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Surface hydrolysis of poly(glycolic acid) meshes increases the seeding density of vascular smooth muscle cells Jinming Gao,1,2 Laura Niklason,1,2 Robert Langer1 1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 2Department of Anesthesia, Mass…

COMMUNICATIONS Surface Modification of Polyanhydride Microspheres JINMING GAO†,‡, LAURA NIKLASON†,‡, XIAO-MEI ZHAO§, AND ROBERT LANGER*,† Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Anesthesia, Massachusetts General Hospi…

Probing the Energetics of Dissociation of Carbonic Anhydrase-Ligand Complexes in the Gas Phase Jinming Gao,* Qinyuan (Quincey) Wu,# Jeffrey Carbeck,* Q. Paula Lei,# Richard D. Smith,# and George M. Whitesides* *Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusett…

Development of B-Lapachone Prodrugs forTherapyAgainst Human Cancer Cells with Elevated NAD(P)H:Quinone Oxidoreductase1Levels Kathryn E. Reinicke,1,2 Erik A. Bey,1,3 Melissa S. Bentle,1,4 JohnJ. Pink,1,3 Stephen T. Ingalls,4,6 Charles L. Hoppel,4,6,7 Rosana I. Misico,8 GiselaM. Arzac,8 Gerardo Burton…

An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by �-lapachone Erik A. Bey†‡§, Melissa S. Bentle¶, Kathryn E. Reinicke�, Ying Dong†‡, Chin-Rang Yang‡, Luc Girard††, John D. Minna††, William G. Bornmann‡‡, Jinming Gao‡, and David A. Boothman†‡§ †Departments…

Correlation between the Charge of Proteins in Solution and in the Gas Phase Investigated by Protein Charge Ladders, Capillary Electrophoresis, and Electrospray Ionization Mass Spectrometry Jeffrey D. Carbeck,† Joanne C. Severs,‡ Jinming Gao,† Qinyuan Wu,‡ Richard D. Smith,* ,‡ and George M. Whitesid…

Membrane-encased polymer millirods for sustained release of 5-fluorouracil Feng Qian, Norased Nasongkla, Jinming Gao Cancer-Targeted Drug Delivery Laboratory, Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 Received 10 November 2001;…

Carbonic Anhydrase-Inhibitor Binding: From Solution to the Gas Phase Qinyuan Wu,†,§ Jinming Gao,‡ Diane Joseph-McCarthy,‡ George B. Sigal,‡ James E. Bruce,† George M. Whitesides,*,‡ and Richard D. Smith*,† EnVironmental Molecular Sciences Laboratory Pacific Northwest National Laboratory Richland,…

Using Protein Charge Ladders To Estimate the Effective Charges and Molecular Weights of Proteins in Solution Jinming Gao and George M. Whitesides* Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138 This paper describes the use of capi…

Protein Charge Ladders, Capillary Electrophoresis, and the Role of Electrostatics in Biomolecular Recognition JEFFREY D. CARBECK, IAN J. COLTON, JINMING GAO, AND GEORGE M. WHITESIDES* Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138 Received September …