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The Cobb lab studies signal transduction mechanisms of protein kinases and how kinase structures lead to cell biological functions. We are particularly focused on the contributions of ERK MAP kinases to pancreatic beta-cell function and to lung cancers, and on the cell biological actions of WNK protein kinases.

Skip to main content For Patients Appointments To schedule an appointment with Dr. Gill, please contact the UTSW Dermatology Clinic at: Tel: 214 645 2400 Address: UTSW Dermatology Clinic, Professional Office Building 2 (POB2), 5939 Harry Hines Blvd (4th floor), Dallas, TX 75390 Research Participation…

The Jiang lab studies fundamental mechanisms governing how diverse cell types are generated from naive progenitor cells and how cells of different types are put together to form appropriate body structures such as limbs during embryonic development. The lab also studies how damaged cells are replenished by stem cells during tissue repair and organ regeneration in adult life. We are particularly interested in understanding how cells communicate with one another to influence their growth and fate determination and how miscommunication among different cells leads to developmental abnormality and cancer progression.

We conduct state-of-the-art clinical trials in the field of cardiovascular diseases, offering patients access to advanced clinical therapies that would otherwise not be available.

The main focus of the Minna Lab is translational (“bench to bedside”) cancer research aimed at developing new ways to diagnose, prevent, and treat lung cancer based on a detailed understanding of the molecular pathogenesis of lung cancer.

List of publications from the Gill Lab. 

The discovery of ANP many years ago sparked interest in the use of natriuretic peptides to diagnose and treat heart failure and other salt-retaining disorders. Since then, there have been successes and failures. A more comprehensive understanding of the natriuretic peptide system, including the role of noncardiac factors such as race/ethnicity, may encourage more targeted approaches. One of the original insights of de Bold et al, was that the heart is an endocrine organ. Endocrine therapies are administered to individuals with specific evidence of endocrine dysfunction, not to capture short-term beneficial effects. For instance, thyroid hormone is given only to patients in whom hypothyroidism is demonstrated, not based on its metabolic actions. Studies are warranted to determine whether a similar strategy for the heart’s endocrine system can advance the prevention and treatment of cardiometabolic disease. CMRU is strategically positioned to advance research toward this important strategic goal. 

Mirpuri Lab is focused on neonatal innate immunity and the role of maternal diet (mHFD), dietary metabolites and innate lymphoid cells in offspring outcomes.

Skip to main content Contact Us Principal Investigator Jennifer Gill, MD PhD Assistant Professor Email: Jennifer.Gill@UTSouthwestern.edu Mailing Address 5323 Harry Hines Blvd Dallas, TX 75390-9069 Physical Address 6000 Harry Hines Blvd NL8.138A Dallas, TX 75235

Our laboratory discovered a family of transcription factors called sterol regulatory element-binding proteins (SREBPs) that control cholesterol and fatty acid synthesis.