Nuclear Medicine Division
The Nuclear Medicine Division at UT Southwestern Medical Center performs clinical imaging, therapy, and research as well as preclinical research using novel radiopharmaceuticals.
The clinical work is performed at Parkland Memorial Hospital, Zale Lipshy University Hospital, William P. Clements Jr. University Hospital, and the PET Imaging Services facility on the North Campus. Preclinical imaging occurs in the Bill and Rita Clements Advanced Medical Imaging Building in laboratories containing state-of-the-art small animal PET/CT and SPECT/CT scanners and radiochemistry equipment. Clinical research activities include PET and SPECT neuroimaging for various neurodegenerative disorders and whole body imaging for oncologic disorders.
Research in Nuclear Medicine
Current areas of preclinical research include development of and in vivo testing of novel radiotracers to measure beta cell mass and function, tissue fibrosis, tumor localization, and physiology. Other areas of investigation include application of radionuclide to enhance nanoparticle technology development and application, use of copper radionuclides in imaging of neurodegenerative diseases, traumatic brain injury, and for imaging and therapy in prostate cancer, and use of mouse models of estrogen deficiency or resistance combined with imaging to understand how sex steroids regulate bone mass and metabolism.
Preclinical studies are supported by synthetic chemistry and radiochemistry and frequently incorporate cell and molecular biology for a more comprehensive study of disease mechanisms and pathophysiology.