Publications
2012
Rudin, CM, Durinck, S, Stawiski, EW, Poirier, JT, Modrusan, Z, Shames, DS, Bergbower, EA, Guan, Y, Shin, J, Guillory, J, Rivers, CS, Foo, CK, Bhatt, D, Stinson, J, Gnad, F, Haverty, PM, Gentleman, R, Chaudhuri, S, Janakiraman, V, Jaiswal, BS, Parikh, C, Yuan, W, Zhang, Z, Koeppen, H, Wu, TD, Stern, HM, Yauch, RL, Huffman, KE, Paskulin, DD, Illei, PB, Varella-Garcia, M, Gazdar, AF, de Sauvage, FJ, Bourgon, R, Minna, JD, Brock, MV, Seshagiri, S: Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nat Genet, 2012
Gerber, DE, Gupta, P, Dellinger, MT, Toombs, JE, Peyton, M, Duignan, I, Malaby, J, Bailey, T, Burns, C, Brekken, RA, Loizos, N: Stromal platelet-derived growth factor receptor alpha (PDGFRalpha) provides a therapeutic target independent of tumor cell PDGFRalpha expression in lung cancer xenografts. Mol Cancer Ther, 2012
Sharma, V, Shivalingaiah, S, Peng, Y, Euhus, D, Gryczynski, Z, Liu, H: Auto-fluorescence lifetime and light reflectance spectroscopy for breast cancer diagnosis: potential tools for intraoperative margin detection. Biomed Opt Express 3:1825-40, 2012
Kirane, A, Toombs, JE, Ostapoff, K, Carbon, JG, Zaknoen, S, Braunfeld, J, Schwarz, RE, Burrows, FJ, Brekken, RA: Apricoxib, a Novel Inhibitor of COX-2, Markedly Improves Standard Therapy Response in Molecularly Defined Models of Pancreatic Cancer. Clin Cancer Res 18:5031-42, 2012
Thunnissen, E, Beasley, MB, Borczuk, AC, Brambilla, E, Chirieac, LR, Dacic, S, Flieder, D, Gazdar, A, Geisinger, K, Hasleton, P, Ishikawa, Y, Kerr, KM, Lantejoul, S, Matsuno, Y, Minami, Y, Moreira, AL, Motoi, N, Nicholson, AG, Noguchi, M, Nonaka, D, Pelosi, G, Petersen, I, Rekhtman, N, Roggli, V, Travis, WD, Tsao, MS, Wistuba, I, Xu, H, Yatabe, Y, Zakowski, M, Witte, B, Kuik, DJ: Reproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma. An international interobserver study. Mod Pathol, 2012
Hezel, AF, Deshpande, V, Zimmerman, SM, Contino, G, Alagesan, B, O'Dell, MR, Rivera, LB, Harper, J, Lonning, S, Brekken, RA, Bardeesy, N: TGF-beta and alphavbeta6 Integrin Act in a Common Pathway to Suppress Pancreatic Cancer Progression. Cancer Res 72:4840-5, 2012
Du, L, Subauste, MC, DeSevo, C, Zhao, Z, Baker, M, Borkowski, R, Schageman, JJ, Greer, R, Yang, CR, Suraokar, M, Wistuba, II, Gazdar, AF, Minna, JD, Pertsemlidis, A: miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers. PLoS One 7:e39167, 2012
Awasthi, N, Zhang, C, Ruan, W, Schwarz, MA, Schwarz, RE: Evaluation of poly-mechanistic antiangiogenic combinations to enhance cytotoxic therapy response in pancreatic cancer. PLoS One 7:e38477, 2012
Yao, Y, Fan, Y, Wu, J, Wan, H, Wang, J, Lam, S, Lam, WL, Girard, L, Gazdar, AF, Wu, Z, Zhou, Q: Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis. Biochem Biophys Res Commun 423:613-9, 2012
Hu, J, Lu, JY, Wong, AM, Hynan, LS, Birnbaum, SG, Yilmaz, DS, Streit, BM, Lenartowicz, EM, Thompson, TC, Cooper, JD, Hofmann, SL: Intravenous high-dose enzyme replacement therapy with recombinant palmitoyl-protein thioesterase reduces visceral lysosomal storage and modestly prolongs survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis. Mol Genet Metab 107:213-21, 2012
Jeong, Y, Xie, Y, Lee, W, Bookout, AL, Girard, L, Raso, G, Behrens, C, Wistuba, II, Gadzar, AF, Minna, JD, Mangelsdorf, DJ: Research resource: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer. Mol Endocrinol 26:1443-54, 2012
Chlebowski, RT, McTiernan, A, Wactawski-Wende, J, Manson, JE, Aragaki, AK, Rohan, T, Ipp, E, Kaklamani, VG, Vitolins, M, Wallace, R, Gunter, M, Phillips, LS, Strickler, H, Margolis, K, Euhus, DM: Diabetes, metformin, and breast cancer in postmenopausal women. J Clin Oncol 30:2844-52, 2012
Kirane, A, Toombs, JE, Larsen, JE, Ostapoff, KT, Meshaw, KR, Zaknoen, S, Brekken, RA, Burrows, FJ: Epithelial-mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib. Carcinogenesis 33:1639-46, 2012
Lockwood, WW, Wilson, IM, Coe, BP, Chari, R, Pikor, LA, Thu, KL, Solis, LM, Nunez, MI, Behrens, C, Yee, J, English, J, Murray, N, Tsao, MS, Minna, JD, Gazdar, AF, Wistuba, II, MacAulay, CE, Lam, S, Lam, WL: Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development. PLoS One 7:e37775, 2012
Selamat, SA, Chung, BS, Girard, L, Zhang, W, Zhang, Y, Campan, M, Siegmund, KD, Koss, MN, Hagen, JA, Lam, WL, Lam, S, Gazdar, AF, Laird-Offringa, IA: Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. Genome Res 22:1197-1211, 2012
Lynn, KD, Brekken, RA: Anti-VEGF therapy revived by c-Met inhibition, but is c-Met the answer? Cancer Discov 2:211-3, 2012
Elshazley, M, Sato, M, Hase, T, Yamashita, R, Yoshida, K, Toyokuni, S, Ishiguro, F, Osada, H, Sekido, Y, Yokoi, K, Usami, N, Shames, DS, Kondo, M, Gazdar, AF, Minna, JD, Hasegawa, Y: The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma. Int J Cancer, 2012
Asterholm, IW, McDonald, J, Blanchard, PG, Sinha, M, Xiao, Q, Mistry, J, Rutkowski, JM, Deshaies, Y, Brekken, RA, Scherer, PE: Lack of "immunological fitness" during fasting in metabolically challenged animals. J Lipid Res 53:1254-67, 2012
Sun, K, Asterholm, IW, Kusminski, CM, Bueno, AC, Wang, ZV, Pollard, JW, Brekken, RA, Scherer, PE: Dichotomous effects of VEGF-A on adipose tissue dysfunction. Proc Natl Acad Sci U S A, 2012
Sun, K, Wernstedt Asterholm, I, Kusminski, CM, Bueno, AC, Wang, ZV, Pollard, JW, Brekken, RA, Scherer, PE: Dichotomous effects of VEGF-A on adipose tissue dysfunction. Proc Natl Acad Sci U S A 109:5874-9, 2012
Schwarz, MA, Thornton, J, Xu, H, Awasthi, N, Schwarz, RE: Cell proliferation and migration are modulated by Cdk-1-phosphorylated endothelial-monocyte activating polypeptide II. PLoS One 7:e33101, 2012
Thu, KL, Vucic, EA, Chari, R, Zhang, W, Lockwood, WW, English, JC, Fu, R, Wang, P, Feng, Z, Macaulay, CE, Gazdar, AF, Lam, S, Lam, WL: Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability. PloS one 7:e33003, 2012
Euhus, D: Managing the breast in patients who test positive for hereditary breast cancer. Ann Surg Oncol 19:1738-44, 2012
Masciari, S, Dillon, DA, Rath, M, Robson, M, Weitzel, JN, Balmana, J, Gruber, SB, Ford, JM, Euhus, D, Lebensohn, A, Telli, M, Pochebit, SM, Lypas, G, Garber, JE: Breast cancer phenotype in women with TP53 germline mutations: a Li-Fraumeni syndrome consortium effort. Breast Cancer Res Treat 133:1125-30, 2012
Xie, Y, Minna, JD: A lung cancer molecular prognostic test ready for prime time. Lancet 379:785-7, 2012
Arnold, SA, Rivera, LB, Carbon, JG, Toombs, JE, Chang, CL, Bradshaw, AD, Brekken, RA: Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGFbeta activation. PLoS One 7:e31384, 2012
Li, G, Guillaud, M, le Riche, J, McWilliams, A, Gazdar, A, Lam, S, Macaulay, C: Automated sputum cytometry for detection of intraepithelial neoplasias in the lung. Analytical cellular pathology, 2012
Benson, DD, Beck, AW, Burdine, MS, Brekken, R, Silliman, CC, Barnett, CC, Jr.: Accumulation of pro-cancer cytokines in the plasma fraction of stored packed red cells. J Gastrointest Surg 16:460-8, 2012
Chang, J, Varghese, DS, Gillam, MC, Peyton, M, Modi, B, Schiltz, RL, Girard, L, Martinez, ED: Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide. Br J Cancer 106:116-25, 2012
Horio, M, Sato, M, Takeyama, Y, Elshazley, M, Yamashita, R, Hase, T, Yoshida, K, Usami, N, Yokoi, K, Sekido, Y, Kondo, M, Toyokuni, S, Gazdar, AF, Minna, JD, Hasegawa, Y: Transient but Not Stable ZEB1 Knockdown Dramatically Inhibits Growth of Malignant Pleural Mesothelioma Cells. Ann Surg Oncol 19 Suppl 3:634-45, 2012
Li, Y, Martin, BR, Cravatt, BF, Hofmann, SL: DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells. J Biol Chem 287:523-30, 2012
Kirov, A, Al-Hashimi, H, Solomon, P, Mazur, C, Thorpe, PE, Sims, PJ, Tarantini, F, Kumar, TK, Prudovsky, I: Phosphatidylserine externalization and membrane blebbing are involved in the nonclassical export of FGF1. J Cell Biochem 113:956-66, 2012
Awasthi, N, Yen, PL, Schwarz, MA, Schwarz, RE: The efficacy of a novel, dual PI3K/mTOR inhibitor NVP-BEZ235 to enhance chemotherapy and antiangiogenic response in pancreatic cancer. J Cell Biochem 113:784-91, 2012
Dasgupta, S, Soudry, E, Mukhopadhyay, N, Shao, C, Yee, J, Lam, S, Lam, W, Zhang, W, Gazdar, AF, Fisher, PB, Sidransky, D: Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression and associated with EGFR gene mutation. Journal of cellular physiology 227:2451-60, 2012
2011
Zhao, D, Stafford, JH, Zhou, H, Thorpe, PE: Near-infrared Optical Imaging of Exposed Phosphatidylserine in a Mouse Glioma Model. Transl Oncol 4:355-64, 2011
Dellinger, MT, Brekken, RA: Phosphorylation of Akt and ERK1/2 is required for VEGF-A/VEGFR2-induced proliferation and migration of lymphatic endothelium. PLoS One 6:e28947, 2011
Gazdar, AF, Schiller, JH: Predictive and Prognostic Factors for Non-Small Cell Lung Cancer--Potholes in the Road to the Promised Land. J Natl Cancer Inst, 2011
Larsen, JE, Cascone, T, Gerber, DE, Heymach, JV, Minna, JD: Targeted therapies for lung cancer: clinical experience and novel agents. Cancer J 17:512-27, 2011
Gazdar, AF, Zhang, YA: Research highlights. Epigenomics 3:405-7, 2011
Gazdar, AF, Brambilla, E: Preneoplasia of lung cancer. Cancer Biomark 9:385-96, 2011
Horio, M, Sato, M, Takeyama, Y, Elshazley, M, Yamashita, R, Hase, T, Yoshida, K, Usami, N, Yokoi, K, Sekido, Y, Kondo, M, Toyokuni, S, Gazdar, AF, Minna, JD, Hasegawa, Y: Transient but Not Stable ZEB1 Knockdown Dramatically Inhibits Growth of Malignant Pleural Mesothelioma Cells. Ann Surg Oncol, 2011
Toyooka, S, Gazdar, AF: Methylation profiling of lung cancer: a decade of progress. Mol Cancer Ther 10:2020, 2011
Larsen, JE, Minna, JD: Molecular biology of lung cancer: clinical implications. Clin Chest Med 32:703-40, 2011
Lam, DC, Minna, JD: How do we safely get people to stop smoking? Cancer Prev Res (Phila) 4:1724-7, 2011
Greer, RM, Peyton, M, Larsen, JE, Girard, L, Xie, Y, Gazdar, AF, Harran, P, Wang, L, Brekken, RA, Wang, X, Minna, JD: SMAC mimetic (JP1201) sensitizes non-small cell lung cancers to multiple chemotherapy agents in an IAP-dependent but TNF-alpha-independent manner. Cancer Res 71:7640-8, 2011
Gerber, DE, Stopeck, AT, Wong, L, Rosen, LS, Thorpe, PE, Shan, JS, Ibrahim, NK: Phase I safety and pharmacokinetic study of bavituximab, a chimeric phosphatidylserine-targeting monoclonal antibody, in patients with advanced solid tumors. Clin Cancer Res 17:6888-96, 2011
Starczynowski, DT, Lockwood, WW, Delehouzee, S, Chari, R, Wegrzyn, J, Fuller, M, Tsao, MS, Lam, S, Gazdar, AF, Lam, WL, Karsan, A: TRAF6 is an amplified oncogene bridging the RAS and NF-kappaB pathways in human lung cancer. J Clin Invest, 2011
Taguchi, A, Politi, K, Pitteri, SJ, Lockwood, WW, Faca, VM, Kelly-Spratt, K, Wong, CH, Zhang, Q, Chin, A, Park, KS, Goodman, G, Gazdar, AF, Sage, J, Dinulescu, DM, Kucherlapati, R, Depinho, RA, Kemp, CJ, Varmus, HE, Hanash, SM: Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell 20:289-99, 2011
Shay, JW, Cucinotta, FA, Sulzman, FM, Coleman, CN, Minna, JD: From mice and men to earth and space: joint NASA-NCI workshop on lung cancer risk resulting from space and terrestrial radiation. Cancer Res 71:6926-9, 2011
Nomura, M, Fukuda, T, Fujii, K, Kawamura, T, Tojo, H, Kihara, M, Bando, Y, Gazdar, AF, Tsuboi, M, Oshiro, H, Nagao, T, Ohira, T, Ikeda, N, Gotoh, N, Kato, H, Marko-Varga, G, Nishimura, T: Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study. J Clin Bioinforma 1:23, 2011
Girotti, MR, Fernandez, M, Lopez, JA, Camafeita, E, Fernandez, EA, Albar, JP, Benedetti, LG, Valacco, MP, Brekken, RA, Podhajcer, OL, Llera, AS: SPARC promotes cathepsin B-mediated melanoma invasiveness through a collagen I/alpha2beta1 integrin axis. J Invest Dermatol 131:2438-47, 2011
Awasthi, N, Schwarz, MA, Schwarz, RE: Antitumour activity of sunitinib in combination with gemcitabine in experimental pancreatic cancer. HPB (Oxford) 13:597-604, 2011
DeRose, P, Thorpe, PE, Gerber, DE: Development of bavituximab, a vascular targeting agent with immune-modulating properties, for lung cancer treatment. Immunotherapy 3:933-44, 2011
Dasgupta, S, Soudry, E, Mukhopadhyay, N, Shao, C, Yee, J, Lam, S, Lam, W, Zhang, W, Gazdar, AF, Fisher, PB, Sidransky, D: Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression and associated with EGFR gene mutation. J Cell Physiol, 2011
Rivera, LB, Bradshaw, AD, Brekken, RA: The regulatory function of SPARC in vascular biology. Cell Mol Life Sci 68:3165-73, 2011
Thu, KL, Pikor, LA, Chari, R, Wilson, IM, Macaulay, CE, English, JC, Tsao, MS, Gazdar, AF, Lam, S, Lam, WL, Lockwood, WW: Genetic Disruption of KEAP1/CUL3 E3 Ubiquitin Ligase Complex Components is a Key Mechanism of NF-KappaB Pathway Activation in Lung Cancer. J Thorac Oncol 6:1521-1529, 2011
Euhus, D, Bu, D, Xie, XJ, Sarode, V, Ashfaq, R, Hunt, K, Xia, W, O'Shaughnessy, J, Grant, M, Arun, B, Dooley, W, Miller, A, Flockhart, D, Lewis, C: Tamoxifen downregulates ets oncogene family members ETV4 and ETV5 in benign breast tissue: implications for durable risk reduction. Cancer Prev Res (Phila) 4:1852-62, 2011
Zhang, YA, Maitra, A, Hsieh, JT, Rudin, CM, Peacock, C, Karikari, C, Brekken, RA, Stastny, V, Gao, B, Girard, L, Wistuba, I, Frenkel, E, Minna, JD, Gazdar, AF: Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts. Cancer Biol Ther 12, 2011
Zhang, YA, Maitra, A, Hsieh, JT, Rudin, CM, Peacock, CD, Karikari, C, Brekken, RA, Stastny, V, Gao, B, Girard, L, Wistuba, I, Frenkel, E, Minna, JD, Gazdar, AF: Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts. Cancer Biol Ther 12:617-28, 2011
Xie, Y, Xiao, G, Coombes, KR, Behrens, C, Solis, LM, Raso, G, Girard, L, Erickson, HS, Roth, J, Heymach, JV, Moran, C, Danenberg, K, Minna, JD, Wistuba, II: Robust gene expression signature from formalin-fixed paraffin-embedded samples predicts prognosis of non-small-cell lung cancer patients. Clin Cancer Res 17:5705-14, 2011
Rivera, LB, Brekken, RA: SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-beta1 activity. J Cell Biol 193:1305-19, 2011
Harris, BS, Zhang, Y, Card, L, Rivera, LB, Brekken, RA, Bradshaw, AD: SPARC regulates collagen interaction with cardiac fibroblast cell surfaces. Am J Physiol Heart Circ Physiol 301:H841-7, 2011
Huang, X, Ye, D, Thorpe, PE: Enhancing the potency of a whole-cell breast cancer vaccine in mice with an antibody-IL-2 immunocytokine that targets exposed phosphatidylserine. Vaccine 29:4785-93, 2011
Hill, VK, Ricketts, C, Bieche, I, Vacher, S, Gentle, D, Lewis, C, Maher, ER, Latif, F: Genome-wide DNA methylation profiling of CpG islands in breast cancer identifies novel genes associated with tumorigenicity. Cancer Res 71:2988-99, 2011
Galindo, CL, McIver, LJ, Tae, H, McCormick, JF, Skinner, MA, Hoeschele, I, Lewis, CM, Minna, JD, Boothman, DA, Garner, HR: Sporadic breast cancer patients' germline DNA exhibit an AT-rich microsatellite signature. Genes Chromosomes Cancer 50:275-83, 2011
Hogg, RT, Thorpe, P, Gerard, RD: Retargeting adenoviral vectors to improve gene transfer into tumors. Cancer Gene Ther 18:275-87, 2011
Ramesh, S, Morrell, CN, Tarango, C, Thomas, GD, Yuhanna, IS, Girardi, G, Herz, J, Urbanus, RT, de Groot, PG, Thorpe, PE, Salmon, JE, Shaul, PW, Mineo, C: Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via beta2GPI and apoER2. J Clin Invest 121:120-31, 2011
Awasthi, N, Schwarz, MA, Schwarz, RE: Enhancing cytotoxic agent activity in experimental pancreatic cancer through EMAP II combination therapy. Cancer Chemother Pharmacol 68:571-82, 2011
Vasalatiy, O, Zhao, P, Woods, M, Marconescu, A, Castillo-Muzquiz, A, Thorpe, P, Kiefer, GE, Sherry, AD: Strategies for labeling proteins with PARACEST agents. Bioorg Med Chem 19:1106-14, 2011
Liang, Y, Besch-Williford, C, Benakanakere, I, Thorpe, PE, Hyder, SM: Targeting mutant p53 protein and the tumor vasculature: an effective combination therapy for advanced breast tumors. Breast Cancer Res Treat 125:407-20, 2011
Sunaga N, Imai H, Shimizu K, Shames DS, Kakegawa S, Girard L, Sato M, Kaira K, Ishizuka T, Gazdar AF, Minna JD, Mori M: Oncogenic KRAS-induced interleukin-8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non-small cell lung cancer. International Journal of Cancer, 2011
Hase T, Sato M, Yoshida K, Girard L, Takeyama Y, Horio M, Elshazley M, Oguri T, Sekido Y, Shames DS, Gazdar AF, Minna JD, Kondo M, Hasegawa Y: A Pivotal Role for Epithelial Cell Adhesion Molecule (EpCAM) in the Survival of Lung Cancer Cells. Cancer Science, 2011
Gazdar AF: Tyrosine Kinase Inhibitors and Epidermal Growth Factor Receptor (EGFR) Mutations in Non-Small Cell Lung Cancer: To Test or Not to Test? Medicine (Baltimore) 90:168-70, 2011
Sierko E, Wojtukiewicz MZ, Zimnoch L, Thorpe PE, Brekken RA, Kisiel W: Co-localization of Prothrombin Fragment F1+2 and VEGF-R2-Bound VEGF in Human Colon Cancer. Anticancer Research 31:843-7, 2011
Stafford JH, Thorpe PE: Increased exposure of phosphatidylethanolamine on the surface of tumor vascular endothelium. Neoplasia 13:299-308, 2011
Carbone M, Ly BH, Dodson RF, Pagano I, Morris PT, Dogan UA, Gazdar AF, Pass HI, Yang H:Malignant mesothelioma: Facts, myths and hypotheses. Journal of Cellular Physiology, 2011
Euhus DM: New insights into the prevention and treatment of familial breast cancer. Journal of Surgical Oncology 103:294-8, 2011
Ou YH, Torres M, Ram R, Formstecher E, Roland C, Cheng T, Brekken R, Wurz R, Tasker A, Polverino T, Tan SL, White MA: TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation. Molecular Cell 41:458-70, 2011
Sunaga N, Shames DS, Girard L, Peyton M, Larsen JE, Imai H, Soh J, Sato M, Yanagitani N, Kaira K, Xie Y, Gazdar AF, Mori M, Minna JD: Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy. Molecular Cancer Theraputics 10:336-46, 2011
Schwarz RE: Challenges with demographic disparities in gastric cancer care and survival: spectral rather than black and white. Cancer Epidemiology Biomarkers and Prevention 20:221-2, 2011
Tang X, Kadara H, Behrens C, Liu D, Xiao Y, Rice DC, Gazdar AF, Fujimoto J, Moran C, Varella-Garcia M, Lee JJ, Hong WK, Wistuba, II: Abnormalities of the TITF-1 lineage-specific oncogene in NSCLC: Implications in lung cancer pathogenesis and prognosis. Clinical Cancer Research, 2011
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D:International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. Journal of Thoracic Oncology 6:244-85, 2011
Best AM, Chang J, Dull AB, Beutler JA, Martinez ED: Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell-based assay. Journal of Biomedicine and Biotechnology:868095, 2011
Awasthi N, Kirane A, Schwarz MA, Toombs JE, Brekken RA, Schwarz RE: Smac mimetic-derived augmentation of chemotherapeutic response in experimental pancreatic cancer. Biomed Central 11:15, 2011
Li LS, Bey EA, Dong Y, Meng J, Patra B, Yan J, Xie XJ, Brekken RA, Barnett CC, Bornmann WG, Gao J, Boothman DA: Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of beta-lapachone for pancreatic cancer therapy. Clinical Cancer Research 17:275-85, 2011
Chandra M, Zhou H, Li Q, Muallem S, Hofmann SL, Soyombo AA: A role for the Ca2+ channel TRPML1 in gastric acid secretion, based on analysis of knockout mice. Gastroenterology 140:857-67, 2011
Rule W, Timmerman R, Tong L, Abdulrahman R, Meyer J, Boike T, Schwarz RE, Weatherall P, Chinsoo Cho L: Phase I dose-escalation study of stereotactic body radiotherapy in patients with hepatic metastases. Annals of Surgical Oncology 18:1081-7, 2011
Mansour JC, Schwarz RE: Resection of type I gastric carcinoid: when and why? Journal of Surgical Research 166:68-9, 2011
Yamaguchi S, Jha A, Li Q, Soyombo AA, Dickinson GD, Churamani D, Brailoiu E, Patel S, Muallem S: TRPML1 and the two-pore channels are functionally independent organellar ion channels. Journal of Biological Chemistry, 2011
2010
Tokuyama Y, Takahashi T, Okumura N, Nonaka K, Kawaguchi Y, Yamaguchi K, Osada S, Gazdar A, Yoshida K: Aberrant methylation of heparan sulfate glucosamine 3-O-sulfotransferase 2 genes as a biomarker in colorectal cancer. Anticancer Research 30:4811-8, 2010
Jeong Y, Xie Y, Xiao G, Behrens C, Girard L, Wistuba, II, Minna JD, Mangelsdorf DJ: Nuclear receptor expression defines a set of prognostic biomarkers for lung cancer. PLoS Medicine 7:e1000378, 2010
Gerber DE, Minna JD: ALK inhibition for non-small cell lung cancer: from discovery to therapy in record time. Cancer Cell 18:548-51, 2010
Sullivan JP, Spinola M, Dodge M, Raso MG, Behrens C, Gao B, Schuster K, Shao C, Larsen JE, Sullivan LA, Honorio S, Xie Y, Scaglioni PP, DiMaio JM, Gazdar AF, Shay JW, Wistuba, II, Minna JD: Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Research 70:9937-48, 2010
Chandra M, Zhou H, Li Q, Muallem S, Hofmann SL, Soyombo AA: A Role for the Ca(2+) Channel TRPML1 in Gastric Acid Secretion, Based on Analysis of Knockout Mice. Gastroenterology, 2010
Awasthi N, Schwarz MA, Schwarz RE: Enhancing cytotoxic agent activity in experimental pancreatic cancer through EMAP II combination therapy. Cancer Chemotherapy and Pharmacology, 2010
Ramos AL, Darabi R, Akbarloo N, Borges L, Catanese J, Dineen SP, Brekken RA, Perlingeiro RC: Clonal analysis reveals a common progenitor for endothelial, myeloid, and lymphoid precursors in umbilical cord blood. Circulation Research 107:1460-9, 2010
Gazdar AF: Should we continue to use the term non-small-cell lung cancer? Annals of Oncology 21 Suppl 7:vii225-vii229, 2010
Xie Y, Minna JD: Non-small-cell lung cancer mRNA expression signature predicting response to adjuvant chemotherapy. Journal of Clinical Oncology 28:4404-7, 2010
De Leon-Rodriguez LM, Lubag A, Udugamasooriya DG, Proneth B, Brekken RA, Sun X, Kodadek T, Dean Sherry A: MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting. Journal of the American Chemical Society 132:12829-31, 2010
Sullivan LA, Carbon JG, Roland CL, Toombs JE, Nyquist-Andersen M, Kavlie A, Schlunegger K, Richardson JA, Brekken RA: r84, a novel therapeutic antibody against mouse and human VEGF with potent anti-tumor activity and limited toxicity induction. PLoS One 5:e12031, 2010
Das AK, Bell MH, Nirodi CS, Story MD, Minna JD: Radiogenomics predicting tumor responses to radiotherapy in lung cancer. Seminars in Radiation Oncology 20:149-55, 2010
Saha D, Watkins L, Yin Y, Thorpe P, Story MD, Song K, Raghavan P, Timmerman R, Chen B, Minna JD, Solberg TD: An orthotopic lung tumor model for image-guided microirradiation in rats. Radiation Research 174:62-71, 2010
Gazdar AF, Girard L, Lockwood WW, Lam WL, Minna JD: Lung cancer cell lines as tools for biomedical discovery and research. Journal of the National Cancer Institute 102:1310-21, 2010
Lynn KD, Udugamasooriya DG, Roland CL, Castrillon DH, Kodadek TJ, Brekken RA: GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer. Biomed Central 10:397, 2010
Lockwood WW, Chari R, Coe BP, Thu KL, Garnis C, Malloff CA, Campbell J, Williams AC, Hwang D, Zhu CQ, Buys TP, Yee J, English JC, Macaulay C, Tsao MS, Gazdar AF, Minna JD, Lam S, Lam WL: Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma. PLoS Medicine 7:e1000315, 2010
Cai D, Shames DS, Raso MG, Xie Y, Kim YH, Pollack JR, Girard L, Sullivan JP, Gao B, Peyton M, Nanjundan M, Byers L, Heymach J, Mills G, Gazdar AF, Wistuba I, Kodadek T, Minna JD:Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation. Cancer Research 70:6477-85, 2010
Korpanty G, Sullivan LA, Smyth E, Carney DN, Brekken RA: Molecular and clinical aspects of targeting the VEGF pathway in tumors. Journal of Oncology 2010:652320, 2010
Du L, Schageman JJ, Irnov, Girard L, Hammond SM, Minna JD, Gazdar AF, Pertsemlidis A:MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs. Journal of Experimental and Clinical Cancer Research 29:75, 2010
Sullivan JP, Minna JD: Tumor oncogenotypes and lung cancer stem cell identity. Cell Stem Cell 7:2-4, 2010
Villasenor A, Wang ZV, Rivera LB, Ocal O, Asterholm IW, Scherer PE, Brekken RA, Cleaver O, Wilkie TM: Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes. Disease Models and Mechanisms 3:567-80, 2010
Schwarz RE, Abou-Alfa GK, Geschwind JF, Krishnan S, Salem R, Venook AP: Nonoperative therapies for combined modality treatment of hepatocellular cancer: expert consensus statement. HPB (Oxford) 12:313-20, 2010
Dixon E, Abdalla E, Schwarz RE, Vauthey JN: AHPBA/SSO/SSAT sponsored Consensus Conference on Multidisciplinary Treatment of Hepatocellular Carcinoma. HPB (Oxford) 12:287-8, 2010
Chambliss KL, Wu Q, Oltmann S, Konaniah ES, Umetani M, Korach KS, Thomas GD, Mineo C, Yuhanna IS, Kim SH, Madak-Erdogan Z, Maggi A, Dineen SP, Roland CL, Hui DY, Brekken RA, Katzenellenbogen JA, Katzenellenbogen BS, Shaul PW: Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice. Journal of Clinical Investigation 120:2319-30, 2010
Barnett CC, Jr., Beck AW, Holloway SE, Kehler M, Schluterman MK, Brekken RA, Fleming JB, Silliman CC: Intravenous delivery of the plasma fraction of stored packed erythrocytes promotes pancreatic cancer growth in immunocompetent mice. Cancer 116:3862-74, 2010
Gazdar AF, Boffetta P: A risky business--identifying susceptibility loci for lung cancer. Journal of the National Cancer Institute 102:920-3, 2010
Awasthi N, Schwarz MA, Schwarz RE: Combination effects of bortezomib with gemcitabine and EMAP II in experimental pancreatic cancer. Cancer Biology and Therapy 10:99-107, 2010
Sanders DN, Farias FH, Johnson GS, Chiang V, Cook JR, O'Brien DP, Hofmann SL, Lu JY, Katz ML: A mutation in canine PPT1 causes early onset neuronal ceroid lipofuscinosis in a Dachshund. Molecular Genetics and Metabolism 100:349-56, 2010
Benedettini E, Sholl LM, Peyton M, Reilly J, Ware C, Davis L, Vena N, Bailey D, Yeap BY, Fiorentino M, Ligon AH, Pan BS, Richon V, Minna JD, Gazdar AF, Draetta G, Bosari S, Chirieac LR, Lutterbach B, Loda M: Met Activation in Non-Small Cell Lung Cancer Is Associated with de Novo Resistance to EGFR Inhibitors and the Development of Brain Metastasis. American Journal of Pathology, 2010
Takeyama Y, Sato M, Horio M, Hase T, Yoshida K, Yokoyama T, Nakashima H, Hashimoto N, Sekido Y, Gazdar AF, Minna JD, Kondo M, Hasegawa Y: Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells. Cancer Letters, 2010
Roland CL, Dineen SP, Toombs JE, Carbon JG, Smith CW, Brekken RA, Barnett CC, Jr.:Tumor-derived intercellular adhesion molecule-1 mediates tumor-associated leukocyte infiltration in orthotopic pancreatic xenografts. Experimental Biology and Medicine (Maywood) 235:263-70, 2010
Korpanty G, Smyth E, Sullivan LA, Brekken RA, Carney DN: Antiangiogenic therapy in lung cancer: focus on vascular endothelial growth factor pathway. Experimental Biology and Medicine (Maywood) 235:3-9, 2010
Hohenstein B, Colin M, Foellmer C, Amann KU, Brekken RA, Daniel C, Hugo CP: Autocrine VEGF-VEGF-R loop on podocytes during glomerulonephritis in humans. Nephrology Dialysis Transplantation 25:3170-80, 2010
Liu P, Yang P, Wu X, Vikis HG, Lu Y, Wang Y, Schwartz AG, Pinney SM, de Andrade M, Gazdar A, Gaba C, Mandal D, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Spitz M, Amos CI, Anderson MW, You M: A second genetic variant on chromosome 15q24-25.1 associates with lung cancer. Cancer Research 70:3128-35, 2010
Holbeck S, Chang J, Best AM, Bookout AL, Mangelsdorf DJ, Martinez ED: Expression profiling of nuclear receptors in the NCI60 cancer cell panel reveals receptor-drug and receptor-gene interactions. Molecular Endocrinology 24:1287-96, 2010
Bo LE, Gjerald SU, Brekken R, Tangen GA, Hernes TA: Efficiency of ultrasound training simulators: method for assessing image realism. Minimally Invasive Therapy and Allied Technologies 19:69-74, 2010
Dineen SP, Roland CL, Greer R, Carbon JG, Toombs JE, Gupta P, Bardeesy N, Sun H, Williams N, Minna JD, Brekken RA: Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer. Cancer Research 70:2852-61, 2010
Spinola M, Falvella FS, Colombo F, Sullivan JP, Shames DS, Girard L, Spessotto P, Minna JD, Dragani TA: MFSD2A is a novel lung tumor suppressor gene modulating cell cycle and matrix attachment. Molecular Cancer 9:62, 2010
Amos CI, Pinney SM, Li Y, Kupert E, Lee J, de Andrade MA, Yang P, Schwartz AG, Fain PR, Gazdar A, Minna J, Wiest JS, Zeng D, Rothschild H, Mandal D, You M, Coons T, Gaba C, Bailey-Wilson JE, Anderson MW: A susceptibility locus on chromosome 6q greatly increases lung cancer risk among light and never smokers. Cancer Research 70:2359-67, 2010
Schwarz RE, Awasthi N, Konduri S, Caldwell L, Cafasso D, Schwarz MA: Antitumor effects of EMAP II against pancreatic cancer through inhibition of fibronectin-dependent proliferation. Cancer Biology and Therapy 9:632-9, 2010
Hill VK, Hesson LB, Dansranjavin T, Dallol A, Bieche I, Vacher S, Tommasi S, Dobbins T, Gentle D, Euhus D, Lewis C, Dammann R, Ward RL, Minna J, Maher ER, Pfeifer GP, Latif F:Identification of 5 novel genes methylated in breast and other epithelial cancers. Molecular Cancer 9:51, 2010
Schluterman MK, Chapman SL, Korpanty G, Ozumi K, Fukai T, Yanagisawa H, Brekken RA:Loss of fibulin-5 binding to beta1 integrins inhibits tumor growth by increasing the level of ROS. Disease Models and Mechanisms 3:333-42, 2010
Shivapurkar N, Gazdar AF: DNA Methylation Based Biomarkers in Non-Invasive Cancer Screening. Current Molecular Medicine, 2010
Sullivan LA, Brekken RA: The VEGF family in cancer and antibody-based strategies for their inhibition. MAbs 2, 2010
Li Y, Hu J, Hofer K, Wong AM, Cooper JD, Birnbaum SG, Hammer RE, Hofmann SL: DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory. Journal of Biological Chemistry 285:13022-31, 2010
Xu L, Nilsson MB, Saintigny P, Cascone T, Herynk MH, Du Z, Nikolinakos PG, Yang Y, Prudkin L, Liu D, Lee JJ, Johnson FM, Wong KK, Girard L, Gazdar AF, Minna JD, Kurie JM, Wistuba, II, Heymach JV: Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1alpha in non-small cell lung cancer cells. Oncogene, 2010
Liu P, Vikis HG, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Gazdar A, Gaba C, Mandal D, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW, You M: Cumulative effect of multiple Loci on genetic susceptibility to familial lung cancer. Cancer Epidemiology Biomarkers and Prevention 19:517-24, 2010
Gazdar AF: Epidermal growth factor receptor inhibition in lung cancer: the evolving role of individualized therapy. Cancer and Metastasis Review, 2010
Ishizumi T, McWilliams A, Macaulay C, Gazdar A, Lam S: Natural history of bronchial preinvasive lesions. Cancer and Metastasis Review, 2010
Chari R, Thu KL, Wilson IM, Lockwood WW, Lonergan KM, Coe BP, Malloff CA, Gazdar AF, Lam S, Garnis C, Macaulay CE, Alvarez CE, Lam WL: Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer. Cancer and Metastasis Review, 2010
Gazdar AF: Preface. Cancer and Metastasis Review, 2010
Sullivan JP, Minna JD, Shay JW: Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy. Cancer and Metastasis Review 29:61-72, 2010
Gazdar AF, Gao B, Minna JD: Lung cancer cell lines: Useless artifacts or invaluable tools for medical science? Lung Cancer 68:309-18, 2010
Alberts SR, Roh MS, Mahoney MR, O'Connell MJ, Nagorney DM, Wagman L, Smyrk TC, Weiland TL, Lai LL, Schwarz RE, Molina R, Dentchev T, Bolton JS: Alternating systemic and hepatic artery infusion therapy for resected liver metastases from colorectal cancer: a North Central Cancer Treatment Group (NCCTG)/ National Surgical Adjuvant Breast and Bowel Project (NSABP) phase II intergroup trial, N9945/CI-66. Journal of Clinical Oncology 28:853-8, 2010
Schwarz RE, Awasthi N, Konduri S, Cafasso D, Schwarz MA: EMAP II-based antiangiogenic-antiendothelial in vivo combination therapy of pancreatic cancer. Annals of Surgical Oncology 17:1442-52, 2010
Lu JY, Hu J, Hofmann SL: Human recombinant palmitoyl-protein thioesterase-1 (PPT1) for preclinical evaluation of enzyme replacement therapy for infantile neuronal ceroid lipofuscinosis. Molecular Genetics and Metabolism 99:374-378, 2010
Pleasance ED, Stephens PJ, O'Meara S, McBride DJ, Meynert A, Jones D, Lin ML, Beare D, Lau KW, Greenman C, Varela I, Nik-Zainal S, Davies HR, Ordonez GR, Mudie LJ, Latimer C, Edkins S, Stebbings L, Chen L, Jia M, Leroy C, Marshall J, Menzies A, Butler A, Teague JW, Mangion J, Sun YA, McLaughlin SF, Peckham HE, Tsung EF, Costa GL, Lee CC, Minna JD, Gazdar A, Birney E, Rhodes MD, McKernan KJ, Stratton MR, Futreal PA, Campbell PJ: A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature 463:184-90, 2010
Arnold SA, Rivera LB, Miller AF, Carbon JG, Dineen SP, Xie Y, Castrillon DH, Sage EH, Puolakkainen P, Bradshaw AD, Brekken RA: Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma. Disease Models and Mechanisms 3:57-72, 2010
Kim YH, Kwei KA, Girard L, Salari K, Kao J, Pacyna-Gengelbach M, Wang P, Hernandez-Boussard T, Gazdar AF, Petersen I, Minna JD, Pollack JR: Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer. Oncogene 29:1421-30, 2010
2009
Awasthi N, Schwarz MA, Schwarz RE: Proteasome inhibition enhances antitumour effects of gemcitabine in experimental pancreatic cancer. HPB (Oxford) 11:600-5, 2009
Kim YH, Kwei KA, Girard L, Salari K, Kao J, Pacyna-Gengelbach M, Wang P, Hernandez-Boussard T, Gazdar AF, Petersen I, Minna JD, Pollack JR: Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer. Oncogene, 2009
Roland CL, Lynn KD, Toombs JE, Dineen SP, Udugamasooriya DG, Brekken RA: Cytokine levels correlate with immune cell infiltration after anti-VEGF therapy in preclinical mouse models of breast cancer. PLoS One 4:e7669, 2009
He J, Yin Y, Luster TA, Watkins L, Thorpe PE: Antiphosphatidylserine antibody combined with irradiation damages tumor blood vessels and induces tumor immunity in a rat model of glioblastoma. Clinical Cancer Research 15:6871-80, 2009
Rudin C, Minna J: Cancer stem cells. Journal of Thoracic Oncology 4:S1079-81, 2009
Soh J, Okumura N, Lockwood WW, Yamamoto H, Shigematsu H, Zhang W, Chari R, Shames DS, Tang X, MacAulay C, Varella-Garcia M, Vooder T, Wistuba, II, Lam S, Brekken R, Toyooka S, Minna JD, Lam WL, Gazdar AF: Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells. PLoS One 4:e7464, 2009
Arnold SA, Brekken RA: SPARC: a matricellular regulator of tumorigenesis. Journal of Cell Communication and Signaling 3:255-73, 2009
Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, O'Kelly M, Dutt A, Rozenblatt-Rosen O, Dziunycz P, Komisarof J, Chirieac LR, Lafargue CJ, Scheble V, Wilbertz T, Ma C, Rao S, Nakagawa H, Stairs DB, Lin L, Giordano TJ, Wagner P, Minna JD, Gazdar AF, Zhu CQ, Brose MS, Cecconello I, Jr UR, Marie SK, Dahl O, Shivdasani RA, Tsao MS, Rubin MA, Wong KK, Regev A, Hahn WC, Beer DG, Rustgi AK, Meyerson M: SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nature Genetics 41:1238-42, 2009
Yanagisawa H, Schluterman MK, Brekken RA: Fibulin-5, an integrin-binding matricellular protein: its function in development and disease. Journal of Cell Communication and Signaling 3:337-47, 2009
Konstantinidou G, Bey EA, Rabellino A, Schuster K, Maira MS, Gazdar AF, Amici A, Boothman DA, Scaglioni PP: Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations. Cancer Research 69:7644-52, 2009
Liu Y, Liu P, Wen W, James MA, Wang Y, Bailey-Wilson JE, Amos CI, Pinney SM, Yang P, de Andrade M, Petersen GM, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Lee J, Seminara D, Minna J, Anderson MW, You M: Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1. Cancer Research 69:7844-50, 2009
Gazdar AF: Personalized medicine and inhibition of EGFR signaling in lung cancer. New England Journal of medicine 361:1018-20, 2009
Gazdar AF: Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors. Oncogene 28 Suppl 1:S24-31, 2009
Albuquerque RJ, Hayashi T, Cho WG, Kleinman ME, Dridi S, Takeda A, Baffi JZ, Yamada K, Kaneko H, Green MG, Chappell J, Wilting J, Weich HA, Yamagami S, Amano S, Mizuki N, Alexander JS, Peterson ML, Brekken RA, Hirashima M, Capoor S, Usui T, Ambati BK, Ambati J:Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. Nature Medicine 15:1023-30, 2009
Chen TT, Rakheja D, Hung JY, Hornsby PJ, Tabaczewski P, Malogolowkin M, Feusner J, Miskevich F, Schultz R, Tomlinson GE: Establishment and characterization of a cancer cell line derived from an aggressive childhood liver tumor. Pediatric Blood and Cancer 53:1040-7, 2009
Lee P, van den Berg RM, Lam S, Gazdar AF, Grunberg K, McWilliams A, Leriche J, Postmus PE, Sutedja TG: Color fluorescence ratio for detection of bronchial dysplasia and carcinoma in situ. Clinical Cancer Research 15:4700-5, 2009
Kao J, Salari K, Bocanegra M, Choi YL, Girard L, Gandhi J, Kwei KA, Hernandez-Boussard T, Wang P, Gazdar AF, Minna JD, Pollack JR: Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery. PLoS One 4:e6146, 2009
Roland CL, Dineen SP, Lynn KD, Sullivan LA, Dellinger MT, Sadegh L, Sullivan JP, Shames DS, Brekken RA: Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts. Molecular Cancer Theraputics 8:1761-71, 2009
Halberg N, Khan T, Trujillo ME, Wernstedt-Asterholm I, Attie AD, Sherwani S, Wang ZV, Landskroner-Eiger S, Dineen S, Magalang UJ, Brekken RA, Scherer PE: Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Molecular and Cellular Biology 29:4467-83, 2009
Kim HJ, Soyombo AA, Tjon-Kon-Sang S, So I, Muallem S: The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy. Traffic 10:1157-67, 2009
Matsuo Y, Campbell PM, Brekken RA, Sung B, Ouellette MM, Fleming JB, Aggarwal BB, Der CJ, Guha S: K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways. Molecular CancerResearch7:799-808, 2009
Brambilla E, Gazdar A: Pathogenesis of lung cancer signalling pathways: roadmap for therapies. European Respiratory Journal 33:1485-97, 2009
Sos ML, Michel K, Zander T, Weiss J, Frommolt P, Peifer M, Li D, Ullrich R, Koker M, Fischer F, Shimamura T, Rauh D, Mermel C, Fischer S, Stuckrath I, Heynck S, Beroukhim R, Lin W, Winckler W, Shah K, Laframboise T, Moriarty WF, Hanna M, Tolosi L, Rahnenfuhrer J, Verhaak R, Chiang D, Getz G, Hellmich M, Wolf J, Girard L, Peyton M, Weir BA, Chen TH, Greulich H, Barretina J, Shapiro GI, Garraway LA, Gazdar AF, Minna JD, Meyerson M, Wong KK, Thomas RK: Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions. Journal of Clinical Investigation, 2009
Arguello AA, Fischer SJ, Schonborn JR, Markus RW, Brekken RA, Eisch AJ: Effect of chronic morphine on the dentate gyrus neurogenic microenvironment. Neuroscience 159:1003-10, 2009
Gazdar AF, Minna JD: Multifocal lung cancers--clonality vs field cancerization and does it matter? Journal of the National Cancer Institute 101:541-3, 2009
Sos ML, Koker M, Weir BA, Heynck S, Rabinovsky R, Zander T, Seeger JM, Weiss J, Fischer F, Frommolt P, Michel K, Peifer M, Mermel C, Girard L, Peyton M, Gazdar AF, Minna JD, Garraway LA, Kashkar H, Pao W, Meyerson M, Thomas RK: PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR. Cancer Research 69:3256-61, 2009
You M, Wang D, Liu P, Vikis H, James M, Lu Y, Wang Y, Wang M, Chen Q, Jia D, Liu Y, Wen W, Yang P, Sun Z, Pinney SM, Zheng W, Shu XO, Long J, Gao YT, Xiang YB, Chow WH, Rothman N, Petersen GM, de Andrade M, Wu Y, Cunningham JM, Wiest JS, Fain PR, Schwartz AG, Girard L, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW: Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. Clinical Cancer Research 15:2666-74, 2009
Mansour JC, Schwarz RE: Pathologic response to preoperative therapy: does it mean what we think it means? Annals of Surgical Oncology 16:1465-79, 2009
Gandhi J, Zhang J, Xie Y, Soh J, Shigematsu H, Zhang W, Yamamoto H, Peyton M, Girard L, Lockwood WW, Lam WL, Varella-Garcia M, Minna JD, Gazdar AF: Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. PLoS One 4:e4576, 2009
Miura N, Sato R, Tsukamoto T, Shimizu M, Kabashima H, Takeda M, Takahashi S, Harada T, West JE, Drabkin H, Mejia JE, Shiota G, Murawaki Y, Virmani A, Gazdar AF, Oshimura M, Hasegawa J: A noncoding RNA gene on chromosome 10p15.3 may function upstream of hTERT. BMC Molecular Biology 10:5, 2009
Zhang W, Peyton M, Xie Y, Soh J, Minna JD, Gazdar AF, Frenkel EP: Histone deacetylase inhibitor romidepsin enhances anti-tumor effect of erlotinib in non-small cell lung cancer (NSCLC) cell lines. Journal of Thoracic Oncology 4:161-6, 2009
Kubo T, Yamamoto H, Lockwood WW, Valencia I, Soh J, Peyton M, Jida M, Otani H, Fujii T, Ouchida M, Takigawa N, Kiura K, Shimizu K, Date H, Minna JD, Varella-Garcia M, Lam WL, Gazdar AF, Toyooka S: MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors. International Journal of Cancer 124:1778-84, 2009
Edell E, Lam S, Pass H, Miller YE, Sutedja T, Kennedy T, Loewen G, Keith RL, Gazdar A:Detection and localization of intraepithelial neoplasia and invasive carcinoma using fluorescence-reflectance bronchoscopy: an international, multicenter clinical trial. Journal of Thoracic Oncology 4:49-54, 2009
Awasthi N, Schwarz MA, Verma V, Cappiello C, Schwarz RE: Endothelial monocyte activating polypeptide II interferes with VEGF-induced proangiogenic signaling. Laboratory Investigation 89:38-46, 2009
Bull Phelps SL, Carbon J, Miller A, Castro-Rivera E, Arnold S, Brekken RA, Lea JS: Secreted protein acidic and rich in cysteine as a regulator of murine ovarian cancer growth and chemosensitivity. American Journal of Obstetrics and Gynecology 200:180 e1-7, 2009
Vazquez M, Carter D, Brambilla E, Gazdar A, Noguchi M, Travis WD, Huang Y, Zhang L, Yip R, Yankelevitz DF, Henschke CI, International Early Lung Cancer Action Program I: Solitary and multiple resected adenocarcinomas after CT screening for lung cancer: histopathologic features and their prognostic implications. Lung Cancer 64:148-54, 2009
Dineen SP, Roland CL, Toombs JE, Kelher M, Silliman CC, Brekken RA, Barnett CC, Jr.: The acellular fraction of stored platelets promotes tumor cell invasion. Journal of Surgical Research 153:132-7, 2009
2008
Dowell J, Minna JD: Small-cell lung cancer: translational research enroute to therapeutic advances. Oncology (Williston Park) 22:1493, 1495, 2008
Gazdar AF, Minna JD: Deregulated EGFR signaling during lung cancer progression: mutations, amplicons, and autocrine loops. Cancer Prevention Research (Phila Pa) 1:156-60, 2008
Slack MD, Martinez ED, Wu LF, Altschuler SJ: Characterizing heterogeneous cellular responses to perturbations. Proceedings of the National Academy of Sciences U S A 105:19306-11, 2008
Dineen SP, Sullivan LA, Beck AW, Miller AF, Carbon JG, Mamluk R, Wong H, Brekken RA: The Adnectin CT-322 is a novel VEGF receptor 2 inhibitor that decreases tumor burden in an orthotopic mouse model of pancreatic cancer. Biomed Central 8:352, 2008
Soares MM, King SW, Thorpe PE: Targeting inside-out phosphatidylserine as a therapeutic strategy for viral diseases. Nature Medicine 14:1357-62, 2008
Pratilas CA, Hanrahan AJ, Halilovic E, Persaud Y, Soh J, Chitale D, Shigematsu H, Yamamoto H, Sawai A, Janakiraman M, Taylor BS, Pao W, Toyooka S, Ladanyi M, Gazdar A, Rosen N, Solit DB: Genetic predictors of MEK dependence in non-small cell lung cancer. Cancer Research 68:9375-83, 2008
Deus HF, Stanislaus R, Behrens C, Wistuba, II, Minna JD, Garner HR, Swisher SG, Roth JA, Correa AM, Broom B, Coombes K, Almeida JS: Data Driven Semantic Integration of Translational Lung Cancer Research at MDAnderson Cancer Center. AMIA Annual Symposium Proceedings:927, 2008
Sangaletti S, Di Carlo E, Gariboldi S, Miotti S, Cappetti B, Parenza M, Rumio C, Brekken RA, Chiodoni C, Colombo MP: Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis. Cancer Research 68:9050-9, 2008
Castro-Rivera E, Ran S, Brekken RA, Minna JD: Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells. Cancer Research 68:8295-303, 2008
Shivapurkar N, Stastny V, Okumura N, Girard L, Xie Y, Prinsen C, Thunnissen FB, Wistuba, II, Czerniak B, Frenkel E, Roth JA, Liloglou T, Xinarianos G, Field JK, Minna JD, Gazdar AF:Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene. Cancer Research 68:7448-56, 2008
Liu P, Vikis HG, Wang D, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Petersen GM, Wiest JS, Fain PR, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Wu X, Spitz MR, Eisen T, Houlston RS, Amos CI, Anderson MW, You M: Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. Journal of the National Cancer Institute 100:1326-30, 2008
Guha U, Chaerkady R, Marimuthu A, Patterson AS, Kashyap MK, Harsha HC, Sato M, Bader JS, Lash AE, Minna JD, Pandey A, Varmus HE: Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS. Proceedings of the National Academy of Sciences U S A 105:14112-7, 2008
Yamamoto H, Shigematsu H, Nomura M, Lockwood WW, Sato M, Okumura N, Soh J, Suzuki M, Wistuba, II, Fong KM, Lee H, Toyooka S, Date H, Lam WL, Minna JD, Gazdar AF: PIK3CA mutations and copy number gains in human lung cancers. Cancer Research 68:6913-21, 2008
Deus HF, Stanislaus R, Veiga DF, Behrens C, Wistuba, II, Minna JD, Garner HR, Swisher SG, Roth JA, Correa AM, Broom B, Coombes K, Chang A, Vogel LH, Almeida JS: A Semantic Web management model for integrative biomedical informatics. PLoS ONE 3:e2946, 2008
Xie Y, Minna JD: Predicting the future for people with lung cancer. Nature Medicine 14:812-3, 2008
Udugamasooriya DG, Dunham G, Ritchie C, Brekken RA, Kodadek T: The pharmacophore of a peptoid VEGF receptor 2 antagonist includes both side chain and main chain residues. Bioorganic & Medicinal Chemistry Letters 18:5892-4, 2008
Marconescu A, Thorpe PE: Coincident exposure of phosphatidylethanolamine and anionic phospholipids on the surface of irradiated cells. Biochimica et Biophysica Acta 1778:2217-24, 2008
Toyooka S, Matsuo K, Gazdar AF: DNA methylation in lung cancer. New England Journal of medicine 358:2513; author reply 2514, 2008
Dineen SP, Lynn KD, Holloway SE, Miller AF, Sullivan JP, Shames DS, Beck AW, Barnett CC, Fleming JB, Brekken RA: Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice. Cancer Research 68:4340-6, 2008
Udugamasooriya DG, Ritchie C, Brekken RA, Kodadek T: A peptoid antagonist of VEGF receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site. Bioorganic & Medicinal Chemistry 16:6338-43, 2008
Euhus DM, Bu D, Milchgrub S, Xie XJ, Bian A, Leitch AM, Lewis CM: DNA methylation in benign breast epithelium in relation to age and breast cancer risk. Cancer Epidemiology Biomarkers and Prevention 17:1051-9, 2008
Majewski T, Lee S, Jeong J, Yoon DS, Kram A, Kim MS, Tuziak T, Bondaruk J, Park WS, Tang KS, Chung W, Shen L, Ahmed SS, Johnston DA, Grossman HB, Dinney CP, Zhou JH, Harris RA, Snyder C, Filipek S, Narod SA, Watson P, Lynch HT, Gazdar A, Bar-Eli M, Wu XF, McConkey DJ, Baggerly K, Issa JP, Benedict WF, Scherer SE, Czerniak B: Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy. Laboratory Investigation 88:694-721, 2008
Einhorn LH, Bonomi P, Bunn PA, Jr., Camidge DR, Carbone DP, Choy H, Dubinett SM, Gandara DR, Gaspar LE, Govindan R, Johnson DH, Minna JD, Scagliotti G, West HJ, Herbst RS:Summary report 7th Annual Targeted Therapies of the Treatment of Lung Cancer. Journal of Thoracic Oncology 3:545-55, 2008
Arnold S, Mira E, Muneer S, Korpanty G, Beck AW, Holloway SE, Manes S, Brekken RA: Forced expression of MMP9 rescues the loss of angiogenesis and abrogates metastasis of pancreatic tumors triggered by the absence of host SPARC. Experimental Biology and Medicine (Maywood) 233:860-73, 2008
Shivapurkar N, Stastny V, Xie Y, Prinsen C, Frenkel E, Czerniak B, Thunnissen FB, Minna JD, Gazdar AF: Differential Methylation of a Short CpG-Rich Sequence within Exon 1 of TCF21 Gene: A Promising Cancer Biomarker Assay. Cancer Epidemiology Biomarkers and Prevention 17:995-1000, 2008
Lockwood WW, Chari R, Coe BP, Girard L, Macaulay C, Lam S, Gazdar AF, Minna JD, Lam WL:DNA amplification is a ubiquitous mechanism of oncogene activation in lung and other cancers. Oncogene 27:4615-24, 2008
Udugamasooriya DG, Dineen SP, Brekken RA, Kodadek T: A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity. Journal of the American Chemical Society 130:5744-52, 2008
Kim HJ, Li Q, Tjon-Kon-Sang S, So I, Kiselyov K, Soyombo AA, Muallem S: A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype. EMBO Journal 27:1197-205, 2008
Whitehurst AW, Ram R, Shivakumar L, Gao B, Minna JD, White MA: The RASSF1A tumor suppressor restrains anaphase-promoting complex/cyclosome activity during the G1/S phase transition to promote cell cycle progression in human epithelial cells. Molecular and Cellular Biology 28:3190-7, 2008
Jennewein M, Lewis MA, Zhao D, Tsyganov E, Slavine N, He J, Watkins L, Kodibagkar VD, O'Kelly S, Kulkarni P, Antich PP, Hermanne A, Rosch F, Mason RP, Thorpe PE: Vascular imaging of solid tumors in rats with a radioactive arsenic-labeled antibody that binds exposed phosphatidylserine. Clinical Cancer Research 14:1377-85, 2008
Iwanaga K, Yang Y, Raso MG, Ma L, Hanna AE, Thilaganathan N, Moghaddam S, Evans CM, Li H, Cai WW, Sato M, Minna JD, Wu H, Creighton CJ, Demayo FJ, Wistuba, II, Kurie JM: Pten Inactivation Accelerates Oncogenic K-ras-Initiated Tumorigenesis in a Mouse Model of Lung Cancer. Cancer Research 68:1119-1127, 2008
Kwei KA, Kim YH, Girard L, Kao J, Pacyna-Gengelbach M, Salari K, Lee J, Choi YL, Sato M, Wang P, Hernandez-Boussard T, Gazdar AF, Petersen I, Minna JD, Pollack JR: Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer. Oncogene 27:3635-40, 2008
Johnson RL, Huang W, Jadhav A, Austin CP, Inglese J, Martinez ED: A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression. Analytical Biochemistry 375:237-248, 2008
Jagadeeswaran R, Surawska H, Krishnaswamy S, Janamanchi V, Mackinnon AC, Seiwert TY, Loganathan S, Kanteti R, Reichman T, Nallasura V, Schwartz S, Faoro L, Wang YC, Girard L, Tretiakova MS, Ahmed S, Zumba O, Soulii L, Bindokas VP, Szeto LL, Gordon GJ, Bueno R, Sugarbaker D, Lingen MW, Sattler M, Krausz T, Vigneswaran W, Natarajan V, Minna J, Vokes EE, Ferguson MK, Husain AN, Salgia R: Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion. Cancer Research 68:132-42, 2008
Gao B, Xie XJ, Huang C, Shames DS, Chen TT, Lewis CM, Bian A, Zhang B, Olopade OI, Garber JE, Euhus DM, Tomlinson GE, Minna JD: RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers. Cancer Research 68:22-5, 2008
Prudkin L, Behrens C, Liu DD, Zhou X, Ozburn NC, Bekele BN, Minna JD, Moran C, Roth JA, Ji L, Wistuba, II: Loss and reduction of FUS1 protein expression is a frequent phenomenon in the pathogenesis of lung cancer. Clinical Cancer Research 14:41-7, 2008
Eckstein N, Servan K, Girard L, Cai D, von Jonquieres G, Jaehde U, Kassack MU, Gazdar AF, Minna JD, Royer HD: Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells. Journal of Biological Chemistry 283:739-50, 2008
Minna JD, Schiller J: Neoplasms of the Lung, in Kasper D, Fauci A, Longo DL, et al (eds): Harrison's Principles of Internal Medicine (ed 17th). New York, McGraw-Hill, 2008, pp 551-562
Lam S, Standish B, Baldwin C, McWilliams A, Leriche J, Gazdar A, Vitkin AI, Yang V, Ikeda N, Macaulay C: In vivo Optical Coherence Tomography Imaging of Preinvasive Bronchial Lesions. Clinical Cancer Research 14:2006-11, 2008
Lin H, Feng Z, Yu Y, Zheng Y, Shivapurkar N, Gazdar AF: Application of multidimensional selective item response regression model for studying multiple gene methylation in SV40 oncogenic pathways. Journal of the American Statistical Association 103:201-211, 2008
Soh J, Toyooka S, Ichihara S, Asano H, Kobayashi N, Suehisa H, Otani H, Yamamoto H, Ichimura K, Kiura K, Gazdar AF, Date H: Sequential molecular changes during multistage pathogenesis of small peripheral adenocarcinomas of the lung. Journal of Thoracic Oncology 3:340-7, 2008
2007
Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L, Chitale D, Motoi N, Szoke J, Broderick S, Balak M, Chang WC, Yu CJ, Gazdar A, Pass H, Rusch V, Gerald W, Huang SF, Yang PC, Miller V, Ladanyi M, Yang CH, Pao W: MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proceedings of the National Academy of Sciences U S A 104:20932-7, 2007
Qiao X, Lu JY, Hofmann SL: Gene expression profiling in a mouse model of infantile neuronal ceroid lipofuscinosis reveals upregulation of immediate early genes and mediators of the inflammatory response. BMC Neuroscience 8:95, 2007
Petersen SL, Wang L, Yalcin-Chin A, Li L, Peyton M, Minna J, Harran P, Wang X: Autocrine TNFalpha Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis. Cancer Cell 12:445-456, 2007
Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA, Kraja A, Johnson LA, Shah K, Sato M, Thomas RK, Barletta JA, Borecki IB, Broderick S, Chang AC, Chiang DY, Chirieac LR, Cho J, Fujii Y, Gazdar AF, Giordano T, Greulich H, Hanna M, Johnson BE, Kris MG, Lash A, Lin L, Lindeman N, Mardis ER, McPherson JD, Minna JD, Morgan MB, Nadel M, Orringer MB, Osborne JR, Ozenberger B, Ramos AH, Robinson J, Roth JA, Rusch V, Sasaki H, Shepherd F, Sougnez C, Spitz MR, Tsao MS, Twomey D, Verhaak RG, Weinstock GM, Wheeler DA, Winckler W, Yoshizawa A, Yu S, Zakowski MF, Zhang Q, Beer DG, Wistuba, II, Watson MA, Garraway LA, Ladanyi M, Travis WD, Pao W, Rubin MA, Gabriel SB, Gibbs RA, Varmus HE, Wilson RK, Lander ES, Meyerson M: Characterizing the cancer genome in lung adenocarcinoma. Nature 450:893-8, 2007
Jayachandran G, Sazaki JI, Nishizaki M, Xu K, Girard L, Minna JD, Roth JA, Ji L: Fragile Histidine Triad Mediated Tumor Suppression of Lung Cancer by Targeting Multiple Components of the Ras/Rho GTPase Molecular Switch. Cancer Research 67:10379-10388, 2007
Martinez ED, Botos J, Dohoney KM, Geiman TM, Kolla SS, Olivera A, Qiu Y, Rayasam GV, Stavreva DA, Cohen-Fix O: Falling off the academic bandwagon. Women are more likely to quit at the postdoc to principal investigator transition. EMBO Report 8:977-81, 2007
Hittelman WN, Liu DD, Kurie JM, Lotan R, Lee JS, Khuri F, Ibarguen H, Morice RC, Walsh G, Roth JA, Minna J, Ro JY, Broxson A, Hong WK, Lee JJ: Proliferative changes in the bronchial epithelium of former smokers treated with retinoids. Journal of the National Cancer Institute 99:1603-12, 2007
Liang Y, Besch-Williford C, Brekken RA, Hyder SM: Progestin-dependent progression of human breast tumor xenografts: a novel model for evaluating antitumor therapeutics. Cancer Research 67:9929-36, 2007
Sun S, Schiller JH, Spinola M, Minna JD: New molecularly targeted therapies for lung cancer. Journal of Clinical Investigation 117:2740-50, 2007
Parmigiani G, Chen S, Iversen ES, Jr., Friebel TM, Finkelstein DM, Anton-Culver H, Ziogas A, Weber BL, Eisen A, Malone KE, Daling JR, Hsu L, Ostrander EA, Peterson LE, Schildkraut JM, Isaacs C, Corio C, Leondaridis L, Tomlinson G, Amos CI, Strong LC, Berry DA, Weitzel JN, Sand S, Dutson D, Kerber R, Peshkin BN, Euhus DM: Validity of models for predicting BRCA1 and BRCA2 mutations. Annals of Internal Medicine 147:441-50, 2007
Chesler L, Goldenberg DD, Seales IT, Satchi-Fainaro R, Grimmer M, Collins R, Struett C, Nguyen KN, Kim G, Tihan T, Bao Y, Brekken RA, Bergers G, Folkm