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Skip to main content Lab Projects Research in the D'Orso Lab focuses on understanding molecular mechanisms of transcriptional regulation and defining how these normal programs become deregulated during viral infections and disease states. Another aspect is on the host-pathogen interaction between vir…

Skip to main content Meet the Team Meet the Principal Investigator Ivan D'Orso, Ph.D. The D’Orso lab has extensive experience in studying mechanisms of gene regulation in the context of human health and disease. Two major areas of study have been: 1) the characterization of mechanisms regulating HIV-…

Skip to main content Research Research Overview The general interest of our lab is to understand mechanisms for regulation of signaling proteins through intra- and inter-molecular interactions. A major focus is on receptor-mediated signaling pathways involved in neuron development and axonal guidance…

Skip to main content Protocols In vitro RapGAP activity assay This is a real-time photometric assay based on (Webb MR et al, 1992, Biochem J.) and (Webb MR, 1992, PNAS) The detailed descriptions of this method is in this publication: Pascoe HG*, Wang Y* and Zhang X. In vitro assay for the Rap GTPase …

Skip to main content Publications for Xuewu Zhang, Ph.D. Regulation of STING activation by phosphoinositide and cholesterol. Li J, Tan JX, Chen ZJ, Zhang X, Bai XC, 2026 Feb Nature PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling. Tan JX, Lv B, Li J, Li T, Du F, Chen X, Zhan…

Skip to main content Publications Aspirin-ticagrelor use after mild acute ischemic stroke: Findings from the get with the guidelines-stroke registry. Liberman AL, Zhang C, Rostanski SK, Kamel H, Navi BB, Cheng NT, Sundararajan R, Messe SR, Fonarow GC, Prabhakaran S, Xian Y, 2026 Jan J Stroke Cerebrov…

Skip to main content Our Research Glioblastoma Core vs Margin Gene Sequencing Several large-scale sequencing efforts (e.g., The Cancer Genome Atlas, NCI) and now Next Generation Sequencing (NGS), which is now consistently performed on newly diagnosed GBM tumors have the goal of identifying genetic mu…

Skip to main content Meet the Team Meet the Principal Investigator Xuewu Zhang, Ph.D. Professor Department of Pharmacology, Department of Biophysics Email Current Lab Members Shun Liu Research Scientist Email Yan Yin Research Scientist Email Xiuling Wu, Ph.D. Postdoctoral Researcher Email Hui Zhang, …

Skip to main content Meet the Team Darin T. Okuda, M.D., M.Sc., F.A.A.N., F.A.N.A. Principal Investigator & Professor Dr. Darin Okuda received his Bachelor of Science and Master of Science degrees from the University of Hawaii. He obtained his Medical Degree from the University of Hawaii, John A. Bur…

Skip to main content Gallery PlexinD1/GIPC/myosin VI: oligomerization for transportation A comprehensive structural analyses show how PlexinD1 binds the adaptor protein GIPC1, releasing the autoinhibition in GIPC1 and promoting its interaction with the motor protein myosin VI. Surprisingly, GIPC and …