Significant Publications

Gardet A, Benita Y, Sands BE, Ballester I, Landry A, Stevens C, Kornezik JR, Rioux JD, Daly MJ, Xavier RJ, Podolsky DK. LRRK2 is involved in the interferon gamma response and host-response to pathogens. J. Immun. 2010; 185; 5577-5585; originally published online Oct 4, 2010; doi:10.4049/jimmunol.1000548.

Xavier RJ, Podolsky DK. Unraveling the Pathogenesis of Inflammatory Bowel Disease. Nature. 2007 Jul 26; 448(7152):427-34.

Barnich N, Aguirre JE, Reinecker HC, Xavier RJ, Podolsky DK. Membrane recruitment of NOD2 in intestinal epithelial cells is essential for NF-ĸB activation in muramyl dipeptide recognition. The Journal of Cell Biology. 2005 Jul 5;170(1):21-6.

Hisamatsu T, Suzuki M, Reinecker H-C, Nadeau WJ, McCormick BA, Podolsky DK. CARD15/NOD2 Functions as an Anti-bacterial Factor in Human Intestinal Epithelial Cells. Gastroenterol. 2003;124(4):993-1000.

Podolsky DK. Inflammatory Bowel Disease. New England Journal of Medicine. 2002;347(6):417-429.

Sands BE, Tremaine WJ, Sandborn WJ, Rutgeerts PJ, Hanauer SB, Mayer L, Targan SR, Podolsky DK. Infliximab in the Treatment of Severe, Steroid-Refractory Ulcerative Colitis: A Pilot Study. Inflammatory Bowel Disease. 2001;7:83-88.

Cario E, Podolsky DK. Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infection & Immunity. 2000 Dec;7010-7017.

Kinoshita K, Taupin DR, Itoh H, Podolsky DK. Distinct pathways of cell migration and anti-apoptotic response to epithelial injury: structure-function analysis of human intestinal trefoil factor. Mol Cell Biol. 2000;20:4680-4690.

Podolsky DK. Going the Distance – The Case for True Colorectal-Cancer Screening. N Engl J Med.  2000;343(3):207-208.

Taupin DR, Kinoshita K, Podolsky DK. Intestinal trefoil factor confers colonic epithelial resistance to apoptosis. PNAS. 2000;97(2):799-804.

Present DH, Rutgeerts PJ, Targan SR, Hanauer SB, Mayer L, van Hogezand RA, Podolsky DK, Sands BE, Brookman T, DeWoody KL, Schaible TF, van Deventer SJH. Infliximab for the treatment of fistulas in patients with Crohn’s disease. N Engl J Med. 1999;340:1398-405.

Taupin DR, Chyang-Wu D, Jeon W-K, Wang TC, Podolsky DK. The trefoil gene family are co-ordinately expressed immediate-early genes: EGF receptor- and MAP kinase-dependent inter-regulation. J Clin Invest. 1999;103:R31-R38.

Quirk DM, Barry MJ, Aserkoff B, Podolsky DK. Physician specialty and variations in the cost of treating patients with acute upper gastrointestinal bleeding. Gastroenterol. 1997;113(5):1443-1448.

Mashimo H, Wu DC, Podolsky DK, Fishman MC. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science. 1996;274:262-265.

Sands BE, Ogata H, Lynch-Devaney K, deBeaumont M, Podolsky DK. Molecular cloning of the rat intestinal trefoil factor gene: Characterization of an intestinal goblet cell associated promoter. J Biol Chem. 1995;270(16):9353-61.

Podolsky DK, Lobb R, King N, Benjamin C, Pepinsky B, Sehgal P, deBeaumont M. Attenuation of colitis in the cotton-top tamarin by anti-a4 monoclonal antibody. J Clin Invest. 1993;92:372-380.

Suemori S, Lynch-Devaney K, Podolsky DK. Identification and characterization of rat intestinal trefoil factor:  Tissue- and cell-specific member of the trefoil protein family. Proc Natl Acad Sci USA. 1991;88:11017-11021.

Suemori S, Ciacci C, Podolsky DK. Regulation of transforming growth factor expression in rat intestinal epithelial cell lines. J Clin Invest. 1991;87:2216-2221.

Koyama S, Podolsky DK. Differential expression of transforming growth factors a and b in rat intestinal epithelial cells:  Mirror-image gradients from crypt to villus. J Clin Invest. 1989;83:1768-1773.