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Read the paper by Xiao-Dong Li and Jiaxi Wu

Skip to main content Publications Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma. Cheng CC, Wooten J, Gibbs ZA, McGlynn K, Mishra P, Whitehurst AW, 2020 Sep Elife 9 The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncog…

Skip to main content Research A Microtubule-Based Microbial Pattern Recognition System Our work has revealed polymorphisms that show that microbial defense systems could be linked to human autoimmune diseases. Find out more Development of Mucosal Immunity We study human genetic diversity associated w…

Skip to main content Development of Mucosal Immunity We study human genetic diversity associated with inflammatory bowel diseases to understand the principal mechanisms of mucosal immunity that control the intestinal barrier function and the microbiome. Immune responses control host defenses intestin…

Skip to main content Microtubule-Based Microbial Pattern Recognition System Cells contain a reservoir of inactive GEF-H1 bound to microtubules that is activated by dephosphorylation to form signaling platforms for the activation of innate and cell-autonomous immunity. Muramyl-dipeptide (MDP) is the m…

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Skip to main content Join Us Become a Team Member The Whitehurst lab is seeking energetic, dedicated graduate students and postdoctoral fellows to join our work. Current Projects Cancer-Testis Antigens (aka Cancer Germline Genes) Cancer-testis antigens are normally only expressed in testis, but we ha…

Skip to main content GEF-H1-Dependent Regulation of Anti-Tumor Immunity We discovered that intracellular activation of the GEF-H1 signaling pathway induces immune responses and dendritic cell maturation similar to microbial pattern recognition receptors. GEF-H1 directed immunity emerges as a critical…