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Dr. Mizuno's laboratory studies autonomic control of the cardiovascular system, particularly the underlying alterations in circulatory control in type 1 or type 2 diabetes and Alzheimer’s disease.

Skip to main content Publications The relationship between level of education and disease onset and progression in spinocerebellar ataxia types 1, 2, 3, and 6 Author Collaboration CC, Anderson CJ, Anderson DN, Kucharski A, Shakkottai V, Kuo SH, Rosenthal LS 2026 Jun Parkinsonism and Related Disorders…

Our lab are studying host-microbe interactions and tissue immunity using multiple model organisms i) Identifying novel host factors involved in bacterial and fungal sensing to regulate inflammatory diseases. ii) Identifying new microbial factors involved in bacterial and fungal sensing to regulate inflammatory diseases. These factors may include pore-forming toxins and other toxins. iii) Identifying how microbe sensing of host-derived factors in the gut controls microbial commensalism and pathogenicity. iv) Utilizing fungi as a model system, genetic engineering of microbial effectors to understand how a microbe dictates protective immunity, and pathogenic immunity at tissue barriers.

News fin the Tong Research Lab

Xin Li, Ph.D., is an Assistant Professor (tenure-track) in the Department of Pediatrics at UT Southwestern Medical Center, with a secondary appointment in the Department of Immunology. His research interests lie in studying host-microbiota interactions in health and disease. Using innovative techniques in microbiology and immunology, and multiple model organisms (bacteria, fungi, drosophila, mice, and humans), his research aims to investigate the fundamental mechanisms by which gut commensal bacteria and fungi regulate local and systemic inflammatory immune responses.For his Ph.D., under the mentorship of Dr. Wendy Watford at the University of Georgia, Dr. Li studied the role of Tpl2, a host serine-threonine kinase, in modulating T regulatory and Th17 cell function, identifying a potential therapeutic target for autoimmune disorders. During his postdoctoral training at Weill Cornell Medical College, mentored by Dr. Iliyan Iliev and co-mentored by Dr. David Artis, he focused on the impact of gut commensal …

We strive to decipher mechanisms of structural, functional, and electrical remodeling in heart disease with an eye toward therapeutic intervention. 

Skip to main content Publications Microbiota metabolism of intestinal amino acids impacts host nutrient homeostasis and physiology Author Collaboration JL, Li TT, Chen X, Huo D, Arifuzzaman M, Qiao S, Jin WB, Shi H, Li XV, Iliev ID, Artis D, Guo CJ 2024 May Cell Host and Microbe 32 661-675.e10 Author…

Skip to main content Publications Lafora disease gene therapy: EPM2A but not EPM2B overexpression results in Lafora body formation Alao EO, Sheibani M, Wu J, Marriam U, Evans D, Kasiri S, Verma M, Nitschke S, Nitschke F, Gray SJ, Mitra S, Minassian BA 2026 Mar Neurotherapeutics 23 CUL1 variants cause…

Skip to main content Lab Members Current Lab Members Jongwook Park, Ph.D. Postdoctoral Research Fellow Dr. Jongwook Park received his Ph.D. from Korea University, where he studied the mechanisms of antibiotic resistance in pathogens and microbiota-mediated maternal effects. He joined the Obata Lab in…

The Jain Lab is broadly interested in sex disparities in research on women's health, as well as the impact of sex hormones on airway diseases and immune response.