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The Briggs Laboratory at UT Southwestern studies how parasitic helminths shape host immunity, with a focus on the mechanisms that determine protective immunity, immune tolerance, and the broader bystander consequences of chronic infection. We integrate experimental models, human immunology, and field-based studies to understand how helminth-driven immune remodeling influences coexisting conditions such as cancer, coinfections, and vaccine responses, while translating mechanisms of immune tolerance into new therapeutic pathways for allergies and inflammatory diseases.

Contact the Wang (Jui-Kai) Lab.

Meet the PI, Qing Zhang, Ph.D.

Meet the PI, Kim Orth, Ph.D.

Meet the Orth Lab team.

The Briggs Laboratory at UT Southwestern studies how parasitic helminths shape host immunity, with a focus on the mechanisms that determine protective immunity, immune tolerance, and the broader bystander consequences of chronic infection. We integrate experimental models, human immunology, and field-based studies to understand how helminth-driven immune remodeling influences coexisting conditions such as cancer, coinfections, and vaccine responses, while translating mechanisms of immune tolerance into new therapeutic pathways for allergies and inflammatory diseases.

The Briggs Laboratory at UT Southwestern studies how parasitic helminths shape host immunity, with a focus on the mechanisms that determine protective immunity, immune tolerance, and the broader bystander consequences of chronic infection. We integrate experimental models, human immunology, and field-based studies to understand how helminth-driven immune remodeling influences coexisting conditions such as cancer, coinfections, and vaccine responses, while translating mechanisms of immune tolerance into new therapeutic pathways for allergies and inflammatory diseases.

The Briggs Laboratory at UT Southwestern studies how parasitic helminths shape host immunity, with a focus on the mechanisms that determine protective immunity, immune tolerance, and the broader bystander consequences of chronic infection. We integrate experimental models, human immunology, and field-based studies to understand how helminth-driven immune remodeling influences coexisting conditions such as cancer, coinfections, and vaccine responses, while translating mechanisms of immune tolerance into new therapeutic pathways for allergies and inflammatory diseases.

Our lab collaborates with a multidisciplinary group of researchers to study the heart and lungs long after preterm birth. 

Meet the Ghersi Lab team.