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The Cobb lab studies signal transduction mechanisms of protein kinases and how kinase structures lead to cell biological functions. We are particularly focused on the contributions of ERK MAP kinases to pancreatic beta-cell function and to lung cancers, and on the cell biological actions of WNK protein kinases.

Skip to main content News See our latest Lab news . June 2025 The Azab Lab is presenting for the Southwestern Medical Foundation Trustees Today we had a fantastic opportunity to showcase our Lab's research to the Southwestern Medical Foundation Trustees, focusing on advancing localized therapies for …

Our research is aimed at innovating and translating computational technology to advance biomedical research and medical diagnoses/treatments.

Skip to main content Research_Tissue Engineering for Precision Medicine 3D Tissue Engineering Bone Marrow Culture (3DTEBM) In cancer drug development, despite promising results in vitro tissue culture models, many therapies fail to show the same efficacy in clinical trials in patients. The main reaso…

The discovery of ANP many years ago sparked interest in the use of natriuretic peptides to diagnose and treat heart failure and other salt-retaining disorders. Since then, there have been successes and failures. A more comprehensive understanding of the natriuretic peptide system, including the role of noncardiac factors such as race/ethnicity, may encourage more targeted approaches. One of the original insights of de Bold et al, was that the heart is an endocrine organ. Endocrine therapies are administered to individuals with specific evidence of endocrine dysfunction, not to capture short-term beneficial effects. For instance, thyroid hormone is given only to patients in whom hypothyroidism is demonstrated, not based on its metabolic actions. Studies are warranted to determine whether a similar strategy for the heart’s endocrine system can advance the prevention and treatment of cardiometabolic disease. CMRU is strategically positioned to advance research toward this important strategic goal. 

Skip to main content Meet the PI Xing Chao, Ph.D. Education / Training 1996-2000: Peking University, China, B.S., Biology 2001-2006: Case Western Reserve University, Ph.D., Genetic Epidemiology, Mentor: Robert C. Elston Positions 2014 - present: Associate Professor, UT Southwestern Medical Center, De…

Dr. Coughlin's Brain Health Program research focuses on molecular neuroimaging techniques, particularly the use of novel radiotracers with positron emission tomography (PET). Her team aims to inform the molecular understanding of neuropsychiatric conditions, and identify novel, precision therapies guided by imaging results. 

Dr. Cowell has built a research program focused on the development of bioinformatics and computational biology methods for studying the immune system and infectious diseases.  

Roberts Lab focuses on understanding the cellular and circuit mechanisms for behavioral learning, learning from social experiences and from example.

Skip to main content Research_Cancer Biology Mechanisms of Drug Resistance and Metastasis & Their Therapeutic Applications Drug resistance and metastasis are the most challenging aspects of cancer treatment. The dynamic interaction between the tumor cells and their tumor microenvironment (TME) plays …