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The Whitehurst Lab uses RNAi-based functional genomics to identify gene products that support viability and/or modulate chemotherapeutic sensitivity in tumor cells. 

Meet the De Nisco-Zimmern Lab team.

We strive to decipher mechanisms of structural, functional, and electrical remodeling in heart disease with an eye toward therapeutic intervention. 

Contact the De Nisco-Zimmern Lab

Skip to main content Contact Us Principal Investigator Ashley Solmonson, Ph.D. Email Mailing Address UT Southwestern Medical Center 5323 Harry Hines Blvd. Building J, Room J6.114 Dallas, TX 75390-8511

Dr. Vega and co-workers have discovered three other causes of high LDL. First, she found that some patients have abnormal LDL particles that cannot be removed from circulation because the abnormal LDL does not recognize the receptors. 

Skip to main content Publications Featured Publications Solmonson A, Faubert B, Gu W, Rao A, Cowdin MA, Menendez-Montes I, Kelekar S, Rogers TJ, Pan C, Guevara G, Tarangelo A, Zacharias LG, Martin-Sandoval MS, Do D, Pachnis P, Dumesnil D, Mathews TP, Tasdogan A, Pham A, Cai L, Zhao Z, Ni M, Cleaver O…

Skip to main content Research Metabolic requirements of placental development and function The placenta is a critical metabolic organ that has been vastly understudied. Its primary function is to transport nutrients and oxygen to and waste products from the fetal circulation, but it must also grow ra…

A major focus of the Horton lab is to determine how these transcriptional regulators contribute to the development of steatosis in various disease processes such as diabetes, obesity, and beta-oxidation defects. A second area of investigation centers on determining the function of PCSK9, a protein that is involved in determining plasma LDL cholesterol levels through its ability to post-transcriptionally regulate the expression of the LDL receptor in liver.

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