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Noninvasive Monitoring of Local Drug Release Using X-ray Computed Tomography: Optimization and In Vitro/In Vivo Validation AGATA SZYMANSKI-EXNER,1 NICHOLAS T. STOWE,2 KYLE SALEM,1 ROEE LAZEBNIK,1 JOHN R. HAAGA,3 DAVID L. WILSON,1 JINMING GAO1,3 1Department of Biomedical Engineering, Case Western R…

Enhancement of Solubility and Bioavailability of �-Lapachone Using Cyclodextrin Inclusion Complexes Norased Nasongkla,1,2 Andy F. Wiedmann,2 Andrew Bruening,3 Meghan Beman,3 Dale Ray,4 William G. Bornmann,5 David A. Boothman,3 and Jinming Gao2,6 Received June 11, 2003; Accepted June 19, 2003 Pur…

Journal of Controlled Release 91 (2003) 157–166 www.elsevier.com/ locate/ jconrel Q uantification of in vivo doxorubicin transport from PLGA millirods in thermoablated rat livers a ,1 b a a a ,*Feng Qian , Nicholas Stowe , Erin H. Liu , Gerald M. Saidel , Jinming Gao aDepartment of Biomedical Engin…

Bioorganic Chemistry cRGD-Functionalized Polymer Micelles for Targeted Doxorubicin Delivery** Norased Nasongkla, Xintao Shuai, Hua Ai, Brent D. Weinberg, John Pink, David A. Boothman, and Jinming Gao* Low water solubility, rapid phagocytic and renal clearance, and systemic toxicity represent three…

This article was published in an Elsevier journal. The attached copy is furnished to the author for non-commercial research and education use, including for instruction at the author’s institution, sharing with colleagues and providing to institution administration. Other uses, including reproducti…

Journal of Controlled Release 83 (2002) 415–425 www.elsevier.com/ locate/ jconrel N oninvasive monitoring of local drug release in a rabbit radiofrequency (RF) ablation model using X-ray computed tomography a b a aAgata Szymanski-Exner , Nicholas T. Stowe , Roee S. Lazebnik , Kyle Salem , a c a,c …

Membrane-encased polymer millirods for sustained release of 5-fluorouracil Feng Qian, Norased Nasongkla, Jinming Gao Cancer-Targeted Drug Delivery Laboratory, Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 Received 10 November 2001;…

Fabrication and characterization of controlled release poly(D,L-lactide-co-glycolide) millirods Feng Qian, Agata Szymanski, Jinming Gao Cancer-Targeted Drug Delivery Laboratory, Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 Receive…

In vivo drug distribution dynamics in thermoablated and normal rabbit livers from biodegradable polymers Jinming Gao,1 Feng Qian,1 Agata Szymanski-Exner,1 Nicholas Stowe,2 John Haaga3 1Cancer-Targeted Drug Delivery Laboratory, Department of Biomedical Engineering, Case Western Reserve University, C…

628 graft morphology and function have not been adequately addressed. A systematic understanding of the effects of in vitro parameters will be important if these culture tech- niques are to be translated to human cells for the develop- ment of autologous human vascular grafts that have acceptable lo…