Publications

2013

Wilson, I.M., Vucic, E.A., Enfield, K.S., Thu, K.L., Zhang, Y.A., Chari, R., Lockwood, W.W., Radulovich, N., Starczynowski, D.T., Banath, J.P., Zhang, M., Pusic, A., Fuller, M., Lonergan, K.M., Rowbotham, D., Yee, J., English, J.C., Buys, T.P., Selamat, S.A., Laird-Offringa, I.A., Liu, P., Anderson, M., You, M., Tsao, M.S., Brown, C.J., Bennewith, K.L., Macaulay, C.E., Karsan, A., Gazdar, A.F., Lam, S., Lam, W.L., EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. Oncogene, 2013

Huffman, K., Martinez, E.D., Pre-Clinical Studies of Epigenetic Therapies Targeting Histone Modifiers in Lung Cancer. Front Oncol, 3: 235, 2013

Ribeiro, N., Sousa, S.R., Brekken, R.A., Monteiro, F.J., Role of SPARC in bone remodeling and cancer-related bone metastasis. J Cell Biochem, 2013

Dellinger, M.T., Meadows, S.M., Wynne, K., Cleaver, O., Brekken, R.A., Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature. PLoS One, 8: e74686, 2013

Coe, B.P., Thu, K.L., Aviel-Ronen, S., Vucic, E.A., Gazdar, A.F., Lam, S., Tsao, M.S., Lam, W.L., Genomic Deregulation of the E2F/Rb Pathway Leads to Activation of the Oncogene EZH2 in Small Cell Lung Cancer. PLoS One, 8: e71670, 2013

Gazdar, A.F., Minna, J.D., Precision medicine for cancer patients: lessons learned and the path forward. J Natl Cancer Inst, 105: 1262-3, 2013

Osborne, J.K., Larsen, J.E., Gonzales, J.X., Shames, D.S., Sato, M., Wistuba, II, Girard, L., Minna, J.D., Cobb, M.H., NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition. Oncogenesis, 2: e63, 2013

Myers, B.R., Sever, N., Chong, Y.C., Kim, J., Belani, J.D., Rychnovsky, S., Bazan, J.F., Beachy, P.A., Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response. Dev Cell, 26: 346-57, 2013

Aguilera, K.Y., Brekken, R.A., Recruitment and retention: factors that affect pericyte migration. Cell Mol Life Sci, 2013

Villalta, S.A., Lang, J., Kubeck, S., Kabre, B., Szot, G.L., Calderon, B., Wasserfall, C., Atkinson, M.A., Brekken, R.A., Pullen, N., Arch, R.H., Bluestone, J.A., Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function. Diabetes, 62: 2870-8, 2013

Wang, L., Chang, J., Varghese, D., Dellinger, M., Kumar, S., Best, A.M., Ruiz, J., Bruick, R., Pena-Llopis, S., Xu, J., Babinski, D.J., Frantz, D.E., Brekken, R.A., Quinn, A.M., Simeonov, A., Easmon, J., Martinez, E.D., A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun, 4: 2035, 2013

Ghayee, H.K., Bhagwandin, V.J., Stastny, V., Click, A., Ding, L.H., Mizrachi, D., Zou, Y.S., Chari, R., Lam, W.L., Bachoo, R.M., Smith, A.L., Story, M.D., Sidhu, S., Robinson, B.G., Nwariaku, F.E., Gazdar, A.F., Auchus, R.J., Shay, J.W., Progenitor Cell Line (hPheo1) Derived from a Human Pheochromocytoma Tumor. PLoS One, 8: e65624, 2013

Ma, X., Wang, Y.W., Zhang, M.Q., Gazdar, A.F., DNA methylation data analysis and its application to cancer research. Epigenomics, 5: 301-16, 2013

Kutluk Cenik, B., Ostapoff, K.T., Gerber, D.E., Brekken, R.A., BIBF 1120 (nintedanib), a triple angiokinase inhibitor, induces hypoxia but not EMT and blocks progression of preclinical models of lung and pancreatic cancer. Mol Cancer Ther, 12: 992-1001, 2013

Ding, L.H., Park, S., Peyton, M., Girard, L., Xie, Y., Minna, J.D., Story, M.D., Distinct transcriptome profiles identified in normal human bronchial epithelial cells after exposure to gamma-rays and different elemental particles of high Z and energy. BMC Genomics, 14: 372, 2013

Hooda, J., Cadinu, D., Alam, M.M., Shah, A., Cao, T.M., Sullivan, L.A., Brekken, R., Zhang, L., Enhanced heme function and mitochondrial respiration promote the progression of lung cancer cells. PLoS One, 8: e63402, 2013

Ostapoff, K.T., Awasthi, N., Cenik, B.K., Hinz, S., Dredge, K., Schwarz, R.E., Brekken, R.A., PG545, an angiogenesis and heparanase inhibitor, reduces primary tumor growth and metastasis in experimental pancreatic cancer. Mol Cancer Ther, 12: 1190-201, 2013

Osborne, J.K., Larsen, J.E., Shields, M.D., Gonzales, J.X., Shames, D.S., Sato, M., Kulkarni, A., Wistuba, II, Girard, L., Minna, J.D., Cobb, M.H., NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM. Proc Natl Acad Sci U S A, 110: 6524-9, 2013

Shien, K., Toyooka, S., Yamamoto, H., Soh, J., Jida, M., Thu, K.L., Hashida, S., Maki, Y., Ichihara, E., Asano, H., Tsukuda, K., Takigawa, N., Kiura, K., Gazdar, A.F., Lam, W.L., Miyoshi, S., Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells. Cancer Res, 73: 3051-61, 2013

Currier, M.A., Eshun, F.K., Sholl, A., Chernoguz, A., Crawford, K., Divanovic, S., Boon, L., Goins, W.F., Frischer, J.S., Collins, M.H., Leddon, J.L., Baird, W.H., Haseley, A., Streby, K.A., Wang, P.Y., Hendrickson, B.W., Brekken, R.A., Kaur, B., Hildeman, D., Cripe, T.P., VEGF blockade enables oncolytic cancer virotherapy in part by modulating intratumoral myeloid cells. Mol Ther, 21: 1014-23, 2013

Chatterjee, S., Heukamp, L.C., Siobal, M., Schottle, J., Wieczorek, C., Peifer, M., Frasca, D., Koker, M., Konig, K., Meder, L., Rauh, D., Buettner, R., Wolf, J., Brekken, R.A., Neumaier, B., Christofori, G., Thomas, R.K., Ullrich, R.T., Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer. J Clin Invest, 123: 1732-40, 2013

Sato, M., Larsen, J.E., Lee, W., Sun, H., Shames, D.S., Dalvi, M.P., Ramirez, R.D., Tang, H., Dimaio, J.M., Gao, B., Xie, Y., Wistuba, II, Gazdar, A.F., Shay, J.W., Minna, J.D., Human Lung Epithelial Cells Progressed to Malignancy through Specific Oncogenic Manipulations. Mol Cancer Res, 11: 638-50, 2013

Kim, H.S., Minna, J.D., White, M.A., GWAS meets TCGA to illuminate mechanisms of cancer predisposition. Cell, 152: 387-9, 2013

Konstantinidou, G., Ramadori, G., Torti, F., Kangasniemi, K., Ramirez, R.E., Cai, Y., Behrens, C., Dellinger, M.T., Brekken, R.A., Wistuba, II, Heguy, A., Teruya-Feldstein, J., Scaglioni, P.P., RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas. Cancer Discov, 3: 444-57, 2013

Tang, H., Xiao, G., Behrens, C., Schiller, J., Allen, J., Chow, C.W., Suraokar, M., Corvalan, A., Mao, J., White, M.A., Wistuba, II, Minna, J.D., Xie, Y., A 12-gene set predicts survival benefits from adjuvant chemotherapy in non-small cell lung cancer patients. Clin Cancer Res, 19: 1577-86, 2013

Said, N., Frierson, H.F., Sanchez-Carbayo, M., Brekken, R.A., Theodorescu, D., Loss of SPARC in bladder cancer enhances carcinogenesis and progression. J Clin Invest, 123: 751-66, 2013

Kim, J., Aftab, B.T., Tang, J.Y., Kim, D., Lee, A.H., Rezaee, M., Kim, J., Chen, B., King, E.M., Borodovsky, A., Riggins, G.J., Epstein, E.H., Jr., Beachy, P.A., Rudin, C.M., Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell, 23: 23-34, 2013

Takahashi, T., Shivapurkar, N., Reddy, J., Shigematsu, H., Miyajima, K., Suzuki, M., Toyooka, S., Zochbauer-Muller, S., Drach, J., Parikh, G., Zheng, Y., Feng, Z., Kroft, S.H., Timmons, C., McKenna, R.W., Gazdar, A.F., Retraction: DNA methylation profiles of lymphoid and hematopoietic malignancies. Clin Cancer Res, 19: 307, 2013

Li, X., Zhou, Q., Hanus, J., Anderson, C., Zhang, H., Dellinger, M., Brekken, R., Wang, S., Inhibition of multiple pathogenic pathways by histone deacetylase inhibitor SAHA in a corneal alkali-burn injury model. Mol Pharm, 10: 307-18, 2013

Yoshida, K., Sato, M., Hase, T., Elshazley, M., Yamashita, R., Usami, N., Taniguchi, T., Yokoi, K., Nakamura, S., Kondo, M., Girard, L., Minna, J.D., Hasegawa, Y., TIMELESS is overexpressed in lung cancer and its expression correlates with poor patient survival. Cancer Sci, 104: 171-7, 2013

Byers, L.A., Diao, L., Wang, J., Saintigny, P., Girard, L., Peyton, M., Shen, L., Fan, Y., Giri, U., Tumula, P.K., Nilsson, M.B., Gudikote, J., Tran, H., Cardnell, R.J., Bearss, D.J., Warner, S.L., Foulks, J.M., Kanner, S.B., Gandhi, V., Krett, N., Rosen, S.T., Kim, E.S., Herbst, R.S., Blumenschein, G.R., Lee, J.J., Lippman, S.M., Ang, K.K., Mills, G.B., Hong, W.K., Weinstein, J.N., Wistuba, II, Coombes, K.R., Minna, J.D., Heymach, J.V., An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance. Clin Cancer Res, 19: 279-90, 2013

Travis, W.D., Brambilla, E., Noguchi, M., Nicholson, A.G., Geisinger, K., Yatabe, Y., Ishikawa, Y., Wistuba, I., Flieder, D.B., Franklin, W., Gazdar, A., Hasleton, P.S., Henderson, D.W., Kerr, K.M., Petersen, I., Roggli, V., Thunnissen, E., Tsao, M., Diagnosis of lung cancer in small biopsies and cytology: implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. Arch Pathol Lab Med, 137: 668-84, 2013

Dasgupta, S., Jang, J.S., Shao, C., Mukhopadhyay, N.D., Sokhi, U.K., Das, S.K., Brait, M., Talbot, C., Yung, R.C., Begum, S., Westra, W.H., Hoque, M.O., Yang, P., Yi, J.E., Lam, S., Gazdar, A.F., Fisher, P.B., Jen, J., Sidransky, D., SH3GL2 is frequently deleted in non-small cell lung cancer and downregulates tumor growth by modulating EGFR signaling. J Mol Med (Berl), 91: 381-93, 2013

Sunaga, N., Kaira, K., Imai, H., Shimizu, K., Nakano, T., Shames, D.S., Girard, L., Soh, J., Sato, M., Iwasaki, Y., Ishizuka, T., Gazdar, A.F., Minna, J.D., Mori, M., Oncogenic KRAS-induced epiregulin overexpression contributes to aggressive phenotype and is a promising therapeutic target in non-small-cell lung cancer. Oncogene, 32: 4034-42, 2013

Sugalski, A., Davis, M., Prasannan, L., Saldivar, V., Hung, J.Y., Tomlinson, G.E., Clinical, histologic, and genetic features of mesothelioma in a 7-year-old child. Pediatr Blood Cancer, 60: 146-8, 2013

Travis, W.D., Brambilla, E., Noguchi, M., Nicholson, A.G., Geisinger, K., Yatabe, Y., Ishikawa, Y., Wistuba, I., Flieder, D.B., Franklin, W., Gazdar, A., Hasleton, P.S., Henderson, D.W., Kerr, K.M., Nakatani, Y., Petersen, I., Roggli, V., Thunnissen, E., Tsao, M., Diagnosis of lung adenocarcinoma in resected specimens: implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. Arch Pathol Lab Med, 137: 685-705, 2013

2012

Hu, Y., Martinez, E.D., MacMillan, J.B., Anthraquinones from a marine-derived Streptomyces spinoverrucosus. J Nat Prod, 75: 1759-64, 2012

Liu, J., Lee, W., Jiang, Z., Chen, Z., Jhunjhunwala, S., Haverty, P.M., Gnad, F., Guan, Y., Gilbert, H.N., Stinson, J., Klijn, C., Guillory, J., Bhatt, D., Vartanian, S., Walter, K., Chan, J., Holcomb, T., Dijkgraaf, P., Johnson, S., Koeman, J., Minna, J.D., Gazdar, A.F., Stern, H.M., Hoeflich, K.P., Wu, T.D., Settleman, J., de Sauvage, F.J., Gentleman, R.C., Neve, R.M., Stokoe, D., Modrusan, Z., Seshagiri, S., Shames, D.S., Zhang, Z., Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events. Genome Res, 22: 2315-27, 2012

Byers, L.A., Wang, J., Nilsson, M.B., Fujimoto, J., Saintigny, P., Yordy, J., Giri, U., Peyton, M., Fan, Y.H., Diao, L., Masrorpour, F., Shen, L., Liu, W., Duchemann, B., Tumula, P., Bhardwaj, V., Welsh, J., Weber, S., Glisson, B.S., Kalhor, N., Wistuba, II, Girard, L., Lippman, S.M., Mills, G.B., Coombes, K.R., Weinstein, J.N., Minna, J.D., Heymach, J.V., Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1. Cancer Discov, 2: 798-811, 2012

Rudin, C.M., Durinck, S., Stawiski, E.W., Poirier, J.T., Modrusan, Z., Shames, D.S., Bergbower, E.A., Guan, Y., Shin, J., Guillory, J., Rivers, C.S., Foo, C.K., Bhatt, D., Stinson, J., Gnad, F., Haverty, P.M., Gentleman, R., Chaudhuri, S., Janakiraman, V., Jaiswal, B.S., Parikh, C., Yuan, W., Zhang, Z., Koeppen, H., Wu, T.D., Stern, H.M., Yauch, R.L., Huffman, K.E., Paskulin, D.D., Illei, P.B., Varella-Garcia, M., Gazdar, A.F., de Sauvage, F.J., Bourgon, R., Minna, J.D., Brock, M.V., Seshagiri, S., Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nat Genet, 2012

Gerber, D.E., Gupta, P., Dellinger, M.T., Toombs, J.E., Peyton, M., Duignan, I., Malaby, J., Bailey, T., Burns, C., Brekken, R.A., Loizos, N., Stromal platelet-derived growth factor receptor alpha (PDGFRalpha) provides a therapeutic target independent of tumor cell PDGFRalpha expression in lung cancer xenografts. Mol Cancer Ther, 2012

Sharma, V., Shivalingaiah, S., Peng, Y., Euhus, D., Gryczynski, Z., Liu, H., Auto-fluorescence lifetime and light reflectance spectroscopy for breast cancer diagnosis: potential tools for intraoperative margin detection. Biomed Opt Express, 3: 1825-40, 2012

Kirane, A., Toombs, J.E., Ostapoff, K., Carbon, J.G., Zaknoen, S., Braunfeld, J., Schwarz, R.E., Burrows, F.J., Brekken, R.A., Apricoxib, a Novel Inhibitor of COX-2, Markedly Improves Standard Therapy Response in Molecularly Defined Models of Pancreatic Cancer. Clin Cancer Res, 18: 5031-42, 2012

Thunnissen, E., Beasley, M.B., Borczuk, A.C., Brambilla, E., Chirieac, L.R., Dacic, S., Flieder, D., Gazdar, A., Geisinger, K., Hasleton, P., Ishikawa, Y., Kerr, K.M., Lantejoul, S., Matsuno, Y., Minami, Y., Moreira, A.L., Motoi, N., Nicholson, A.G., Noguchi, M., Nonaka, D., Pelosi, G., Petersen, I., Rekhtman, N., Roggli, V., Travis, W.D., Tsao, M.S., Wistuba, I., Xu, H., Yatabe, Y., Zakowski, M., Witte, B., Kuik, D.J., Reproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma. An international interobserver study. Mod Pathol, 2012

Tomlinson, G.E., Kappler, R., Genetics and epigenetics of hepatoblastoma. Pediatr Blood Cancer, 59: 785-92, 2012

Hezel, A.F., Deshpande, V., Zimmerman, S.M., Contino, G., Alagesan, B., O'Dell, M.R., Rivera, L.B., Harper, J., Lonning, S., Brekken, R.A., Bardeesy, N., TGF-beta and alphavbeta6 Integrin Act in a Common Pathway to Suppress Pancreatic Cancer Progression. Cancer Res, 72: 4840-5, 2012

Du, L., Subauste, M.C., DeSevo, C., Zhao, Z., Baker, M., Borkowski, R., Schageman, J.J., Greer, R., Yang, C.R., Suraokar, M., Wistuba, II, Gazdar, A.F., Minna, J.D., Pertsemlidis, A., miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers. PLoS One, 7: e39167, 2012

Awasthi, N., Zhang, C., Ruan, W., Schwarz, M.A., Schwarz, R.E., Evaluation of poly-mechanistic antiangiogenic combinations to enhance cytotoxic therapy response in pancreatic cancer. PLoS One, 7: e38477, 2012

Yao, Y., Fan, Y., Wu, J., Wan, H., Wang, J., Lam, S., Lam, W.L., Girard, L., Gazdar, A.F., Wu, Z., Zhou, Q., Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis. Biochem Biophys Res Commun, 423: 613-9, 2012

Hu, J., Lu, J.Y., Wong, A.M., Hynan, L.S., Birnbaum, S.G., Yilmaz, D.S., Streit, B.M., Lenartowicz, E.M., Thompson, T.C., Cooper, J.D., Hofmann, S.L., Intravenous high-dose enzyme replacement therapy with recombinant palmitoyl-protein thioesterase reduces visceral lysosomal storage and modestly prolongs survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis. Mol Genet Metab, 107: 213-21, 2012

Jeong, Y., Xie, Y., Lee, W., Bookout, A.L., Girard, L., Raso, G., Behrens, C., Wistuba, II, Gadzar, A.F., Minna, J.D., Mangelsdorf, D.J., Research resource: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer. Mol Endocrinol, 26: 1443-54, 2012

Chlebowski, R.T., McTiernan, A., Wactawski-Wende, J., Manson, J.E., Aragaki, A.K., Rohan, T., Ipp, E., Kaklamani, V.G., Vitolins, M., Wallace, R., Gunter, M., Phillips, L.S., Strickler, H., Margolis, K., Euhus, D.M., Diabetes, metformin, and breast cancer in postmenopausal women. J Clin Oncol, 30: 2844-52, 2012

Kirane, A., Toombs, J.E., Larsen, J.E., Ostapoff, K.T., Meshaw, K.R., Zaknoen, S., Brekken, R.A., Burrows, F.J., Epithelial-mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib. Carcinogenesis, 33: 1639-46, 2012

Lockwood, W.W., Wilson, I.M., Coe, B.P., Chari, R., Pikor, L.A., Thu, K.L., Solis, L.M., Nunez, M.I., Behrens, C., Yee, J., English, J., Murray, N., Tsao, M.S., Minna, J.D., Gazdar, A.F., Wistuba, II, MacAulay, C.E., Lam, S., Lam, W.L., Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development. PLoS One, 7: e37775, 2012

Selamat, S.A., Chung, B.S., Girard, L., Zhang, W., Zhang, Y., Campan, M., Siegmund, K.D., Koss, M.N., Hagen, J.A., Lam, W.L., Lam, S., Gazdar, A.F., Laird-Offringa, I.A., Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. Genome Res, 22: 1197-1211, 2012

Lynn, K.D., Brekken, R.A., Anti-VEGF therapy revived by c-Met inhibition, but is c-Met the answer? Cancer Discov, 2: 211-3, 2012

Elshazley, M., Sato, M., Hase, T., Yamashita, R., Yoshida, K., Toyokuni, S., Ishiguro, F., Osada, H., Sekido, Y., Yokoi, K., Usami, N., Shames, D.S., Kondo, M., Gazdar, A.F., Minna, J.D., Hasegawa, Y., The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma. Int J Cancer, 2012

Asterholm, I.W., McDonald, J., Blanchard, P.G., Sinha, M., Xiao, Q., Mistry, J., Rutkowski, J.M., Deshaies, Y., Brekken, R.A., Scherer, P.E., Lack of "immunological fitness" during fasting in metabolically challenged animals. J Lipid Res, 53: 1254-67, 2012

Sun, K., Asterholm, I.W., Kusminski, C.M., Bueno, A.C., Wang, Z.V., Pollard, J.W., Brekken, R.A., Scherer, P.E., Dichotomous effects of VEGF-A on adipose tissue dysfunction. Proc Natl Acad Sci U S A, 2012

Schwarz, M.A., Thornton, J., Xu, H., Awasthi, N., Schwarz, R.E., Cell proliferation and migration are modulated by Cdk-1-phosphorylated endothelial-monocyte activating polypeptide II. PLoS One, 7: e33101, 2012

Thu, K.L., Vucic, E.A., Chari, R., Zhang, W., Lockwood, W.W., English, J.C., Fu, R., Wang, P., Feng, Z., Macaulay, C.E., Gazdar, A.F., Lam, S., Lam, W.L., Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability. PloS one, 7: e33003, 2012

Euhus, D., Managing the breast in patients who test positive for hereditary breast cancer. Ann Surg Oncol, 19: 1738-44, 2012

Masciari, S., Dillon, D.A., Rath, M., Robson, M., Weitzel, J.N., Balmana, J., Gruber, S.B., Ford, J.M., Euhus, D., Lebensohn, A., Telli, M., Pochebit, S.M., Lypas, G., Garber, J.E., Breast cancer phenotype in women with TP53 germline mutations: a Li-Fraumeni syndrome consortium effort. Breast Cancer Res Treat, 133: 1125-30, 2012

Xie, Y., Minna, J.D., A lung cancer molecular prognostic test ready for prime time. Lancet, 379: 785-7, 2012

Arnold, S.A., Rivera, L.B., Carbon, J.G., Toombs, J.E., Chang, C.L., Bradshaw, A.D., Brekken, R.A., Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGFbeta activation. PLoS One, 7: e31384, 2012

Li, G., Guillaud, M., le Riche, J., McWilliams, A., Gazdar, A., Lam, S., Macaulay, C., Automated sputum cytometry for detection of intraepithelial neoplasias in the lung. Analytical cellular pathology, 2012

Benson, D.D., Beck, A.W., Burdine, M.S., Brekken, R., Silliman, C.C., Barnett, C.C., Jr., Accumulation of pro-cancer cytokines in the plasma fraction of stored packed red cells. J Gastrointest Surg, 16: 460-8, 2012

Tomlinson, G.E., Cytogenetics of hepatoblastoma. Front Biosci (Elite Ed), 4: 1287-92, 2012

Allen, J.D., Wang, S., Chen, M., Girard, L., Minna, J.D., Xie, Y., Xiao, G., Probe mapping across multiple microarray platforms. Brief Bioinform, 13: 547-54, 2012

Chang, J., Varghese, D.S., Gillam, M.C., Peyton, M., Modi, B., Schiltz, R.L., Girard, L., Martinez, E.D., Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide. Br J Cancer, 106: 116-25, 2012

Horio, M., Sato, M., Takeyama, Y., Elshazley, M., Yamashita, R., Hase, T., Yoshida, K., Usami, N., Yokoi, K., Sekido, Y., Kondo, M., Toyokuni, S., Gazdar, A.F., Minna, J.D., Hasegawa, Y., Transient but Not Stable ZEB1 Knockdown Dramatically Inhibits Growth of Malignant Pleural Mesothelioma Cells. Ann Surg Oncol, 19 Suppl 3: 634-45, 2012

Li, Y., Martin, B.R., Cravatt, B.F., Hofmann, S.L., DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells. J Biol Chem, 287: 523-30, 2012

Kirov, A., Al-Hashimi, H., Solomon, P., Mazur, C., Thorpe, P.E., Sims, P.J., Tarantini, F., Kumar, T.K., Prudovsky, I., Phosphatidylserine externalization and membrane blebbing are involved in the nonclassical export of FGF1. J Cell Biochem, 113: 956-66, 2012

Awasthi, N., Yen, P.L., Schwarz, M.A., Schwarz, R.E., The efficacy of a novel, dual PI3K/mTOR inhibitor NVP-BEZ235 to enhance chemotherapy and antiangiogenic response in pancreatic cancer. J Cell Biochem, 113: 784-91, 2012

Dasgupta, S., Soudry, E., Mukhopadhyay, N., Shao, C., Yee, J., Lam, S., Lam, W., Zhang, W., Gazdar, A.F., Fisher, P.B., Sidransky, D., Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression and associated with EGFR gene mutation. Journal of cellular physiology, 227: 2451-60, 2012

Sunaga, N., Imai, H., Shimizu, K., Shames, D.S., Kakegawa, S., Girard, L., Sato, M., Kaira, K., Ishizuka, T., Gazdar, A.F., Minna, J.D., Mori, M., Oncogenic KRAS-induced interleukin-8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non-small cell lung cancer. International journal of cancer. Journal international du cancer, 130: 1733-44, 2012

Carbone, M., Ly, B.H., Dodson, R.F., Pagano, I., Morris, P.T., Dogan, U.A., Gazdar, A.F., Pass, H.I., Yang, H., Malignant mesothelioma: facts, myths, and hypotheses. J Cell Physiol, 227: 44-58, 2012

2011

Zhao, D, Stafford, JH, Zhou, H, Thorpe, PE: Near-infrared Optical Imaging of Exposed Phosphatidylserine in a Mouse Glioma Model. Transl Oncol 4:355-64, 2011

Dellinger, MT, Brekken, RA: Phosphorylation of Akt and ERK1/2 is required for VEGF-A/VEGFR2-induced proliferation and migration of lymphatic endothelium. PLoS One 6:e28947, 2011

Gazdar, AF, Schiller, JH: Predictive and Prognostic Factors for Non-Small Cell Lung Cancer--Potholes in the Road to the Promised Land. J Natl Cancer Inst, 2011

Larsen, JE, Cascone, T, Gerber, DE, Heymach, JV, Minna, JD: Targeted therapies for lung cancer: clinical experience and novel agents. Cancer J 17:512-27, 2011

Gazdar, AF, Zhang, YA: Research highlights. Epigenomics 3:405-7, 2011

Gazdar, AF, Brambilla, E: Preneoplasia of lung cancer. Cancer Biomark 9:385-96, 2011

Horio, M, Sato, M, Takeyama, Y, Elshazley, M, Yamashita, R, Hase, T, Yoshida, K, Usami, N, Yokoi, K, Sekido, Y, Kondo, M, Toyokuni, S, Gazdar, AF, Minna, JD, Hasegawa, Y: Transient but Not Stable ZEB1 Knockdown Dramatically Inhibits Growth of Malignant Pleural Mesothelioma Cells. Ann Surg Oncol, 2011

Toyooka, S, Gazdar, AF: Methylation profiling of lung cancer: a decade of progress. Mol Cancer Ther 10:2020, 2011

Larsen, JE, Minna, JD: Molecular biology of lung cancer: clinical implications. Clin Chest Med 32:703-40, 2011

Lam, DC, Minna, JD: How do we safely get people to stop smoking? Cancer Prev Res (Phila) 4:1724-7, 2011

Greer, RM, Peyton, M, Larsen, JE, Girard, L, Xie, Y, Gazdar, AF, Harran, P, Wang, L, Brekken, RA, Wang, X, Minna, JD: SMAC mimetic (JP1201) sensitizes non-small cell lung cancers to multiple chemotherapy agents in an IAP-dependent but TNF-alpha-independent manner. Cancer Res 71:7640-8, 2011

Gerber, DE, Stopeck, AT, Wong, L, Rosen, LS, Thorpe, PE, Shan, JS, Ibrahim, NK: Phase I safety and pharmacokinetic study of bavituximab, a chimeric phosphatidylserine-targeting monoclonal antibody, in patients with advanced solid tumors. Clin Cancer Res 17:6888-96, 2011

Starczynowski, DT, Lockwood, WW, Delehouzee, S, Chari, R, Wegrzyn, J, Fuller, M, Tsao, MS, Lam, S, Gazdar, AF, Lam, WL, Karsan, A: TRAF6 is an amplified oncogene bridging the RAS and NF-kappaB pathways in human lung cancer. J Clin Invest, 2011

Taguchi, A, Politi, K, Pitteri, SJ, Lockwood, WW, Faca, VM, Kelly-Spratt, K, Wong, CH, Zhang, Q, Chin, A, Park, KS, Goodman, G, Gazdar, AF, Sage, J, Dinulescu, DM, Kucherlapati, R, Depinho, RA, Kemp, CJ, Varmus, HE, Hanash, SM: Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell 20:289-99, 2011

Shay, JW, Cucinotta, FA, Sulzman, FM, Coleman, CN, Minna, JD: From mice and men to earth and space: joint NASA-NCI workshop on lung cancer risk resulting from space and terrestrial radiation. Cancer Res 71:6926-9, 2011

Nomura, M, Fukuda, T, Fujii, K, Kawamura, T, Tojo, H, Kihara, M, Bando, Y, Gazdar, AF, Tsuboi, M, Oshiro, H, Nagao, T, Ohira, T, Ikeda, N, Gotoh, N, Kato, H, Marko-Varga, G, Nishimura, T: Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study. J Clin Bioinforma 1:23, 2011

Girotti, MR, Fernandez, M, Lopez, JA, Camafeita, E, Fernandez, EA, Albar, JP, Benedetti, LG, Valacco, MP, Brekken, RA, Podhajcer, OL, Llera, AS: SPARC promotes cathepsin B-mediated melanoma invasiveness through a collagen I/alpha2beta1 integrin axis. J Invest Dermatol 131:2438-47, 2011

Awasthi, N, Schwarz, MA, Schwarz, RE: Antitumour activity of sunitinib in combination with gemcitabine in experimental pancreatic cancer. HPB (Oxford) 13:597-604, 2011

DeRose, P, Thorpe, PE, Gerber, DE: Development of bavituximab, a vascular targeting agent with immune-modulating properties, for lung cancer treatment. Immunotherapy 3:933-44, 2011

Dasgupta, S, Soudry, E, Mukhopadhyay, N, Shao, C, Yee, J, Lam, S, Lam, W, Zhang, W, Gazdar, AF, Fisher, PB, Sidransky, D: Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression and associated with EGFR gene mutation. J Cell Physiol, 2011

Rivera, LB, Bradshaw, AD, Brekken, RA: The regulatory function of SPARC in vascular biology. Cell Mol Life Sci 68:3165-73, 2011

Thu, KL, Pikor, LA, Chari, R, Wilson, IM, Macaulay, CE, English, JC, Tsao, MS, Gazdar, AF, Lam, S, Lam, WL, Lockwood, WW: Genetic Disruption of KEAP1/CUL3 E3 Ubiquitin Ligase Complex Components is a Key Mechanism of NF-KappaB Pathway Activation in Lung Cancer. J Thorac Oncol 6:1521-1529, 2011

Euhus, D, Bu, D, Xie, XJ, Sarode, V, Ashfaq, R, Hunt, K, Xia, W, O'Shaughnessy, J, Grant, M, Arun, B, Dooley, W, Miller, A, Flockhart, D, Lewis, C: Tamoxifen downregulates ets oncogene family members ETV4 and ETV5 in benign breast tissue: implications for durable risk reduction. Cancer Prev Res (Phila) 4:1852-62, 2011

Zhang, YA, Maitra, A, Hsieh, JT, Rudin, CM, Peacock, C, Karikari, C, Brekken, RA, Stastny, V, Gao, B, Girard, L, Wistuba, I, Frenkel, E, Minna, JD, Gazdar, AF: Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts. Cancer Biol Ther 12, 2011

Zhang, YA, Maitra, A, Hsieh, JT, Rudin, CM, Peacock, CD, Karikari, C, Brekken, RA, Stastny, V, Gao, B, Girard, L, Wistuba, I, Frenkel, E, Minna, JD, Gazdar, AF: Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts. Cancer Biol Ther 12:617-28, 2011

Xie, Y, Xiao, G, Coombes, KR, Behrens, C, Solis, LM, Raso, G, Girard, L, Erickson, HS, Roth, J, Heymach, JV, Moran, C, Danenberg, K, Minna, JD, Wistuba, II: Robust gene expression signature from formalin-fixed paraffin-embedded samples predicts prognosis of non-small-cell lung cancer patients. Clin Cancer Res 17:5705-14, 2011

Rivera, LB, Brekken, RA: SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-beta1 activity. J Cell Biol 193:1305-19, 2011

Harris, BS, Zhang, Y, Card, L, Rivera, LB, Brekken, RA, Bradshaw, AD: SPARC regulates collagen interaction with cardiac fibroblast cell surfaces. Am J Physiol Heart Circ Physiol 301:H841-7, 2011

Huang, X, Ye, D, Thorpe, PE: Enhancing the potency of a whole-cell breast cancer vaccine in mice with an antibody-IL-2 immunocytokine that targets exposed phosphatidylserine. Vaccine 29:4785-93, 2011

Hill, VK, Ricketts, C, Bieche, I, Vacher, S, Gentle, D, Lewis, C, Maher, ER, Latif, F: Genome-wide DNA methylation profiling of CpG islands in breast cancer identifies novel genes associated with tumorigenicity. Cancer Res 71:2988-99, 2011

Galindo, CL, McIver, LJ, Tae, H, McCormick, JF, Skinner, MA, Hoeschele, I, Lewis, CM, Minna, JD, Boothman, DA, Garner, HR: Sporadic breast cancer patients' germline DNA exhibit an AT-rich microsatellite signature. Genes Chromosomes Cancer 50:275-83, 2011

Hogg, RT, Thorpe, P, Gerard, RD: Retargeting adenoviral vectors to improve gene transfer into tumors. Cancer Gene Ther 18:275-87, 2011

Ramesh, S, Morrell, CN, Tarango, C, Thomas, GD, Yuhanna, IS, Girardi, G, Herz, J, Urbanus, RT, de Groot, PG, Thorpe, PE, Salmon, JE, Shaul, PW, Mineo, C: Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via beta2GPI and apoER2. J Clin Invest 121:120-31, 2011

Awasthi, N, Schwarz, MA, Schwarz, RE: Enhancing cytotoxic agent activity in experimental pancreatic cancer through EMAP II combination therapy. Cancer Chemother Pharmacol 68:571-82, 2011

Vasalatiy, O, Zhao, P, Woods, M, Marconescu, A, Castillo-Muzquiz, A, Thorpe, P, Kiefer, GE, Sherry, AD: Strategies for labeling proteins with PARACEST agents. Bioorg Med Chem 19:1106-14, 2011

Liang, Y, Besch-Williford, C, Benakanakere, I, Thorpe, PE, Hyder, SM: Targeting mutant p53 protein and the tumor vasculature: an effective combination therapy for advanced breast tumors. Breast Cancer Res Treat 125:407-20, 2011

Sunaga N, Imai H, Shimizu K, Shames DS, Kakegawa S, Girard L, Sato M, Kaira K, Ishizuka T, Gazdar AF, Minna JD, Mori M: Oncogenic KRAS-induced interleukin-8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non-small cell lung cancer. International Journal of Cancer, 2011

Hase T, Sato M, Yoshida K, Girard L, Takeyama Y, Horio M, Elshazley M, Oguri T, Sekido Y, Shames DS, Gazdar AF, Minna JD, Kondo M, Hasegawa Y: A Pivotal Role for Epithelial Cell Adhesion Molecule (EpCAM) in the Survival of Lung Cancer Cells. Cancer Science, 2011

Gazdar AF: Tyrosine Kinase Inhibitors and Epidermal Growth Factor Receptor (EGFR) Mutations in Non-Small Cell Lung Cancer: To Test or Not to Test? Medicine (Baltimore) 90:168-70, 2011

Sierko E, Wojtukiewicz MZ, Zimnoch L, Thorpe PE, Brekken RA, Kisiel W: Co-localization of Prothrombin Fragment F1+2 and VEGF-R2-Bound VEGF in Human Colon Cancer. Anticancer Research 31:843-7, 2011

Stafford JH, Thorpe PE: Increased exposure of phosphatidylethanolamine on the surface of tumor vascular endothelium. Neoplasia 13:299-308, 2011

Carbone M, Ly BH, Dodson RF, Pagano I, Morris PT, Dogan UA, Gazdar AF, Pass HI, Yang H:Malignant mesothelioma: Facts, myths and hypotheses. Journal of Cellular Physiology, 2011

Euhus DM: New insights into the prevention and treatment of familial breast cancer. Journal of Surgical Oncology 103:294-8, 2011

Ou YH, Torres M, Ram R, Formstecher E, Roland C, Cheng T, Brekken R, Wurz R, Tasker A, Polverino T, Tan SL, White MA: TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation. Molecular Cell 41:458-70, 2011

Sunaga N, Shames DS, Girard L, Peyton M, Larsen JE, Imai H, Soh J, Sato M, Yanagitani N, Kaira K, Xie Y, Gazdar AF, Mori M, Minna JD: Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy. Molecular Cancer Theraputics 10:336-46, 2011

Schwarz RE: Challenges with demographic disparities in gastric cancer care and survival: spectral rather than black and white. Cancer Epidemiology Biomarkers and Prevention 20:221-2, 2011

Tang X, Kadara H, Behrens C, Liu D, Xiao Y, Rice DC, Gazdar AF, Fujimoto J, Moran C, Varella-Garcia M, Lee JJ, Hong WK, Wistuba, II: Abnormalities of the TITF-1 lineage-specific oncogene in NSCLC: Implications in lung cancer pathogenesis and prognosis. Clinical Cancer Research, 2011

Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D:International association for the study of lung cancer/american thoracic society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. Journal of Thoracic Oncology 6:244-85, 2011

Best AM, Chang J, Dull AB, Beutler JA, Martinez ED: Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell-based assay. Journal of Biomedicine and Biotechnology:868095, 2011

Awasthi N, Kirane A, Schwarz MA, Toombs JE, Brekken RA, Schwarz RE: Smac mimetic-derived augmentation of chemotherapeutic response in experimental pancreatic cancer. Biomed Central 11:15, 2011

Li LS, Bey EA, Dong Y, Meng J, Patra B, Yan J, Xie XJ, Brekken RA, Barnett CC, Bornmann WG, Gao J, Boothman DA: Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of beta-lapachone for pancreatic cancer therapy. Clinical Cancer Research 17:275-85, 2011

Chandra M, Zhou H, Li Q, Muallem S, Hofmann SL, Soyombo AA: A role for the Ca2+ channel TRPML1 in gastric acid secretion, based on analysis of knockout mice. Gastroenterology 140:857-67, 2011

Rule W, Timmerman R, Tong L, Abdulrahman R, Meyer J, Boike T, Schwarz RE, Weatherall P, Chinsoo Cho L: Phase I dose-escalation study of stereotactic body radiotherapy in patients with hepatic metastases. Annals of Surgical Oncology 18:1081-7, 2011

Mansour JC, Schwarz RE: Resection of type I gastric carcinoid: when and why? Journal of Surgical Research 166:68-9, 2011

Yamaguchi S, Jha A, Li Q, Soyombo AA, Dickinson GD, Churamani D, Brailoiu E, Patel S, Muallem S: TRPML1 and the two-pore channels are functionally independent organellar ion channels. Journal of Biological Chemistry, 2011

Back to Top

2010

Tokuyama Y, Takahashi T, Okumura N, Nonaka K, Kawaguchi Y, Yamaguchi K, Osada S, Gazdar A, Yoshida K: Aberrant methylation of heparan sulfate glucosamine 3-O-sulfotransferase 2 genes as a biomarker in colorectal cancer. Anticancer Research 30:4811-8, 2010

Jeong Y, Xie Y, Xiao G, Behrens C, Girard L, Wistuba, II, Minna JD, Mangelsdorf DJ: Nuclear receptor expression defines a set of prognostic biomarkers for lung cancer. PLoS Medicine 7:e1000378, 2010

Gerber DE, Minna JD: ALK inhibition for non-small cell lung cancer: from discovery to therapy in record time. Cancer Cell 18:548-51, 2010

Sullivan JP, Spinola M, Dodge M, Raso MG, Behrens C, Gao B, Schuster K, Shao C, Larsen JE, Sullivan LA, Honorio S, Xie Y, Scaglioni PP, DiMaio JM, Gazdar AF, Shay JW, Wistuba, II, Minna JD: Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Research 70:9937-48, 2010

Chandra M, Zhou H, Li Q, Muallem S, Hofmann SL, Soyombo AA: A Role for the Ca(2+) Channel TRPML1 in Gastric Acid Secretion, Based on Analysis of Knockout Mice. Gastroenterology, 2010

Awasthi N, Schwarz MA, Schwarz RE: Enhancing cytotoxic agent activity in experimental pancreatic cancer through EMAP II combination therapy. Cancer Chemotherapy and Pharmacology, 2010

Ramos AL, Darabi R, Akbarloo N, Borges L, Catanese J, Dineen SP, Brekken RA, Perlingeiro RC: Clonal analysis reveals a common progenitor for endothelial, myeloid, and lymphoid precursors in umbilical cord blood. Circulation Research 107:1460-9, 2010

Gazdar AF: Should we continue to use the term non-small-cell lung cancer? Annals of Oncology 21 Suppl 7:vii225-vii229, 2010

Xie Y, Minna JD: Non-small-cell lung cancer mRNA expression signature predicting response to adjuvant chemotherapy. Journal of Clinical Oncology 28:4404-7, 2010

De Leon-Rodriguez LM, Lubag A, Udugamasooriya DG, Proneth B, Brekken RA, Sun X, Kodadek T, Dean Sherry A: MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting. Journal of the American Chemical Society 132:12829-31, 2010

Sullivan LA, Carbon JG, Roland CL, Toombs JE, Nyquist-Andersen M, Kavlie A, Schlunegger K, Richardson JA, Brekken RA: r84, a novel therapeutic antibody against mouse and human VEGF with potent anti-tumor activity and limited toxicity induction. PLoS One 5:e12031, 2010

Das AK, Bell MH, Nirodi CS, Story MD, Minna JD: Radiogenomics predicting tumor responses to radiotherapy in lung cancer. Seminars in Radiation Oncology 20:149-55, 2010

Saha D, Watkins L, Yin Y, Thorpe P, Story MD, Song K, Raghavan P, Timmerman R, Chen B, Minna JD, Solberg TD: An orthotopic lung tumor model for image-guided microirradiation in rats. Radiation Research 174:62-71, 2010

Gazdar AF, Girard L, Lockwood WW, Lam WL, Minna JD: Lung cancer cell lines as tools for biomedical discovery and research. Journal of the National Cancer Institute 102:1310-21, 2010

Lynn KD, Udugamasooriya DG, Roland CL, Castrillon DH, Kodadek TJ, Brekken RA: GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer. Biomed Central 10:397, 2010

Lockwood WW, Chari R, Coe BP, Thu KL, Garnis C, Malloff CA, Campbell J, Williams AC, Hwang D, Zhu CQ, Buys TP, Yee J, English JC, Macaulay C, Tsao MS, Gazdar AF, Minna JD, Lam S, Lam WL: Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma. PLoS Medicine 7:e1000315, 2010

Cai D, Shames DS, Raso MG, Xie Y, Kim YH, Pollack JR, Girard L, Sullivan JP, Gao B, Peyton M, Nanjundan M, Byers L, Heymach J, Mills G, Gazdar AF, Wistuba I, Kodadek T, Minna JD:Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation. Cancer Research 70:6477-85, 2010

Korpanty G, Sullivan LA, Smyth E, Carney DN, Brekken RA: Molecular and clinical aspects of targeting the VEGF pathway in tumors. Journal of Oncology 2010:652320, 2010

Du L, Schageman JJ, Irnov, Girard L, Hammond SM, Minna JD, Gazdar AF, Pertsemlidis A:MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs. Journal of Experimental and Clinical Cancer Research 29:75, 2010

Sullivan JP, Minna JD: Tumor oncogenotypes and lung cancer stem cell identity. Cell Stem Cell 7:2-4, 2010

Villasenor A, Wang ZV, Rivera LB, Ocal O, Asterholm IW, Scherer PE, Brekken RA, Cleaver O, Wilkie TM: Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes. Disease Models and Mechanisms 3:567-80, 2010

Schwarz RE, Abou-Alfa GK, Geschwind JF, Krishnan S, Salem R, Venook AP: Nonoperative therapies for combined modality treatment of hepatocellular cancer: expert consensus statement. HPB (Oxford) 12:313-20, 2010

Dixon E, Abdalla E, Schwarz RE, Vauthey JN: AHPBA/SSO/SSAT sponsored Consensus Conference on Multidisciplinary Treatment of Hepatocellular Carcinoma. HPB (Oxford) 12:287-8, 2010

Chambliss KL, Wu Q, Oltmann S, Konaniah ES, Umetani M, Korach KS, Thomas GD, Mineo C, Yuhanna IS, Kim SH, Madak-Erdogan Z, Maggi A, Dineen SP, Roland CL, Hui DY, Brekken RA, Katzenellenbogen JA, Katzenellenbogen BS, Shaul PW: Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice. Journal of Clinical Investigation 120:2319-30, 2010

Barnett CC, Jr., Beck AW, Holloway SE, Kehler M, Schluterman MK, Brekken RA, Fleming JB, Silliman CC: Intravenous delivery of the plasma fraction of stored packed erythrocytes promotes pancreatic cancer growth in immunocompetent mice. Cancer 116:3862-74, 2010

Gazdar AF, Boffetta P: A risky business--identifying susceptibility loci for lung cancer. Journal of the National Cancer Institute 102:920-3, 2010

Awasthi N, Schwarz MA, Schwarz RE: Combination effects of bortezomib with gemcitabine and EMAP II in experimental pancreatic cancer. Cancer Biology and Therapy 10:99-107, 2010

Sanders DN, Farias FH, Johnson GS, Chiang V, Cook JR, O'Brien DP, Hofmann SL, Lu JY, Katz ML: A mutation in canine PPT1 causes early onset neuronal ceroid lipofuscinosis in a Dachshund. Molecular Genetics and Metabolism 100:349-56, 2010

Benedettini E, Sholl LM, Peyton M, Reilly J, Ware C, Davis L, Vena N, Bailey D, Yeap BY, Fiorentino M, Ligon AH, Pan BS, Richon V, Minna JD, Gazdar AF, Draetta G, Bosari S, Chirieac LR, Lutterbach B, Loda M: Met Activation in Non-Small Cell Lung Cancer Is Associated with de Novo Resistance to EGFR Inhibitors and the Development of Brain Metastasis. American Journal of Pathology, 2010

Takeyama Y, Sato M, Horio M, Hase T, Yoshida K, Yokoyama T, Nakashima H, Hashimoto N, Sekido Y, Gazdar AF, Minna JD, Kondo M, Hasegawa Y: Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells. Cancer Letters, 2010

Roland CL, Dineen SP, Toombs JE, Carbon JG, Smith CW, Brekken RA, Barnett CC, Jr.:Tumor-derived intercellular adhesion molecule-1 mediates tumor-associated leukocyte infiltration in orthotopic pancreatic xenografts. Experimental Biology and Medicine (Maywood) 235:263-70, 2010

Korpanty G, Smyth E, Sullivan LA, Brekken RA, Carney DN: Antiangiogenic therapy in lung cancer: focus on vascular endothelial growth factor pathway. Experimental Biology and Medicine (Maywood) 235:3-9, 2010

Hohenstein B, Colin M, Foellmer C, Amann KU, Brekken RA, Daniel C, Hugo CP: Autocrine VEGF-VEGF-R loop on podocytes during glomerulonephritis in humans. Nephrology Dialysis Transplantation 25:3170-80, 2010

Liu P, Yang P, Wu X, Vikis HG, Lu Y, Wang Y, Schwartz AG, Pinney SM, de Andrade M, Gazdar A, Gaba C, Mandal D, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Spitz M, Amos CI, Anderson MW, You M: A second genetic variant on chromosome 15q24-25.1 associates with lung cancer. Cancer Research 70:3128-35, 2010

Holbeck S, Chang J, Best AM, Bookout AL, Mangelsdorf DJ, Martinez ED: Expression profiling of nuclear receptors in the NCI60 cancer cell panel reveals receptor-drug and receptor-gene interactions. Molecular Endocrinology 24:1287-96, 2010

Bo LE, Gjerald SU, Brekken R, Tangen GA, Hernes TA: Efficiency of ultrasound training simulators: method for assessing image realism. Minimally Invasive Therapy and Allied Technologies 19:69-74, 2010

Dineen SP, Roland CL, Greer R, Carbon JG, Toombs JE, Gupta P, Bardeesy N, Sun H, Williams N, Minna JD, Brekken RA: Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer. Cancer Research 70:2852-61, 2010

Spinola M, Falvella FS, Colombo F, Sullivan JP, Shames DS, Girard L, Spessotto P, Minna JD, Dragani TA: MFSD2A is a novel lung tumor suppressor gene modulating cell cycle and matrix attachment. Molecular Cancer 9:62, 2010

Amos CI, Pinney SM, Li Y, Kupert E, Lee J, de Andrade MA, Yang P, Schwartz AG, Fain PR, Gazdar A, Minna J, Wiest JS, Zeng D, Rothschild H, Mandal D, You M, Coons T, Gaba C, Bailey-Wilson JE, Anderson MW: A susceptibility locus on chromosome 6q greatly increases lung cancer risk among light and never smokers. Cancer Research 70:2359-67, 2010

Schwarz RE, Awasthi N, Konduri S, Caldwell L, Cafasso D, Schwarz MA: Antitumor effects of EMAP II against pancreatic cancer through inhibition of fibronectin-dependent proliferation. Cancer Biology and Therapy 9:632-9, 2010

Hill VK, Hesson LB, Dansranjavin T, Dallol A, Bieche I, Vacher S, Tommasi S, Dobbins T, Gentle D, Euhus D, Lewis C, Dammann R, Ward RL, Minna J, Maher ER, Pfeifer GP, Latif F:Identification of 5 novel genes methylated in breast and other epithelial cancers. Molecular Cancer 9:51, 2010

Schluterman MK, Chapman SL, Korpanty G, Ozumi K, Fukai T, Yanagisawa H, Brekken RA:Loss of fibulin-5 binding to beta1 integrins inhibits tumor growth by increasing the level of ROS. Disease Models and Mechanisms 3:333-42, 2010

Shivapurkar N, Gazdar AF: DNA Methylation Based Biomarkers in Non-Invasive Cancer Screening. Current Molecular Medicine, 2010

Sullivan LA, Brekken RA: The VEGF family in cancer and antibody-based strategies for their inhibition. MAbs 2, 2010

Li Y, Hu J, Hofer K, Wong AM, Cooper JD, Birnbaum SG, Hammer RE, Hofmann SL: DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory. Journal of Biological Chemistry 285:13022-31, 2010

Xu L, Nilsson MB, Saintigny P, Cascone T, Herynk MH, Du Z, Nikolinakos PG, Yang Y, Prudkin L, Liu D, Lee JJ, Johnson FM, Wong KK, Girard L, Gazdar AF, Minna JD, Kurie JM, Wistuba, II, Heymach JV: Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1alpha in non-small cell lung cancer cells. Oncogene, 2010

Liu P, Vikis HG, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Gazdar A, Gaba C, Mandal D, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW, You M: Cumulative effect of multiple Loci on genetic susceptibility to familial lung cancer. Cancer Epidemiology Biomarkers and Prevention 19:517-24, 2010

Gazdar AF: Epidermal growth factor receptor inhibition in lung cancer: the evolving role of individualized therapy. Cancer and Metastasis Review, 2010

Ishizumi T, McWilliams A, Macaulay C, Gazdar A, Lam S: Natural history of bronchial preinvasive lesions. Cancer and Metastasis Review, 2010

Chari R, Thu KL, Wilson IM, Lockwood WW, Lonergan KM, Coe BP, Malloff CA, Gazdar AF, Lam S, Garnis C, Macaulay CE, Alvarez CE, Lam WL: Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer. Cancer and Metastasis Review, 2010

Gazdar AF: Preface. Cancer and Metastasis Review, 2010

Sullivan JP, Minna JD, Shay JW: Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy. Cancer and Metastasis Review 29:61-72, 2010

Gazdar AF, Gao B, Minna JD: Lung cancer cell lines: Useless artifacts or invaluable tools for medical science? Lung Cancer 68:309-18, 2010

Alberts SR, Roh MS, Mahoney MR, O'Connell MJ, Nagorney DM, Wagman L, Smyrk TC, Weiland TL, Lai LL, Schwarz RE, Molina R, Dentchev T, Bolton JS: Alternating systemic and hepatic artery infusion therapy for resected liver metastases from colorectal cancer: a North Central Cancer Treatment Group (NCCTG)/ National Surgical Adjuvant Breast and Bowel Project (NSABP) phase II intergroup trial, N9945/CI-66. Journal of Clinical Oncology 28:853-8, 2010

Schwarz RE, Awasthi N, Konduri S, Cafasso D, Schwarz MA: EMAP II-based antiangiogenic-antiendothelial in vivo combination therapy of pancreatic cancer. Annals of Surgical Oncology 17:1442-52, 2010

Lu JY, Hu J, Hofmann SL: Human recombinant palmitoyl-protein thioesterase-1 (PPT1) for preclinical evaluation of enzyme replacement therapy for infantile neuronal ceroid lipofuscinosis. Molecular Genetics and Metabolism 99:374-378, 2010

Pleasance ED, Stephens PJ, O'Meara S, McBride DJ, Meynert A, Jones D, Lin ML, Beare D, Lau KW, Greenman C, Varela I, Nik-Zainal S, Davies HR, Ordonez GR, Mudie LJ, Latimer C, Edkins S, Stebbings L, Chen L, Jia M, Leroy C, Marshall J, Menzies A, Butler A, Teague JW, Mangion J, Sun YA, McLaughlin SF, Peckham HE, Tsung EF, Costa GL, Lee CC, Minna JD, Gazdar A, Birney E, Rhodes MD, McKernan KJ, Stratton MR, Futreal PA, Campbell PJ: A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature 463:184-90, 2010

Arnold SA, Rivera LB, Miller AF, Carbon JG, Dineen SP, Xie Y, Castrillon DH, Sage EH, Puolakkainen P, Bradshaw AD, Brekken RA: Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma. Disease Models and Mechanisms 3:57-72, 2010

Kim YH, Kwei KA, Girard L, Salari K, Kao J, Pacyna-Gengelbach M, Wang P, Hernandez-Boussard T, Gazdar AF, Petersen I, Minna JD, Pollack JR: Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer. Oncogene 29:1421-30, 2010

Back to Top
 

2009

Awasthi N, Schwarz MA, Schwarz RE: Proteasome inhibition enhances antitumour effects of gemcitabine in experimental pancreatic cancer. HPB (Oxford) 11:600-5, 2009

Kim YH, Kwei KA, Girard L, Salari K, Kao J, Pacyna-Gengelbach M, Wang P, Hernandez-Boussard T, Gazdar AF, Petersen I, Minna JD, Pollack JR: Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer. Oncogene, 2009

Roland CL, Lynn KD, Toombs JE, Dineen SP, Udugamasooriya DG, Brekken RA: Cytokine levels correlate with immune cell infiltration after anti-VEGF therapy in preclinical mouse models of breast cancer. PLoS One 4:e7669, 2009

He J, Yin Y, Luster TA, Watkins L, Thorpe PE: Antiphosphatidylserine antibody combined with irradiation damages tumor blood vessels and induces tumor immunity in a rat model of glioblastoma. Clinical Cancer Research 15:6871-80, 2009

Rudin C, Minna J: Cancer stem cells. Journal of Thoracic Oncology 4:S1079-81, 2009

Soh J, Okumura N, Lockwood WW, Yamamoto H, Shigematsu H, Zhang W, Chari R, Shames DS, Tang X, MacAulay C, Varella-Garcia M, Vooder T, Wistuba, II, Lam S, Brekken R, Toyooka S, Minna JD, Lam WL, Gazdar AF: Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells. PLoS One 4:e7464, 2009

Arnold SA, Brekken RA: SPARC: a matricellular regulator of tumorigenesis. Journal of Cell Communication and Signaling 3:255-73, 2009

Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, O'Kelly M, Dutt A, Rozenblatt-Rosen O, Dziunycz P, Komisarof J, Chirieac LR, Lafargue CJ, Scheble V, Wilbertz T, Ma C, Rao S, Nakagawa H, Stairs DB, Lin L, Giordano TJ, Wagner P, Minna JD, Gazdar AF, Zhu CQ, Brose MS, Cecconello I, Jr UR, Marie SK, Dahl O, Shivdasani RA, Tsao MS, Rubin MA, Wong KK, Regev A, Hahn WC, Beer DG, Rustgi AK, Meyerson M: SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nature Genetics 41:1238-42, 2009

Yanagisawa H, Schluterman MK, Brekken RA: Fibulin-5, an integrin-binding matricellular protein: its function in development and disease. Journal of Cell Communication and Signaling 3:337-47, 2009

Konstantinidou G, Bey EA, Rabellino A, Schuster K, Maira MS, Gazdar AF, Amici A, Boothman DA, Scaglioni PP: Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations. Cancer Research 69:7644-52, 2009

Liu Y, Liu P, Wen W, James MA, Wang Y, Bailey-Wilson JE, Amos CI, Pinney SM, Yang P, de Andrade M, Petersen GM, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Lee J, Seminara D, Minna J, Anderson MW, You M: Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1. Cancer Research 69:7844-50, 2009

Gazdar AF: Personalized medicine and inhibition of EGFR signaling in lung cancer. New England Journal of medicine 361:1018-20, 2009

Gazdar AF: Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors. Oncogene 28 Suppl 1:S24-31, 2009

Albuquerque RJ, Hayashi T, Cho WG, Kleinman ME, Dridi S, Takeda A, Baffi JZ, Yamada K, Kaneko H, Green MG, Chappell J, Wilting J, Weich HA, Yamagami S, Amano S, Mizuki N, Alexander JS, Peterson ML, Brekken RA, Hirashima M, Capoor S, Usui T, Ambati BK, Ambati J:Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. Nature Medicine 15:1023-30, 2009

Chen TT, Rakheja D, Hung JY, Hornsby PJ, Tabaczewski P, Malogolowkin M, Feusner J, Miskevich F, Schultz R, Tomlinson GE: Establishment and characterization of a cancer cell line derived from an aggressive childhood liver tumor. Pediatric Blood and Cancer 53:1040-7, 2009

Lee P, van den Berg RM, Lam S, Gazdar AF, Grunberg K, McWilliams A, Leriche J, Postmus PE, Sutedja TG: Color fluorescence ratio for detection of bronchial dysplasia and carcinoma in situ. Clinical Cancer Research 15:4700-5, 2009

Kao J, Salari K, Bocanegra M, Choi YL, Girard L, Gandhi J, Kwei KA, Hernandez-Boussard T, Wang P, Gazdar AF, Minna JD, Pollack JR: Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery. PLoS One 4:e6146, 2009

Roland CL, Dineen SP, Lynn KD, Sullivan LA, Dellinger MT, Sadegh L, Sullivan JP, Shames DS, Brekken RA: Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts. Molecular Cancer Theraputics 8:1761-71, 2009

Halberg N, Khan T, Trujillo ME, Wernstedt-Asterholm I, Attie AD, Sherwani S, Wang ZV, Landskroner-Eiger S, Dineen S, Magalang UJ, Brekken RA, Scherer PE: Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Molecular and Cellular Biology 29:4467-83, 2009

Kim HJ, Soyombo AA, Tjon-Kon-Sang S, So I, Muallem S: The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy. Traffic 10:1157-67, 2009

Matsuo Y, Campbell PM, Brekken RA, Sung B, Ouellette MM, Fleming JB, Aggarwal BB, Der CJ, Guha S: K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways. Molecular CancerResearch7:799-808, 2009

Brambilla E, Gazdar A: Pathogenesis of lung cancer signalling pathways: roadmap for therapies. European Respiratory Journal 33:1485-97, 2009

Sos ML, Michel K, Zander T, Weiss J, Frommolt P, Peifer M, Li D, Ullrich R, Koker M, Fischer F, Shimamura T, Rauh D, Mermel C, Fischer S, Stuckrath I, Heynck S, Beroukhim R, Lin W, Winckler W, Shah K, Laframboise T, Moriarty WF, Hanna M, Tolosi L, Rahnenfuhrer J, Verhaak R, Chiang D, Getz G, Hellmich M, Wolf J, Girard L, Peyton M, Weir BA, Chen TH, Greulich H, Barretina J, Shapiro GI, Garraway LA, Gazdar AF, Minna JD, Meyerson M, Wong KK, Thomas RK: Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions. Journal of Clinical Investigation, 2009

Arguello AA, Fischer SJ, Schonborn JR, Markus RW, Brekken RA, Eisch AJ: Effect of chronic morphine on the dentate gyrus neurogenic microenvironment. Neuroscience 159:1003-10, 2009

Gazdar AF, Minna JD: Multifocal lung cancers-clonality vs field cancerization and does it matter? Journal of the National Cancer Institute 101:541-3, 2009

Sos ML, Koker M, Weir BA, Heynck S, Rabinovsky R, Zander T, Seeger JM, Weiss J, Fischer F, Frommolt P, Michel K, Peifer M, Mermel C, Girard L, Peyton M, Gazdar AF, Minna JD, Garraway LA, Kashkar H, Pao W, Meyerson M, Thomas RK: PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR. Cancer Research 69:3256-61, 2009

You M, Wang D, Liu P, Vikis H, James M, Lu Y, Wang Y, Wang M, Chen Q, Jia D, Liu Y, Wen W, Yang P, Sun Z, Pinney SM, Zheng W, Shu XO, Long J, Gao YT, Xiang YB, Chow WH, Rothman N, Petersen GM, de Andrade M, Wu Y, Cunningham JM, Wiest JS, Fain PR, Schwartz AG, Girard L, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW: Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. Clinical Cancer Research 15:2666-74, 2009

Mansour JC, Schwarz RE: Pathologic response to preoperative therapy: does it mean what we think it means? Annals of Surgical Oncology 16:1465-79, 2009

Gandhi J, Zhang J, Xie Y, Soh J, Shigematsu H, Zhang W, Yamamoto H, Peyton M, Girard L, Lockwood WW, Lam WL, Varella-Garcia M, Minna JD, Gazdar AF: Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. PLoS One 4:e4576, 2009

Miura N, Sato R, Tsukamoto T, Shimizu M, Kabashima H, Takeda M, Takahashi S, Harada T, West JE, Drabkin H, Mejia JE, Shiota G, Murawaki Y, Virmani A, Gazdar AF, Oshimura M, Hasegawa J: A noncoding RNA gene on chromosome 10p15.3 may function upstream of hTERT. BMC Molecular Biology 10:5, 2009

Zhang W, Peyton M, Xie Y, Soh J, Minna JD, Gazdar AF, Frenkel EP: Histone deacetylase inhibitor romidepsin enhances anti-tumor effect of erlotinib in non-small cell lung cancer (NSCLC) cell lines. Journal of Thoracic Oncology 4:161-6, 2009

Kubo T, Yamamoto H, Lockwood WW, Valencia I, Soh J, Peyton M, Jida M, Otani H, Fujii T, Ouchida M, Takigawa N, Kiura K, Shimizu K, Date H, Minna JD, Varella-Garcia M, Lam WL, Gazdar AF, Toyooka S: MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors. International Journal of Cancer 124:1778-84, 2009

Edell E, Lam S, Pass H, Miller YE, Sutedja T, Kennedy T, Loewen G, Keith RL, Gazdar A:Detection and localization of intraepithelial neoplasia and invasive carcinoma using fluorescence-reflectance bronchoscopy: an international, multicenter clinical trial. Journal of Thoracic Oncology 4:49-54, 2009

Awasthi N, Schwarz MA, Verma V, Cappiello C, Schwarz RE: Endothelial monocyte activating polypeptide II interferes with VEGF-induced proangiogenic signaling. Laboratory Investigation 89:38-46, 2009

Bull Phelps SL, Carbon J, Miller A, Castro-Rivera E, Arnold S, Brekken RA, Lea JS: Secreted protein acidic and rich in cysteine as a regulator of murine ovarian cancer growth and chemosensitivity. American Journal of Obstetrics and Gynecology 200:180 e1-7, 2009

Vazquez M, Carter D, Brambilla E, Gazdar A, Noguchi M, Travis WD, Huang Y, Zhang L, Yip R, Yankelevitz DF, Henschke CI, International Early Lung Cancer Action Program I: Solitary and multiple resected adenocarcinomas after CT screening for lung cancer: histopathologic features and their prognostic implications. Lung Cancer 64:148-54, 2009

Dineen SP, Roland CL, Toombs JE, Kelher M, Silliman CC, Brekken RA, Barnett CC, Jr.: The acellular fraction of stored platelets promotes tumor cell invasion. Journal of Surgical Research 153:132-7, 2009

Back to Top