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Qi lab specializes in investigating the structure and function of membrane proteins related to human diseases using cryo-EM, cell-based assays, and mouse models.

Recent work from our laboratory and others has demonstrated that radiation effectively modifies the microenvironmental metabolism, subsequently influencing DNA damage repair responses. 

Skip to main content Lab Fun Laser tag (victorious vs the Nam lab!) Out in nature on a hike First group picture! Spring 2023 We moved down the hall! Don't look directly at the sun! Summer 2024 Taking at break from science to check out the birds (retreat 2024) Lab in summer 2023 Halloween 2024 Join Ou…

Skip to main content Get to know us! Meet the Principal Investigator Dan Kober, Ph.D. Dan joined the faculty in the Department of Biochemistry at UTSW in the fall of 2022. Before coming to Biochemistry, Dan earned his B.S. from Evangel University in Springfield, MO in 2012. He received his Ph.D. from…

Skip to main content Publications Structural basis for substrate selectivity by site-one protease revealed by studies with a small molecule inhibitor . Bullington AV , Micallo I, Bajaj B , Kumar P , Schlamowitz N , Silva A , Hendrix S, Zelcer N*, and Kober DL * . PNAS (2025). *Co-corresponding author…

Our research focuses on developing and testing novel immunotherapies for meningiomas (the most common brain tumors in adults) as well as on understanding the tumor immune microenvironment of meningiomas and other skull base tumors.

We anticipate this work to enhance functional recovery and improve the quality of life for trauma patients, while advancing our understanding of HO pathogenesis and normal tissue response to radiation.

Our laboratory is interested in understanding how the ubiquitin-mediated protein degradation regulates gene expression and how failure of these pathways contributes to developmental disorders and diseases, such as neurodegeneration and cancer.

Meet the Sharma Lab team

MUDIA Lab is focused on developing novel quantitative MRI techniques and analysis methods on CNS and musculoskeletal system.