammatory diseases. ii) Identifying new microbial factors involved in bacterial and fungal sensing to regulate inflammatory diseases. These factors may include pore-forming toxins and other toxins. iii) Identifying how microbe sensing of host-derived factors in the gut controls microbial commensalism and pathogenicity. iv) Utilizing fungi as a model system, genetic engineering of microbial effectors to understand how a microbe dictates protective immunity, and pathogenic immunity at tissue barriers.

Through our expertise, our expert team is leading the charge to develop more effective alternate therapies for urinary tract infections.

Skip to main content Lab Members Current Lab Members Jongwook Park, Ph.D. Postdoctoral Research Fellow Dr. Jongwook Park received his Ph.D. from Korea University, where he studied the mechanisms of antibiotic resistance in pathogens and microbiota-mediated maternal effects. He joined the Obata Lab in…

The Zhong Lab investigates the fundamental mechanisms of inflammation across metabolic disorders, cancer, and neurodegenerative diseases, with the goal of identifying actionable pathways and developing targeted therapeutic strategies.

The Davenport Lab focuses on quantitative methods for human brain imaging, primarily using MRI and Magnetoencephalography (MEG).

The Ding lab is led by Dr. Kan Ding, an Associate Professor and practicing neurologist who specializes in epilepsy. The lab concentrates on neurocritical care and post-traumatic epilepsy, with the goal of advancing strategies for diagnosis, treatment, and rehabilitation to improve care for those with epilepsy. 

We use in vivo models of ischemic acute kidney injury in mice, and in vitro model systems to perform detailed studies of proinflammatory genes activated by renal ischemia/reperfusion.

Meet Principal Investigator Dr. Lawson Copley.