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Translational Research in UltraSound Theranostics (TRUST) Lab at UT Southwestern

The Center for Depression Research and Clinical Care (CDRC) is nationally recognized for its cutting-edge research in unipolar and bipolar depression. The research conducted within the center brings better understanding of the causes of depression, identifies effective new treatments, and improves existing ones.

Recruitment section of Farrar Lab.

Contact page for Farrar Lab

Publications from the Farrar Lab

Skip to main content Publications CDKL5 regulates p62-mediated selective autophagy and confers protection against neurotropic viruses Thinwa JW, Zou Z, Parks E, Sebti S, Hui KK, Wei Y, Goodarzi M, Singh V, Urquhart G, Jewell JL, Pfeiffer JK, Levine B, Reese TA, Shiloh MU. 2024 J Clin Invest Procyanid…

We are interested in the function of chromatin regulation of signaling pathways important for neural development, brain tumor growth and autism pathogenesis. 

We study ion channel clusters. To study such clusters without the complications arising from the complex cellular environment, components from cells are purified and studied in isolation.

Skip to main content People We believe that to do great science, all have to be welcome to the table. Each voice and each skill push us forward—together. Current Lab Members Josephine Thinwa, M.D., Ph.D. Principal Investigator Zhongju Zou, M.S. Senior Research Scientist Jason Lucavs Ph.D. Student Gio…

The discovery of ANP many years ago sparked interest in the use of natriuretic peptides to diagnose and treat heart failure and other salt-retaining disorders. Since then, there have been successes and failures. A more comprehensive understanding of the natriuretic peptide system, including the role of noncardiac factors such as race/ethnicity, may encourage more targeted approaches. One of the original insights of de Bold et al, was that the heart is an endocrine organ. Endocrine therapies are administered to individuals with specific evidence of endocrine dysfunction, not to capture short-term beneficial effects. For instance, thyroid hormone is given only to patients in whom hypothyroidism is demonstrated, not based on its metabolic actions. Studies are warranted to determine whether a similar strategy for the heart’s endocrine system can advance the prevention and treatment of cardiometabolic disease. CMRU is strategically positioned to advance research toward this important strategic goal.