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Publications from the Farrar Lab

Biosketch for Dr. David Farrar in Farrar Lab

We study how the membrane lipid phosphatidylinositol 4,5 bisphosphate (PIP2) regulates the actin scaffold in proliferating and autophagic cells.

Skip to main content People We believe that to do great science, all have to be welcome to the table. Each voice and each skill push us forward—together. Current Lab Members Josephine Thinwa, M.D., Ph.D. Principal Investigator Zhongju Zou, M.S. Senior Research Scientist Jason Lucavs Ph.D. Student Gio…

The Cobb lab studies signal transduction mechanisms of protein kinases and how kinase structures lead to cell biological functions. We are particularly focused on the contributions of ERK MAP kinases to pancreatic beta-cell function and to lung cancers, and on the cell biological actions of WNK protein kinases.

The discovery of ANP many years ago sparked interest in the use of natriuretic peptides to diagnose and treat heart failure and other salt-retaining disorders. Since then, there have been successes and failures. A more comprehensive understanding of the natriuretic peptide system, including the role of noncardiac factors such as race/ethnicity, may encourage more targeted approaches. One of the original insights of de Bold et al, was that the heart is an endocrine organ. Endocrine therapies are administered to individuals with specific evidence of endocrine dysfunction, not to capture short-term beneficial effects. For instance, thyroid hormone is given only to patients in whom hypothyroidism is demonstrated, not based on its metabolic actions. Studies are warranted to determine whether a similar strategy for the heart’s endocrine system can advance the prevention and treatment of cardiometabolic disease. CMRU is strategically positioned to advance research toward this important strategic goal. 

The Thinwa lab studies neurotropic viruses, host defense pathways, autophagy and brain development

The Marciano laboratory investigates fundamental aspects of kidney development and regeneration, in both health and disease.

The research focus in the Corbin lab investigates strategies that exploits the deviant metabolism of cancer cells (namely the reprogramming of lipid metabolism and altered redox biology) for therapeutic purposes.

The Wakeland Lab utilizes state-of-the-art genomic strategies to investigate the diversity of the human and mouse immune systems.