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Skip to main content Lab Members Shuzhen Liu, Ph.D. Instructor Division of Digestive and Liver Diseases Department of Internal Medicine Shuzhen earned her Ph.D. in Rostock University/FBN, Germany, where she studied the role of NF-kB and C/EBP factors in pathogen-mediated activation of bovine interleu…

Skip to main content Publications Featured Publications Bacterial Peptidoglycan Fragments Differentially Regulate Innate Immune Signaling. Bersch KL, DeMeester KE, Zagani R, Chen S, Wodzanowski KA, Liu S, Mashayekh S, Reinecker HC , Grimes CL, ACS Cent Sci 2021 Apr 7 4 688-696 GEF-H1 Signaling upon M…

Skip to main content Join Our Lab The Reinecker lab currently has opportunities for: PhD students Projects focus on new mechanisms of recognition of viral and bacterial pathogens and control of innate and adaptive immunity. Postdoctoral researcher Two postdoctoral training positions are available in …

Skip to main content Microbial Transcriptional Regulators Control Mucosal Host Defenses We demonstrated that Interferon regulatory factor (IRF)1 is a component of cyclic dinucleotide recognition that allows mucosal DCs to induce host defense through TH1 7 cells and shape protective immune responses i…

Skip to main content Development of Mucosal Immunity We study human genetic diversity associated with inflammatory bowel diseases to understand the principal mechanisms of mucosal immunity that control the intestinal barrier function and the microbiome. Immune responses control host defenses intestin…

Skip to main content GEF-H1-Dependent Regulation of Anti-Tumor Immunity We discovered that intracellular activation of the GEF-H1 signaling pathway induces immune responses and dendritic cell maturation similar to microbial pattern recognition receptors. GEF-H1 directed immunity emerges as a critical…

Skip to main content People Josephine Ni, M.D. Assistant Professor Department of Internal Medicine Department of Microbiology As a physician-scientist, Dr. Ni explores bacterial colonization of the healthy and inflamed intestinal tract with the goal of modulating the gut microbiota to treat intestina…

Skip to main content Microtubule-Based Microbial Pattern Recognition System Cells contain a reservoir of inactive GEF-H1 bound to microtubules that is activated by dephosphorylation to form signaling platforms for the activation of innate and cell-autonomous immunity. Muramyl-dipeptide (MDP) is the m…

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Joachimiak Lab publications