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Skip to main content GEF-H1-Dependent Regulation of Anti-Tumor Immunity We discovered that intracellular activation of the GEF-H1 signaling pathway induces immune responses and dendritic cell maturation similar to microbial pattern recognition receptors. GEF-H1 directed immunity emerges as a critical…

Skip to main content Research A Microtubule-Based Microbial Pattern Recognition System Our work has revealed polymorphisms that show that microbial defense systems could be linked to human autoimmune diseases. Find out more Development of Mucosal Immunity We study human genetic diversity associated w…

See photos of the Joachimiak Lab group

Skip to main content Development of Mucosal Immunity We study human genetic diversity associated with inflammatory bowel diseases to understand the principal mechanisms of mucosal immunity that control the intestinal barrier function and the microbiome. Immune responses control host defenses intestin…

Skip to main content Join Our Lab The Reinecker lab currently has opportunities for: PhD students Projects focus on new mechanisms of recognition of viral and bacterial pathogens and control of innate and adaptive immunity. Postdoctoral researcher Two postdoctoral training positions are available in …

Joachimiak Lab publications

Skip to main content Microbial Transcriptional Regulators Control Mucosal Host Defenses We demonstrated that Interferon regulatory factor (IRF)1 is a component of cyclic dinucleotide recognition that allows mucosal DCs to induce host defense through TH1 7 cells and shape protective immune responses i…

Skip to main content Lab Members Shuzhen Liu, Ph.D. Instructor Division of Digestive and Liver Diseases Department of Internal Medicine Shuzhen earned her Ph.D. in Rostock University/FBN, Germany, where she studied the role of NF-kB and C/EBP factors in pathogen-mediated activation of bovine interleu…

Skip to main content Contact Us Mailing Address 5323 Harry Hines Blvd. Dallas, TX 75390-8887 Phone: 214-645-5430 Fax: 214-648-2022 Email Dr. Reinecker

Skip to main content Research We study bacterial colonization of the intestinal tract, to understand how both benign and pathological bacteria affect their environment. Our long-term goal is to treat intestinal diseases by genetically engineering bacteria in vivo . Intestinal Biofilms Biofilms are co…