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Our lab focuses on investigating the brain circuits implicated in treatment resistant depression with the ultimate goal of developing novel therapies for this devastating disease.

We are investigating how protein homeostasis (the maturation and turnover of enzymes) interacts with lipid homeostasis.

A major focus of the Horton lab is to determine how these transcriptional regulators contribute to the development of steatosis in various disease processes such as diabetes, obesity, and beta-oxidation defects. A second area of investigation centers on determining the function of PCSK9, a protein that is involved in determining plasma LDL cholesterol levels through its ability to post-transcriptionally regulate the expression of the LDL receptor in liver.

spinal cord injury, wound, pressure ulcer

Skip to main content Publications Recent Publications Singh A, Chandrasekar SV, Valappil VT, Scaria J, Ranjan A. Tumor immunomodulation by nanoparticle and focused ultrasound alters gut microbiome in a sexually dimorphic manner. Theranostics 2025; 15(1):216-232. (Featured on the journal cover) Singh …

Skip to main content Contact Main Office Department of Psychiatry Main Office University of Texas Southwestern Medical Center 2201 Inwood Road Dallas, Texas 75390 (214) 648-2806 Get directions Empire Building Clinic Multispecialty Psychiatry Clinic University of Texas Southwestern Medical Center 1430…

Skip to main content Contact Us Contact the Principal Investigator Ashish Ranjan, B.V.Sc., Ph.D. Endowed Professor Vice Chair for Comparative Oncology and Research Innovations Director of Veterinary Research and Oncology Clinic Email Lab: NC7.101 VROC Clinic: NF2.1

Skip to main content Join Us We are looking to fill several positions: Biomedical Engineering Postdoctoral Position Candidates must hold a Ph.D.; preference will be given to candidates who hold a Ph.D. specializing in therapeutic device development and possess qualifications in cancer biology. The po…

Skip to main content Research ASCEND Major depressive disorder (MDD) is ranked second among all diseases in global impact. Unfortunately, many patients have treatment-resistant MDD (TRD), for which the most effective antidepressant treatment option is electroconvulsive therapy (ECT). However, the neu…

The Liu Lab is Interested in developing and evaluating novel therapies, notably targeting tumor vasculatures.