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Skip to main content Research Structure and Aggregation Traditionally, proteins have been regarded as rigid structures, whose final form was predicated on their amino acid sequence. But recent research has shown that some proteins are highly flexible in both shape and function. As these intrinsically…

Skip to main content Publications TGF-β controls alveolar type 1 epithelial cell plasticity and alveolar matrisome gene transcription in mice. Danielle A Callaway, Ian J Penkala, Su Zhou, Jonathan J Knowlton, Fabian Cardenas-Diaz, Apoorva Babu, Michael P Morley, Mariana Lopes, Benjamin A Garcia, Edwa…

Skip to main content Meet the Principal Investigator Łukasz A. Joachimiak, Ph.D. I earned my B.S. in biochemistry from the University of Wisconsin-Madison and my Ph.D. from the University of Washington, where I established computational tools to define the energetic and structural principles that und…

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Skip to main content Research Molecular Chaperones and Aggregation A major focus of our work is molecular chaperones – proteins that bind to proteins and alter their conformation. Dysfunction of chaperones or their substrate proteins is associated with many human diseases, so understanding how protei…

The Chen Lab studies how disruptions in RNA regulation drive childhood cancer. Our work focuses on understanding how defects in RNA synthesis, processing, and degradation reshape gene expression programs in pediatric tumors.

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Skip to main content Join Us We are currently recruiting postdoctoral scholars and graduate students. Learn more about the postdoctoral scholar position .

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