Research

>Division faculty and fellows are dedicated to the study of gynecologic cancers.
Division faculty and fellows are dedicated to the study of gynecologic cancers.

Research is a key component of the Division of Gynecologic Oncology’s academic mission and includes basic as well as clinical studies.

Translational Research

Translational research is being conducted in laboratories located in the Department of Obstetrics and Gynecology and Cecil H. and Ida Greeen Center for Reproductive Biology Sciences, as well as in the Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research in the Simmons Biomedical Research Building on the North Campus of UT Southwestern.

In these laboratories, faculty and fellows are evaluating the biologic effects of chemotherapy, genetic therapy, and immunotherapy on gynecologic malignancies. Scientific findings are used to develop and implement new methods for prevention, early detection, diagnosis, prognostic assessment, and treatment of cancers in the female reproductive tract.

Cancer researchers have access to an institutional review board (IRB) approved gynecologic oncology tumor bank, as well as facilities for tissue culture, in vitro, and in vivo tumor growth assays.

Clinical Research

In tandem with the laboratory, our faculty and fellows are active in clinical research on new therapeutics, molecular early detection of cancer, family genetic studies, chemoprevention, epidemiology, and population studies.

As a member institution of the national NRG Oncology organization, the Division has patients enrolled in National Cancer Institute-sponsored clinical protocols for the treatment of ovarian, uterine, and cervical and gestational trophoblastic cancers. Patients also have access to several pharmaceutical company-sponsored research trials for the treatment of gynecologic cancers.

From Lab to Bedside

The Division of Gynecologic Oncology participates in several Phase 1 clinical trials in pre-invasive and invasive gynecologic cancers and solid tumors. These trials are investigator initiated, institutional trials, or collaborations with pharmaceutical companies in the evaluation of drugs for the treatment of ovarian and cervical cancers. The Division Faculty are also involved in a broad range of translational laboratory work and are Principal Investigators of several clinical trials.

By performing interdisciplinary research like this, the Division of Gynecologic Oncology strives to transfer findings to and from the laboratory and bedside.