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"Balancing Immunosuppression and Infectious Risk in the Era of Biologics and Advanced Therapies: Lessons for the ID Clinician" Speaker: Gabriel Motoa, M.D. Fellow Advanced Fellowship in Transplant Infectious Diseases Columbia University Medical Center & Weill-Cornell Medicine About Gabriel Motoa: Dr. Motoa completed his Infectious Diseases fellowship at Massachusetts General Hospital and Brigham and Women’s Hospital. He earned his medical degree from Universidad del Valle School of Medicine in Colombia and completed his internal medicine residency training at the University of Miami/Jackson Memorial Hospital, where he was part of both the Global Health and Medical Education tracks. His research interests center on opportunistic infections in immunocompromised and transplant populations., powered by Localist, the Community Event Platform

"Understanding Post-Traumatic Stress Disorder: An Overview for the Geriatrician" Speaker: Jessica Voit, M.D. Assistant Professor of Internal Medicine Division of Geriatric Medicine Medical Director, Geriatrics Care Clinic UT Southwestern Medical Center About Jessica Voit: Dr. Voit holds a bachelor's degree in biology from the University of Texas at Dallas, which she earned magna cum laude. She received her medical degree at UT Southwestern Medical Center and completed internal medicine residency training at the University of Michigan in Ann Arbor, where she served as Chief Resident. She then obtained advanced training through a fellowship in geriatric medicine at UT Southwestern Medical Center. She joined the UT Southwestern faculty in 2018. Dr. Voit established and directs the Hospital Elder Life Program (HELP) which, in addition to improving the care of hospitalized older adults, helps educate trainees across the professional spectrum about the hazards of hospitalization of the elderly and t…

Probing the Effects of Molecular Tension on Protein Function in Cellulo Speaker: Brenton Hoffman, Ph.D. Abstract: In vivo, cells exist in a complex mechanical environment that is a source of applied forces and a means of mechanical support. Cells respond to these mechanical stimuli through a poorly understood process called mechanotransduction. A clearer understanding of this process will lead to improved methods for manipulating cell behavior in the contexts of engineered tissue constructs as well as mechanically sensitive disease states (e.g., cancer and atherosclerosis). As mechanotransduction is likely due to force-induced conformation changes in load-bearing proteins, we develop and use protein-based biosensors that exhibit force-dependent changes in the color of emitted light. This technology enables dynamic measurements of mechanical forces at the molecular level that are innately compatible with concepts and approaches common in molecular biology and biophysics, enabling mechanistic studie…

Adult Esophageal Dysphagia Evaluation and Management Presented by: Mary Grace Alip ACNP-BC Grace Alip, M.S.N., APRN, ACNP-BC, is an acute care nurse practitioner at UT Southwestern Medical Center Frisco, currently working in internal medicine and liver and digestive diseases. She was board-certified by the American Nurses Credentialing Center in 2011 and is licensed by the state of Texas. At the conclusion of this activity, the participant should be able to: - Provide an overview of the process for assessing and managing nonacute adult esophageal dysphagia. - Review thorough patient history, symptom assessment, and physical examination to classify dysphagia features and characteristics. - Highlight treatment strategies and the importance of an interdisciplinary in the management of dysphagia. - Recognize the evaluation approach and diagnostic modalities. - Discuss the causes and differential diagnoses. - Define and distinguish between oropharyngeal and esophageal dysphagia, highlighting the …

This session is mandatory for Recently Registered Users: Attendance is required if you've registered for a BioHPC account within the past month and haven't had training.Soon-to-Register Users: Attend to expedite the account activation process. Account Activation Process Online Registration: New users should register for an account online at BioHPC Registration. If you haven't registered yet, please do so here: https://portal.biohpc.swmed.edu/intranet/accounts/register/Limited Access: Upon registration, users will have limited access to the BioHPC web portal, allowing them to review guides and training materials.Training Session: Full login and storage access to BioHPC systems will be granted after attending the mandatory in-person training session. Important: Bring Your Laptop! Please bring your laptop to the session so you can follow along with hands-on examples and set up your access in real time. We recommend fully charging your laptop beforehand, as there may not be enough power outlets available fo…

America Saves Week Series During this webinar you will learn: -How to save for each goal -Get next steps for saving Sponsored By: Benefits & Wellness Department, powered by Localist, the Community Event Platform

This session is mandatory for Recently Registered Users: Attendance is required if you've registered for a BioHPC account within the past month and haven't had training.Soon-to-Register Users: Attend to expedite the account activation process. Account Activation Process Online Registration: New users should register for an account online at BioHPC Registration. If you haven't registered yet, please do so here: https://portal.biohpc.swmed.edu/intranet/accounts/register/Limited Access: Upon registration, users will have limited access to the BioHPC web portal, allowing them to review guides and training materials.Training Session: Full login and storage access to BioHPC systems will be granted after attending the mandatory in-person training session. Important: Bring Your Laptop! Please bring your laptop to the session so you can follow along with hands-on examples and set up your access in real time. We recommend fully charging your laptop beforehand, as there may not be enough power outlets available fo…

Talk title: Sequence-basis of transcription initiation in the human genome Speaker: Jian Zhou, PhD Assistant Professor Lyda Hill Department of Bioinformatics, UTSW Abstract: Transcription initiation is a process that is essential to ensuring the proper function of any gene, yet we still lack a unified understanding of sequence patterns and rules that explain most transcription start sites in the human genome. By predicting transcription initiation at base-pair resolution from sequences with a deep learning–inspired explainable model called Puffin, we show that a small set of simple rules can explain transcription initiation at most human promoters. We identify key sequence patterns that contribute to human promoter activity, each activating transcription with distinct position-specific effects. Furthermore, we explain the sequence basis of bidirectional transcription at promoters, identify the links between promoter sequence and gene expression variation across cell types, and explore the cons…

Talk Title: "What are Learning Health Systems and Why They will Outperform Other Approaches to Improving Health and Care" When: Thursday March 12, 2026, noon to 1 p.m. Where: E6.200 CME credit is available for all attendees, and complimentary lunch will be provided for those joining us in person. We are very pleased that our March Grand Rounds will feature Charles Friedman, Professor of Learning Health Sciences at the University of Michigan Medical School, where he directs the Knowledge Systems Laboratory. He was formerly Founding Chair of the Department of Learning Health Sciences and the Josiah Macy Jr. Professor of Medical Education. He holds joint appointments in the Schools of information and Public Health. He is editor-in-chief of the open-access journal Learning Health Systems and co-chair of the multi-national movement to Mobilize Computable Biomedical Knowledge. Grand Rounds Series: Second Thursday of every month, noon to 1 p.m. Please register to attend in-person or via Zoom., powered by Lo…

DAPHI Seminar Series: "New Approaches Towards T Cell Receptor Engineered Cancer Immunotherapies​" On behalf of the Data Science and Artificial Intelligence for Precision Health Initiative (DAPHI) – Immuno-informatics for Health Program, please see below an invitation to our April 2025 Seminar. We are excited that our April Seminar will feature Dr. James R. Heath, the President of the Institute for Systems Biology and a Professor in Molecualr & Medical Pharmacology at the University of California, Los Angeles (UCLA) Dr. Heath will present his talk “New Approaches Towards T Cell Receptor Engineered Cancer Immunotherapies" Bio: Dr. James R. Heath is President and Professor at the Institute for Systems Biology in Seattle. Heath also has the position of Professor of Molecular and Medical Pharmacology at UCLA. Formerly, he was the Elizabeth W. Gilloon Professor of Chemistry at Caltech, and served as co-director of the Parker Institute for Cancer Immunotherapy at UCLA until 2017. Heath has…