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Invasive Podosomes and Myoblast Fusion Elizabeth H. Chen Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA I. OVERVIEW Myoblast fusion is critical for the development, maintenance, and regeneration of skeletal muscles. Despite th…

Mechanisms of myoblast fusion during muscle development Ji Hoon Kim1, Peng Jin1, Rui Duan1, and Elizabeth H. Chen1,2 1Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205 Abstract The development and regeneration of skeletal muscles requi…

Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial adhesion and lesion macrophage accumulation Yinyuan Ding1,2,3,*, Linzhang Huang4,*, Xunde Xian1,2,*, Ivan S. Yuhanna4, Catherine R. Wasser1,2, Michael Frotscher5, Chieko Mineo4, Philip W. Shaul4,†, and Joachim Herz…

Unveiling the Mechanisms of Cell-Cell Fusion Elizabeth H. Chen1* and Eric N. Olson2* Cell-cell fusion is fundamental to the development and physiology of multicellular organisms, but little is known of its mechanistic underpinnings. Recent studies have revealed that many proteins involved in cell-ce…

Towards a molecular pathway for myoblast fusion in Drosophila Elizabeth H. Chen1,2 and Eric N. Olson1 1Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA 2Department of Molecular Biology and Genetics, Johns H…

| PERSPECTIVES Sex and the Single Fly: A Perspective on the Career of Bruce S. Baker Deborah J. Andrew,* Elizabeth H. Chen,†,‡,§ Devanand S. Manoli,**,†† Lisa C. Ryner,‡‡ and Michelle N. Arbeitman§§,1 *Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21…

CELL SCIENCE AT A GLANCE The fusogenic synapse at a glance Ji Hoon Kim1 and Elizabeth H. Chen2,3,* ABSTRACT Cell–cell fusion is a fundamental process underlying fertilization, development, regeneration and physiology of metazoans. It is a multi-step process involving cell recognition and adhesion, …

Actin-propelled Invasive Membrane Protrusions Promote Fusogenic Protein Engagement During Cell-Cell Fusion Khurts Shilagardi1, Shuo Li1, Fengbao Luo1, Faiz Marikar1, Rui Duan1, Peng Jin1, Ji Hoon Kim1, Katherine Murnen1, and Elizabeth H. Chen1,* 1Dept. of Molecular Biology and Genetics, Johns Hopki…

JCB: Article The Rockefeller University Press   $30.00 J. Cell Biol. Vol. 199 No. 1  169–185 www.jcb.org/cgi/doi/10.1083/jcb.201204065 JCB 169 R. Duan and P. Jin contributed equally to this paper. Correspondence to Elizabeth H. Chen: echen@jhmi.edu Abbreviations used in this paper: AID, auto-inhibi…

Developmental Cell, Vol. 1, 705–715, November, 2001, Copyright 2001 by Cell Press Antisocial, an Intracellular Adaptor Protein, Is Required for Myoblast Fusion in Drosophila founder cells while the remaining twist-expressing cells become fusion competent (for reviews, see Baylies et al., 1998; Fra…