Search

Minassian Lab has been involved in the identification and co-discovery of the causative gene mutations in over 20 different childhood neurological diseases. 

Skip to main content Lab Members Current Lab Members Jongwook Park, Ph.D. Postdoctoral Research Fellow Dr. Jongwook Park received his Ph.D. from Korea University, where he studied the mechanisms of antibiotic resistance in pathogens and microbiota-mediated maternal effects. He joined the Obata Lab in…

Mootha Lab uses human genetics and genomics to understand the molecular basis of Fuchs' endothelial corneal dystrophy and develop novel therapeutic strategies.

Xin Li, Ph.D., is an Assistant Professor (tenure-track) in the Department of Pediatrics at UT Southwestern Medical Center, with a secondary appointment in the Department of Immunology. His research interests lie in studying host-microbiota interactions in health and disease. Using innovative techniques in microbiology and immunology, and multiple model organisms (bacteria, fungi, drosophila, mice, and humans), his research aims to investigate the fundamental mechanisms by which gut commensal bacteria and fungi regulate local and systemic inflammatory immune responses.For his Ph.D., under the mentorship of Dr. Wendy Watford at the University of Georgia, Dr. Li studied the role of Tpl2, a host serine-threonine kinase, in modulating T regulatory and Th17 cell function, identifying a potential therapeutic target for autoimmune disorders. During his postdoctoral training at Weill Cornell Medical College, mentored by Dr. Iliyan Iliev and co-mentored by Dr. David Artis, he focused on the impact of gut commensal …

Skip to main content Publications Microbiota metabolism of intestinal amino acids impacts host nutrient homeostasis and physiology Author Collaboration JL, Li TT, Chen X, Huo D, Arifuzzaman M, Qiao S, Jin WB, Shi H, Li XV, Iliev ID, Artis D, Guo CJ 2024 May Cell Host and Microbe 32 661-675.e10 Author…

Our lab are studying host-microbe interactions and tissue immunity using multiple model organisms i) Identifying novel host factors involved in bacterial and fungal sensing to regulate inflammatory diseases. ii) Identifying new microbial factors involved in bacterial and fungal sensing to regulate inflammatory diseases. These factors may include pore-forming toxins and other toxins. iii) Identifying how microbe sensing of host-derived factors in the gut controls microbial commensalism and pathogenicity. iv) Utilizing fungi as a model system, genetic engineering of microbial effectors to understand how a microbe dictates protective immunity, and pathogenic immunity at tissue barriers.

Xin Li xin.li@utsouthwestern.eduUniversity of Texas Southwestern Medical Center5323 Harry Hines Blvd. K04.250Dallas, TX  75390-9063

Skip to main content News and Media Video feature: Meat Fight Fellow, Nancy Monson, Ph.D., and Star

Meet Principal Investigator Dr. Lawson Copley.

The Zia Research Group focuses on clinical and translational hematology research to improve the understanding of pediatric thrombotic and hemostatic disorders with the long-term goal of improving the lives of affected children and young adults with these disorders.