Secondary Faculty

Yuh Min Chook, Ph.D. • Lab Website •

Yuh Min Chook

The Chook Lab studies physical and cellular mechanisms of nuclear-cytoplasmic transport. We seek to understand molecular recognition in this system and to discover new classes of nuclear localization and export signals.

Diagram of cell membrane

W. Mike Henne, Ph.D. • Lab Website •

William Henne, Ph.D.

The Henne Lab studies how cellular membranes are sculpted during processes like vesicle budding, organelle biogenesis, and the formation of inter-organelle membrane contact sites. We employ both budding yeast and mammalian cellular systems to reveal molecular mechanisms of this membrane remodeling, and our main projects use combinations of cell biology, genetics, biochemistry, and structural biology to deeply understand cellular sculpting events.

Ryan Hibbs, Ph.D. • Lab Website •

Ryan Hibbs

Ryan’s lab studies the structural mechanisms underlying neurotransmitter receptor function. We are particularly interested in defining principles of allosteric activation and modulation, ion selectivity, and ligand recognition.

Diagram of cell receptor

Milo Lin, Ph.D. •  Lab Website  •

Milo Lin, Ph.D.

Milo's lab uses statistical mechanical and computational approaches to find performance limits of complex biological systems. These include the multi-scale mechanisms of protein folding, dynamics and aggregation (especially in neuro-toxicity and cell plasticity).

Lin Lab image

Xin Liu, Ph.D. •

Xin Liu

The Liu Lab studies high-order chromatin organizations and their impacts on eukaryotic transcription in both normal and diseased states. We focus on understanding the molecular and biophysical bases of the interplay between transcriptional regulation and chromatin dynamics including chromatin loop and heterochromatin formation.

Diagram of chromatin formation

Xuelian Luo, Ph.D. • Lab Website •

Xuelian Luo

The Luo laboratory studies the molecular mechanisms of intracellular signal transduction pathways using a combination of structural and biochemical approaches. Our research program currently focuses on two major areas: the spindle checkpoint and the Hippo tumor suppressor pathway.

Protein ribbon diagram

Yunsun Nam, Ph.D. • Lab Website •

Yunsun Nam

Our lab is interested in the biochemical and structural mechanisms in RNA-mediated gene regulation pathways important in development and cancer. We are currently focused on investigating how microRNAs are processed and regulated.

Diagram of microRNA function

Daniela Nicastro, Ph.D.  •

Daniela Nicastro, Ph.D.

The Nicastro lab develops and uses modern electron microscopy and image processing techniques in combination with molecular genetics and biochemistry to study the structure and function of macromolecular machines and organelles. We are particularly interested in the molecular mechanisms of ciliary motility and DNA repair.

Nicastro Lab image

Rama Ranganathan Ph.D. • Lab Website •

Rama Ragananatham

The Ranganathan Lab is interested in the design principles of biological systems, focusing on evolutionary principles of proteins and cellular signaling networks.

Protein ribbon diagrams

Kimberly Reynolds, Ph.D.  • Lab Website •

Rama Ragananatham
The Reynolds Lab uses statistical analysis, comparative genomics, and epistasis experiments to understand the architecture and evolution of cellular systems. We are particularly interested in the evolutionary constraints on central metabolism, and large cellular structures like the flagellum. 
Protein ribbon diagrams

Xuewu Zhang, Ph.D. • Lab Website •

Xuewu Zhang

We study how signals are transduced across the cell membrane by using crystallography in combination with other approaches, focusing on the axon guidance receptor plexin.

Diagram of cell membrane