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Skip to main content Meet the PI Matthew Mitsche, Ph.D. Assistant Professor, Center for Human Nutrition Molecular Genetics Matthew A. Mitsche earned his Ph.D. in 2012 from Boston University in Biophysics and Physiology where he studied the behavior of apolipoprotein fragments at lipid/water interface…

The central goal of the Dauer Lab is to unravel the molecular and cellular mechanisms of diseases that disrupt the motor system. In exploring these diseases, we also aim to understand a fundamental question relevant to CNS disease generally: what factors determine the selective vulnerability of particular cell types or circuits to insults? Our primary focus is on Parkinson’s disease and inherited forms of dystonia. We focus our efforts on disease genes that cause these disorders, employing a range of molecular, cellular, and whole animal studies to dissect the normal role of disease proteins, and how pathogenic mutations lead to disease.

Skip to main content Lab Members Former Lab Members Jami Keef Cesar Ortega Alvarez Mat Berger, Ph.D. Hatice Karaca Karabulut Preethi Chandrasekaran, Research Associate - UT Southwestern Medical Center Dallas Cameron Ward, Medical Student - UT Southwestern Medical Center Dallas Paige Long Sean Slater,…

Skip to main content Post-squalene Cholesterol Biosynthetic Pathways There has been an outstanding debate over the route of cholesterol biosynthesis since it was first discovered in the 1950s. Two alternative pathways have been proposed, the Bloch and Kandutsch-Russell pathways. Using deuterium water…

Skip to main content Lipid Assembly Fatty liver disease is a growing epidemic that has no effective treatment strategies. To date, most genetic variants associated with fatty liver have a role in the assembly and biosynthesis of lipids. Our lab studies mouse models of genetic variants associated with…

Dr. Waugh is a physician-scientist whose research focuses on the structural brain abnormalities that lead to dystonia, a movement disorder that leads muscles to twist and contort into painful positions.

The central goal of our studies is to unravel the molecular and cellular mechanisms of diseases that disrupt the motor system. In exploring these diseases, we also aim to understand a fundamental question relevant to CNS disease generally: what factors determine the selective vulnerability of particular cell types or circuits to insults? Our primary focus is on Parkinson’s disease and inherited forms of dystonia. We focus our efforts on disease genes that cause these disorders, employing a range of molecular, cellular, and whole animal studies to dissect the normal role of disease proteins, and how pathogenic mutations lead to disease.

Jer-Tsong Hsieh Lab research interests focus on key molecular mechanisms leading to urologic cancer progression, development of precision medicine of cancer therapy assisted with non-invasive molecular imaging.

Elizabeth Chen Lab focuses research on cell-cell fusion, drosophila myoblast fusion, invasive membrane protrusions, actin binding and bundling proteins, and mechanoresponsive proteins.

Skip to main content Flux Technology Measuring the rate of lipid biosynthesis has traditionally been done using radio-isotope labeling. While this technology is very sensitive, it is inherently dangerous due to the radioactivity and fairly non specific. Stable-isotope labeling provides an alternative…