The Chook Lab studies physical and cellular mechanisms of nuclear-cytoplasmic transport. We seek to understand molecular recognition in this system and to discover new classes of nuclear localization and export signals.
Ryan’s lab studies the structural mechanisms underlying neurotransmitter receptor function. We are particularly interested in defining principles of allosteric activation and modulation, ion selectivity, and ligand recognition.
The Henne lab studies how cellular membranes are sculpted during processes like vesicle budding, organelle biogenesis, and the formation of inter-organelle membrane contact sites. We employ both budding yeast and mammalian cellular systems to reveal molecular mechanisms of this membrane remodeling, and our main projects use combinations of cell biology, genetics, biochemistry, and structural biology to deeply understand cellular sculpting events.
The Liu lab studies high-order chromatin organizations and their impacts on eukaryotic transcription in both normal and diseased states. We focus on understanding the molecular and biophysical bases of the interplay between transcriptional regulation and chromatin dynamics including chromatin loop and heterochromatin formation.
Our lab is interested in the biochemical and structural mechanisms in RNA-mediated gene regulation pathways important in development and cancer. We are currently focused on investigating how microRNAs are processed and regulated.
The Ranganathan Lab is interested in the design principles of biological systems, focusing on evolutionary principles of proteins and cellular signaling networks.
We study how signals are transduced across the cell membrane by using crystallography in combination with other approaches, focusing on the axon guidance receptor plexin.