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Skip to main content Publications Featured Publications Evaluating Therapeutic Efficacy of the Vascular Disrupting Agent OXi8007 Against Kidney Cancer in Mice. Wanniarachchi HI, Schuetze R, Deng Y, Hamal KB, Pavlich CI, Tankoano PEO, Tamminga C, Hammers H, Kapur P, Bueno LMA, Rayas R, Wang T, Liu L, …

We are dedicated to uncovering how G protein–coupled receptors (GPCRs) regulate metabolism and contribute to health and disease. Our research aims to translate these discoveries into new insights and therapeutic strategies.

Children with in-born errors of immunity are prone to life-threatening viral, bacterial, and fungal infections. We study the causes of their immune system problems, combining clinical insights and mouse models genocopying the various mutations. This work includes a profiling of immune responses to infections (e.g., COVID-19) in normal healthy individuals along with different patient populations (e.g. 22q11.2 deletion syndrome).

Our lab is interested in addressing a fundamental question of cell biology: How are organelles spatially organized?

Skip to main content Publications Statistical Trends in Natural Product Synthesis Nathan Schmitt and Uttam K. Tambar Late-Stage Synthesis of Photoaffinity Labeling Probes Lauren M. Duncan, Debora Andrade-Silva, Mary W. N. Burns, Jennifer J. Kohler, and Uttam K. Tambar Read the ChemRxiv 2026 article S…

Skip to main content Publications Laterality and Sex Differences of Human Lateral Habenula Afferent and Efferent Fiber Tracts. Hitti FL, Parker D, Yang AI, Brem S, Verma R, 2022 Front Neurosci 16 837624 Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Treatment-Resistant Depression:…

Skip to main content People Meet the Principal Investigator Frederick Hitti, M.D., Ph.D. Frederick Hitti, M.D., Ph.D., is an Assistant Professor in the Departments of Neurological Surgery and Psychiatry at UT Southwestern Medical Center. Clinically, he specializes in epilepsy and movement disorders, …

Kitamura Lab's research aims to provide a biophysically-based mechanistic understanding of the neural process for learning and memory in the mouse brain.

We focus on the discovery of targeted therapies for major drivers of cancer using protein chemistry, enzymology, structural biology, informatics and cell biology. Some of our favorite targets are RAS and kinase proteins.

The goal of our research is to identify key immune checkpoints of gastrointestinal disorders that could be targeted for therapeutic intervention and drug development.