Faculty and Research

Chad Brautigam, Ph.D. • Email •  Lab Website

Chad Brautigam, Ph.D.

Chad’s lab uses biophysical methods to study protein-protein and protein-ligand interactions. He is also working to improve the presentation and analysis of biophysical data.

Brautigam Lab image

Kevin Gardner, Ph.D. • Email • Lab Website

lKevin Gardner, Ph.D.

The Gardner Lab studies the biophysical and biochemical basis of environmental sensing domains, exploring natural regulation, and developing methods of artificial control.

Gardner Lab image

Elizabeth Goldsmith, Ph.D. • Email • Lab Website

Elizabeth Goldsmith, Ph.D.

Betsy's lab studies how proteins are regulated by conformational changes, focusing on protein kinases and using crystallography, NMR, mass spectrometry, and biochemistry.

Goldsmith Lab image

Nick Grishin, Ph.D. • Email • Lab Website

Nick Grishin, Ph.D.

We work at the interface of biology, computer science, mathematics, and physics. Our group specializes in computational biology of proteins and combines sequence and structure analysis with evolutionary considerations to facilitate discoveries of biological significance. 

Khuloud Jaqaman, Ph.D. • Email •  Lab Website

Khuloud Jaqaman, Ph.D.

Khuloud's lab develops integrative approaches combining single-molecule and super-resolution imaging, computational image analysis, and mathematical modeling to investigate the contribution of cell-surface receptor organization and interactions to cell signaling.

Khuloud Jaqaman Science

Zbyszek Otwinowski, Ph.D.  • Email •  Lab Website

Zbyszek Otwinowski, Ph.D.

The main research focus of the Otwinowski Lab is on developing computational and statistical methods and protocols for macromolecular structure determination using X-ray crystallography.

Otwinowski Lab image

Luke Rice, Ph.D. • Email •  Lab Website

Luke Rice, Ph.D.

Luke’s lab studies microtubule dynamics, seeking to discover how complex behavior emerges from the biochemical properties of molecular components.

Rice Lab image

Jose Rizo-Rey, Ph.D. • Email • Lab Website

Jose Rizo-Rey, Ph.D.

Jose’s lab studies the molecular mechanisms of intracellular membrane fusion, with particular focus on neurotransmitter release and its regulation during presynaptic plasticity.

Rizo-Rey Lab image

Michael Rosen, Ph.D., Chair • Email • Lab Website

Michael Rosen, Ph.D.

The Rosen Lab studies the physical mechanisms of actin regulation. We seek to understand both the structure and dynamics of individual pathway components and also how and why those components are organized into micron-scale cellular assemblies.

Rosen Lab image

Dan Rosenbaum, Ph.D. • Email  • Lab Website

Dan Rosenbaum, Ph.D.

Dan's lab studies the structure and function of eukaryotic integral membrane proteins. The goal of his research is to understand how ligands and the membrane environment influence the conformational landscape of key membrane proteins involved in cellular signaling.

Diana Tomchick, Ph.D. • Email  •  Lab Website

Diana Tomchick, Ph.D.

Diana's lab is focused on the relationship of protein structure to biological function, primarily characterized via the technique of protein crystallography. She is also interested in improving protein crystallization techniques, crystallographic data acquisition, and experimental methods of phasing.

Tomchick Lab image

Hong Zhang, Ph.D. • Email

Hong Zhang, Ph.D.

Hong's lab studies structure-function of various enzymes and regulators of NAD metabolic pathways and how NAD in turn influences gene expression such as circadian clock-mediated transcription regulation.