Faculty and Research
Chad’s lab uses biophysical methods to study protein-protein and protein-ligand interactions. He is also working to improve the presentation and analysis of biophysical data.
Jan’s lab is interested in understanding the dynamics of protein-RNA complexes during ribosome biogenesis. We are particularly focused on the roles of ATPases in coordinating ribosomal RNA processing and remodeling events, and in signaling between the ribosome biogenesis pathway and the cell cycle machinery.
Kendra's lab uses NMR spectroscopy, protein chemistry and yeast genetics to determine the structures, dynamics and energetics of protein folding in complex physiological environments such as those involved in the initiation and progression of human disease.
Betsy's lab studies how proteins are regulated by conformational changes, focusing on protein kinases and using crystallography, NMR, mass spectrometry, and biochemistry.
We work at the interface of biology, computer science, mathematics, and physics. Our group specializes in computational biology of proteins and combines sequence and structure analysis with evolutionary considerations to facilitate discoveries of biological significance.
Khuloud's lab develops integrative approaches combining single-molecule and super-resolution imaging, computational image analysis, and mathematical modeling to investigate the contribution of cell-surface receptor organization and interactions to cell signaling.
Svetla McPhie is passionate in solving complex protein structures in close to physiological environment by Cryo-electron microscopy in combination with additional structural methods and biophysical techniques. The focus of her work is to resolve functional structures of membrane and membrane-associated complexes by Cryo-EM at near atomic resolution. This will bring us a step closer to personalized medicine and intelligent drug design by visualizing dynamic protein and protein-drug interactions at the atomic level.
The main research focus of the Otwinowski Lab is on developing computational and statistical methods and protocols for macromolecular structure determination using X-ray crystallography.
Luke’s lab studies microtubule dynamics, seeking to discover how complex behavior emerges from the biochemical properties of molecular components.
Jose’s lab studies the molecular mechanisms of intracellular membrane fusion, with particular focus on neurotransmitter release and its regulation during presynaptic plasticity.
The Rosen Lab studies the physical mechanisms of actin regulation. We seek to understand both the structure and dynamics of individual pathway components and also how and why those components are organized into micron-scale cellular assemblies.
Dan's lab studies the structure and function of eukaryotic integral membrane proteins. The goal of his research is to understand how ligands and the membrane environment influence the conformational landscape of key membrane proteins involved in cellular signaling.
Diana's lab is focused on the relationship of protein structure to biological function, primarily characterized via the technique of protein crystallography. She is also interested in improving protein crystallization techniques, crystallographic data acquisition, and experimental methods of phasing.
Hong's lab studies structure-function of various enzymes and regulators of NAD metabolic pathways and how NAD in turn influences gene expression such as circadian clock-mediated transcription regulation.