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Learn about Sreelatha Lab's research.

The Zechner Lab applies molecular and cell biology techniques to investigate how mammalian cells regulate their phosphate homeostasis and sensing using the ubiquitous phosphate transporter PiT1/SLC20A1 as a model.

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Skip to main content Mechanism and Regulation of Ribosome Biogenesis Ribosome biogenesis is one of the most intricate and energy-intensive processes in the cell. In our lab, we investigate how the large ribosomal subunit (60S) is assembled from RNA and proteins through a finely tuned series of enzyma…

Skip to main content tRNA Determinants of Co-Translational mRNA Decay Our lab is exploring how translation itself can shape the stability and lifetime of mRNAs, a process that directly links codon usage to gene expression. In collaboration with the Mendell lab, we discovered a new co-translational de…

Skip to main content Targeting Ribosome Biogenesis in Cancer Building on our mechanistic studies of ribosome assembly, we are investigating how small molecules can selectively inhibit key enzymatic steps in this process to block cancer cell growth. Our current focus is NVL, a conserved AAA⁺ ATPase th…

Sreelatha Lab publications.

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Read the Routzong Lab's publications