Search

Zhu (Yuan) Lab Members

Skip to main content Neural-crest Stem Cells and Malignant Peripheral Nerve Sheath Tumor (MPNST) MPNST, a sarcoma arising from the neural-crest stem cell lineage in the peripheral nerve, is the leading cause of death for individuals with NF1. The presence of benign and premalignant lesions, namely, p…

Skip to main content Developing Neural Stem Cells and Pediatric Brain Tumors Pediatric low-grade gliomas (pLGGs) are the most common brain tumors in children, but rarely occur in adulthood. Genetically, pLGGs are a single molecular disease universally driven by abnormal activation of the RAS-RAF-MEK-…

In our lab, we focus on the mechanisms of cerebrovascular reactivity, exploring how blood vessels in the brain respond to changes in carbon dioxide, blood pressure, and other stimuli. 

In the Suleiman Lab, we focus on studying the podocyte biology, specifically the actin dynamics and cytoskeleton. Our research includes examining the balance of Rac and RhoA, two members of the Rho small GTPases, in both healthy and diseased kidneys. 

Engineered hydrogel biomaterials to improve tissue regeneration and disease modelling

The Leavey Lab focuses on clinical and translational trials in pediatric sarcoma.

Skip to main content Meet the Team Makoto Ishii, M.D., Ph.D. Principal Investigator & Assistant Professor Dr. Makoto Ishii is a board-certified neurologist and a physician-scientist dedicated to both patient care and biomedical research focusing primarily on Alzheimer’s disease and related neurodegen…

Skip to main content NF1-associated Autism (NF1-Autism) – Non-cancer Manifestations with TGS Syndromes Approximately 40%-70% of children with NF1 exhibit one or more forms of specific learning disabilities and 20%-45% have the features of autistic spectrum disorder (ASD). Thus, NF1 represents a uniqu…

Skip to main content Research Alzheimer's disease is the most common cause of dementia in the elderly and remains a devastating disease with currently no cure and limited therapeutic options. The exact pathogenesis of Alzheimer’s disease is being actively investigated, but a leading hypothesis is tha…