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The central goal of the Dauer Lab is to unravel the molecular and cellular mechanisms of diseases that disrupt the motor system. In exploring these diseases, we also aim to understand a fundamental question relevant to CNS disease generally: what factors determine the selective vulnerability of particular cell types or circuits to insults? Our primary focus is on Parkinson’s disease and inherited forms of dystonia. We focus our efforts on disease genes that cause these disorders, employing a range of molecular, cellular, and whole animal studies to dissect the normal role of disease proteins, and how pathogenic mutations lead to disease.

recent and featured publications from the CMRU

The Callaway Lab studies how disruptions to lung development can predispose to long-term pathology.

The Calvier Lab's research focuses on endothelial modulation as a therapeutic approach to inflammatory diseases.

How do cells sense metabolites to drive their growth and proliferation?  We seek to study metabolites not only as nutrients but as cellular instruction signals that dictate cell biology. 

Our lab focuses on the use of cardiac magnetic resonance imaging (CMR) in pediatric and congenital heart disease.

The goal of the Choi Lab is to develop novel immunotherapies. To accomplish this, we first utilize high-dimensional approaches on human disease samples. This approach identifies targetable disease-promoting molecular defects in immune cells. Then, we utilize engineering approaches ot reverse the molecular changes.

Our research focuses on developing and translating computational neuroimaging methods to delineate human brain structure-function relationships. Current applications include identifying biomarkers of disease progression and treatment response in multiple sclerosis and other neurodegenerative diseases. 

Publications of the Nair-Gill Lab

Current research projects in the Nair-Gill Lab