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Huffman, K.E., Carstens, R., Martinez, E.D., A Subset of Nuclear Receptors are Uniquely Expressed in Uveal Melanoma Cells. Front Endocrinol (Lausanne), 6: 93, 2015

Kirane, A., Ludwig, K.F., Sorrelle, N., Haaland, G., Sandal, T., Ranaweera, R., Toombs, J.E., Wang, M., Dineen, S.P., Micklem, D., Dellinger, M.T., Lorens, J.B., Brekken, R.A., Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis. Cancer Res, 75: 3699-705, 2015

Lu, J.Y., Nelvagal, H.R., Wang, L., Birnbaum, S.G., Cooper, J.D., Hofmann, S.L., Intrathecal enzyme replacement therapy improves motor function and survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis. Mol Genet Metab, 116: 98-105, 2015

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Moore, Z., Chakrabarti, G., Luo, X., Ali, A., Hu, Z., Fattah, F.J., Vemireddy, R., DeBerardinis, R.J., Brekken, R.A., Boothman, D.A., NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by beta-lapachone. Cell Death Dis, 6: e1599, 2015

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Dbouk, H.A., Weil, L.M., Perera, G.K., Dellinger, M.T., Pearson, G., Brekken, R.A., Cobb, M.H., Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK. Proc Natl Acad Sci U S A, 111: 15999-6004, 2014

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Mateo, F., Meca-Cortes, O., Celia-Terrassa, T., Fernandez, Y., Abasolo, I., Sanchez-Cid, L., Bermudo, R., Sagasta, A., Rodriguez-Carunchio, L., Pons, M., Canovas, V., Marin-Aguilera, M., Mengual, L., Alcaraz, A., Schwartz, S., Jr., Mellado, B., Aguilera, K.Y., Brekken, R., Fernandez, P.L., Paciucci, R., Thomson, T.M., SPARC mediates metastatic cooperation between CSC and non-CSC prostate cancer cell subpopulations. Mol Cancer, 13: 237, 2014

Augustyn, A., Borromeo, M., Wang, T., Fujimoto, J., Shao, C., Dospoy, P.D., Lee, V., Tan, C., Sullivan, J.P., Larsen, J.E., Girard, L., Behrens, C., Wistuba, II, Xie, Y., Cobb, M.H., Gazdar, A.F., Johnson, J.E., Minna, J.D., ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers. Proc Natl Acad Sci U S A, 111: 14788-93, 2014

Barone, A., Sengupta, R., Warrington, N.M., Smith, E., Wen, P.Y., Brekken, R.A., Romagnoli, B., Douglas, G., Chevalier, E., Bauer, M.P., Dembowsky, K., Piwnica-Worms, D., Rubin, J.B., Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma. Oncotarget, 5: 9811-22, 2014

Tran, T.A., Wichterman-Kouznetsova, J., Varghese, D., Huang, R., Huang, W., Becker, M., Austin, C.P., Inglese, J., Johnson, R.L., Martinez, E.D., Identification of small molecule modulators of gene transcription with anticancer activity. ACS Chem Biol, 9: 2603-11, 2014

Kim, J., Hsia, E.Y., Kim, J., Sever, N., Beachy, P.A., Zheng, X., Simultaneous measurement of smoothened entry into and exit from the primary cilium. PLoS One, 9: e104070, 2014

Ostapoff, K.T., Cenik, B.K., Wang, M., Ye, R., Xu, X., Nugent, D., Hagopian, M.M., Topalovski, M., Rivera, L.B., Carroll, K.D., Brekken, R.A., Neutralizing murine TGFbetaR2 promotes a differentiated tumor cell phenotype and inhibits pancreatic cancer metastasis. Cancer Res, 74: 4996-5007, 2014

Taguchi, A., Taylor, A.D., Rodriguez, J., Celiktas, M., Liu, H., Ma, X., Zhang, Q., Wong, C.H., Chin, A., Girard, L., Behrens, C., Lam, W.L., Lam, S., Minna, J.D., Wistuba, II, Gazdar, A.F., Hanash, S.M., A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets. Cancer Res, 74: 4694-705, 2014

Mathur, A., Ware, C., Davis, L., Gazdar, A., Pan, B.S., Lutterbach, B., FGFR2 is amplified in the NCI-H716 colorectal cancer cell line and is required for growth and survival. PLoS One, 9: e98515, 2014

Shao, C., Sullivan, J.P., Girard, L., Augustyn, A., Yenerall, P., Rodriguez-Canales, J., Liu, H., Behrens, C., Shay, J.W., Wistuba, II, Minna, J.D., Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway. Clin Cancer Res, 20: 4154-66, 2014

Gazdar, A., Robinson, L., Oliver, D., Xing, C., Travis, W.D., Soh, J., Toyooka, S., Watumull, L., Xie, Y., Kernstine, K., Schiller, J.H., Hereditary lung cancer syndrome targets never smokers with germline EGFR gene T790M mutations. J Thorac Oncol, 9: 456-63, 2014

Leroy, B., Girard, L., Hollestelle, A., Minna, J.D., Gazdar, A.F., Soussi, T., Analysis of TP53 mutation status in human cancer cell lines: a reassessment. Hum Mutat, 35: 756-65, 2014

Hubers, A.J., van der Drift, M.A., Prinsen, C.F., Witte, B.I., Wang, Y., Shivapurkar, N., Stastny, V., Bolijn, A.S., Hol, B.E., Feng, Z., Dekhuijzen, P.N., Gazdar, A.F., Thunnissen, E., Methylation analysis in spontaneous sputum for lung cancer diagnosis. Lung Cancer, 84: 127-33, 2014

Dellinger, M.T., Garg, N., Olsen, B.R., Viewpoints on vessels and vanishing bones in Gorham-Stout disease. Bone, 63: 47-52, 2014

Yang, L., Kwon, J., Popov, Y., Gajdos, G.B., Ordog, T., Brekken, R.A., Mukhopadhyay, D., Schuppan, D., Bi, Y., Simonetto, D., Shah, V.H., Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. Gastroenterology, 146: 1339-50 e1, 2014

Kim, D.J., Kim, J., Spaunhurst, K., Montoya, J., Khodosh, R., Chandra, K., Fu, T., Gilliam, A., Molgo, M., Beachy, P.A., Tang, J.Y., Open-Label, Exploratory Phase II Trial of Oral Itraconazole for the Treatment of Basal Cell Carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014

Delgado, O., Batten, K.G., Richardson, J.A., Xie, X.J., Gazdar, A.F., Kaisani, A.A., Girard, L., Behrens, C., Suraokar, M., Fasciani, G., Wright, W.E., Story, M.D., Wistuba, II, Minna, J.D., Shay, J.W., Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer. Clin Cancer Res, 20: 1610-22, 2014

D'Amico, G., Korhonen, E.A., Anisimov, A., Zarkada, G., Holopainen, T., Hagerling, R., Kiefer, F., Eklund, L., Sormunen, R., Elamaa, H., Brekken, R.A., Adams, R.H., Koh, G.Y., Saharinen, P., Alitalo, K., Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. J Clin Invest, 124: 824-34, 2014

Gazdar, A.F., EGFR mutations in lung cancer: different frequencies for different folks. J Thorac Oncol, 9: 139-40, 2014

Brekken, R.A., Faulty ECM signaling facilitates autoimmune lymphomagenesis. Cancer Discov, 4: 25-6, 2014

Song, S.Y., Das, A.K., Minna, J.D., Comparison between concurrent and sequential chemoradiation for non-small cell lung cancer. Oncol Lett, 7: 307-310, 2014

Aguilera, K.Y., Rivera, L.B., Hur, H., Carbon, J.G., Toombs, J.E., Goldstein, C.D., Dellinger, M.T., Castrillon, D.H., Brekken, R.A., Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma. Cancer Res, 74: 1032-44, 2014

Zaganjor, E., Osborne, J.K., Weil, L.M., Diaz-Martinez, L.A., Gonzales, J.X., Singel, S.M., Larsen, J.E., Girard, L., Minna, J.D., Cobb, M.H., Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells. Oncogene, 33: 5457-66, 2014

Wilson, I.M., Vucic, E.A., Enfield, K.S., Thu, K.L., Zhang, Y.A., Chari, R., Lockwood, W.W., Radulovich, N., Starczynowski, D.T., Banath, J.P., Zhang, M., Pusic, A., Fuller, M., Lonergan, K.M., Rowbotham, D., Yee, J., English, J.C., Buys, T.P., Selamat, S.A., Laird-Offringa, I.A., Liu, P., Anderson, M., You, M., Tsao, M.S., Brown, C.J., Bennewith, K.L., MacAulay, C.E., Karsan, A., Gazdar, A.F., Lam, S., Lam, W.L., EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. Oncogene, 33: 4464-73, 2014

Ribeiro, N., Sousa, S.R., Brekken, R.A., Monteiro, F.J., Role of SPARC in bone remodeling and cancer-related bone metastasis. J Cell Biochem, 115: 17-26, 2014

Du, L., Zhao, Z., Ma, X., Hsiao, T.H., Chen, Y., Young, E., Suraokar, M., Wistuba, I., Minna, J.D., Pertsemlidis, A., miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer. Oncogene, 33: 4307-15, 2014

Aguilera, K.Y., Brekken, R.A., Recruitment and retention: factors that affect pericyte migration. Cell Mol Life Sci, 71: 299-309, 2014

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Wu, Q., Ishikawa, T., Sirianni, R., Tang, H., McDonald, J.G., Yuhanna, I.S., Thompson, B., Girard, L., Mineo, C., Brekken, R.A., Umetani, M., Euhus, D.M., Xie, Y., Shaul, P.W., 27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth. Cell Rep, 5: 637-45, 2013

Pikor, L.A., Lockwood, W.W., Thu, K.L., Vucic, E.A., Chari, R., Gazdar, A.F., Lam, S., Lam, W.L., YEATS4 is a novel oncogene amplified in non-small cell lung cancer that regulates the p53 pathway. Cancer Res, 73: 7301-12, 2013

Cooper, W.A., Lam, D.C., O'Toole, S.A., Minna, J.D., Molecular biology of lung cancer. J Thorac Dis, 5 Suppl 5: S479-90, 2013

Davidson, M.R., Gazdar, A.F., Clarke, B.E., The pivotal role of pathology in the management of lung cancer. J Thorac Dis, 5 Suppl 5: S463-78, 2013

Meng, J., Majidi, M., Fang, B., Ji, L., Bekele, B.N., Minna, J.D., Roth, J.A., The tumor suppressor gene TUSC2 (FUS1) sensitizes NSCLC to the AKT inhibitor MK2206 in LKB1-dependent manner. PLoS One, 8: e77067, 2013

Bu, D., Lewis, C.M., Sarode, V., Chen, M., Ma, X., Lazorwitz, A.M., Rao, R., Leitch, M., Moldrem, A., Andrews, V., Gazdar, A., Euhus, D., Identification of breast cancer DNA methylation markers optimized for fine-needle aspiration samples. Cancer Epidemiol Biomarkers Prev, 22: 2212-21, 2013

Tam, K.W., Zhang, W., Soh, J., Stastny, V., Chen, M., Sun, H., Thu, K., Rios, J.J., Yang, C., Marconett, C.N., Selamat, S.A., Laird-Offringa, I.A., Taguchi, A., Hanash, S., Shames, D., Ma, X., Zhang, M.Q., Lam, W.L., Gazdar, A., CDKN2A/p16 inactivation mechanisms and their relationship to smoke exposure and molecular features in non-small-cell lung cancer. J Thorac Oncol, 8: 1378-88, 2013

Huffman, K., Martinez, E.D., Pre-clinical studies of epigenetic therapies targeting histone modifiers in lung cancer. Front Oncol, 3: 235, 2013

Wei, Y., Zou, Z., Becker, N., Anderson, M., Sumpter, R., Xiao, G., Kinch, L., Koduru, P., Christudass, C.S., Veltri, R.W., Grishin, N.V., Peyton, M., Minna, J., Bhagat, G., Levine, B., EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance. Cell, 154: 1269-84, 2013

Dellinger, M.T., Meadows, S.M., Wynne, K., Cleaver, O., Brekken, R.A., Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature. PLoS One, 8: e74686, 2013

Coe, B.P., Thu, K.L., Aviel-Ronen, S., Vucic, E.A., Gazdar, A.F., Lam, S., Tsao, M.S., Lam, W.L., Genomic deregulation of the E2F/Rb pathway leads to activation of the oncogene EZH2 in small cell lung cancer. PLoS One, 8: e71670, 2013

Gazdar, A.F., Minna, J.D., Precision medicine for cancer patients: lessons learned and the path forward. J Natl Cancer Inst, 105: 1262-3, 2013

Osborne, J.K., Larsen, J.E., Gonzales, J.X., Shames, D.S., Sato, M., Wistuba, II, Girard, L., Minna, J.D., Cobb, M.H., NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition. Oncogenesis, 2: e63, 2013

Myers, B.R., Sever, N., Chong, Y.C., Kim, J., Belani, J.D., Rychnovsky, S., Bazan, J.F., Beachy, P.A., Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response. Developmental Cell, 26: 346-57, 2013

Villalta, S.A., Lang, J., Kubeck, S., Kabre, B., Szot, G.L., Calderon, B., Wasserfall, C., Atkinson, M.A., Brekken, R.A., Pullen, N., Arch, R.H., Bluestone, J.A., Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function. Diabetes, 62: 2870-8, 2013

Dai, B., Yoo, S.Y., Bartholomeusz, G., Graham, R.A., Majidi, M., Yan, S., Meng, J., Ji, L., Coombes, K., Minna, J.D., Fang, B., Roth, J.A., KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer. Cancer Res, 73: 5532-43, 2013

Wang, L., Chang, J., Varghese, D., Dellinger, M., Kumar, S., Best, A.M., Ruiz, J., Bruick, R., Pena-Llopis, S., Xu, J., Babinski, D.J., Frantz, D.E., Brekken, R.A., Quinn, A.M., Simeonov, A., Easmon, J., Martinez, E.D., A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun, 4: 2035, 2013

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Ma, X., Wang, Y.W., Zhang, M.Q., Gazdar, A.F., DNA methylation data analysis and its application to cancer research. Epigenomics, 5: 301-16, 2013

Bennett, K.M., Afanador, M.D., Lal, C.V., Xu, H., Persad, E., Legan, S.K., Chenaux, G., Dellinger, M., Savani, R.C., Dravis, C., Henkemeyer, M., Schwarz, M.A., Ephrin-B2 reverse signaling increases alpha5beta1 integrin-mediated fibronectin deposition and reduces distal lung compliance. Am J Respir Cell Mol Biol, 49: 680-7, 2013

Kutluk Cenik, B., Ostapoff, K.T., Gerber, D.E., Brekken, R.A., BIBF 1120 (nintedanib), a triple angiokinase inhibitor, induces hypoxia but not EMT and blocks progression of preclinical models of lung and pancreatic cancer. Mol Cancer Ther, 12: 992-1001, 2013

Ding, L.H., Park, S., Peyton, M., Girard, L., Xie, Y., Minna, J.D., Story, M.D., Distinct transcriptome profiles identified in normal human bronchial epithelial cells after exposure to gamma-rays and different elemental particles of high Z and energy. BMC Genomics, 14: 372, 2013

Hooda, J., Cadinu, D., Alam, M.M., Shah, A., Cao, T.M., Sullivan, L.A., Brekken, R., Zhang, L., Enhanced heme function and mitochondrial respiration promote the progression of lung cancer cells. PLoS One, 8: e63402, 2013

Ostapoff, K.T., Awasthi, N., Cenik, B.K., Hinz, S., Dredge, K., Schwarz, R.E., Brekken, R.A., PG545, an angiogenesis and heparanase inhibitor, reduces primary tumor growth and metastasis in experimental pancreatic cancer. Mol Cancer Ther, 12: 1190-201, 2013

Osborne, J.K., Larsen, J.E., Shields, M.D., Gonzales, J.X., Shames, D.S., Sato, M., Kulkarni, A., Wistuba, II, Girard, L., Minna, J.D., Cobb, M.H., NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM. Proc Natl Acad Sci U S A, 110: 6524-9, 2013

Shien, K., Toyooka, S., Yamamoto, H., Soh, J., Jida, M., Thu, K.L., Hashida, S., Maki, Y., Ichihara, E., Asano, H., Tsukuda, K., Takigawa, N., Kiura, K., Gazdar, A.F., Lam, W.L., Miyoshi, S., Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells. Cancer Res, 73: 3051-61, 2013

Currier, M.A., Eshun, F.K., Sholl, A., Chernoguz, A., Crawford, K., Divanovic, S., Boon, L., Goins, W.F., Frischer, J.S., Collins, M.H., Leddon, J.L., Baird, W.H., Haseley, A., Streby, K.A., Wang, P.Y., Hendrickson, B.W., Brekken, R.A., Kaur, B., Hildeman, D., Cripe, T.P., VEGF blockade enables oncolytic cancer virotherapy in part by modulating intratumoral myeloid cells. Mol Ther, 21: 1014-23, 2013

Chatterjee, S., Heukamp, L.C., Siobal, M., Schottle, J., Wieczorek, C., Peifer, M., Frasca, D., Koker, M., Konig, K., Meder, L., Rauh, D., Buettner, R., Wolf, J., Brekken, R.A., Neumaier, B., Christofori, G., Thomas, R.K., Ullrich, R.T., Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer. J Clin Invest, 123: 1732-40, 2013

Sato, M., Larsen, J.E., Lee, W., Sun, H., Shames, D.S., Dalvi, M.P., Ramirez, R.D., Tang, H., DiMaio, J.M., Gao, B., Xie, Y., Wistuba, II, Gazdar, A.F., Shay, J.W., Minna, J.D., Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations. Mol Cancer Res, 11: 638-50, 2013

Kim, H.S., Minna, J.D., White, M.A., GWAS meets TCGA to illuminate mechanisms of cancer predisposition. Cell, 152: 387-9, 2013

Konstantinidou, G., Ramadori, G., Torti, F., Kangasniemi, K., Ramirez, R.E., Cai, Y., Behrens, C., Dellinger, M.T., Brekken, R.A., Wistuba, II, Heguy, A., Teruya-Feldstein, J., Scaglioni, P.P., RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas. Cancer Discov, 3: 444-57, 2013

Tang, H., Xiao, G., Behrens, C., Schiller, J., Allen, J., Chow, C.W., Suraokar, M., Corvalan, A., Mao, J., White, M.A., Wistuba, II, Minna, J.D., Xie, Y., A 12-gene set predicts survival benefits from adjuvant chemotherapy in non-small cell lung cancer patients. Clin Cancer Res, 19: 1577-86, 2013

Said, N., Frierson, H.F., Sanchez-Carbayo, M., Brekken, R.A., Theodorescu, D., Loss of SPARC in bladder cancer enhances carcinogenesis and progression. J Clin Invest, 123: 751-66, 2013

Kim, J., Aftab, B.T., Tang, J.Y., Kim, D., Lee, A.H., Rezaee, M., Kim, J., Chen, B., King, E.M., Borodovsky, A., Riggins, G.J., Epstein, E.H., Jr., Beachy, P.A., Rudin, C.M., Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell, 23: 23-34, 2013

Li, X., Zhou, Q., Hanus, J., Anderson, C., Zhang, H., Dellinger, M., Brekken, R., Wang, S., Inhibition of multiple pathogenic pathways by histone deacetylase inhibitor SAHA in a corneal alkali-burn injury model. Mol Pharm, 10: 307-18, 2013

Yoshida, K., Sato, M., Hase, T., Elshazley, M., Yamashita, R., Usami, N., Taniguchi, T., Yokoi, K., Nakamura, S., Kondo, M., Girard, L., Minna, J.D., Hasegawa, Y., TIMELESS is overexpressed in lung cancer and its expression correlates with poor patient survival. Cancer Sci, 104: 171-7, 2013

Byers, L.A., Diao, L., Wang, J., Saintigny, P., Girard, L., Peyton, M., Shen, L., Fan, Y., Giri, U., Tumula, P.K., Nilsson, M.B., Gudikote, J., Tran, H., Cardnell, R.J., Bearss, D.J., Warner, S.L., Foulks, J.M., Kanner, S.B., Gandhi, V., Krett, N., Rosen, S.T., Kim, E.S., Herbst, R.S., Blumenschein, G.R., Lee, J.J., Lippman, S.M., Ang, K.K., Mills, G.B., Hong, W.K., Weinstein, J.N., Wistuba, II, Coombes, K.R., Minna, J.D., Heymach, J.V., An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance. Clin Cancer Res, 19: 279-90, 2013

Travis, W.D., Brambilla, E., Noguchi, M., Nicholson, A.G., Geisinger, K., Yatabe, Y., Ishikawa, Y., Wistuba, I., Flieder, D.B., Franklin, W., Gazdar, A., Hasleton, P.S., Henderson, D.W., Kerr, K.M., Petersen, I., Roggli, V., Thunnissen, E., Tsao, M., Diagnosis of lung cancer in small biopsies and cytology: implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. Arch Pathol Lab Med, 137: 668-84, 2013

Dasgupta, S., Jang, J.S., Shao, C., Mukhopadhyay, N.D., Sokhi, U.K., Das, S.K., Brait, M., Talbot, C., Yung, R.C., Begum, S., Westra, W.H., Hoque, M.O., Yang, P., Yi, J.E., Lam, S., Gazdar, A.F., Fisher, P.B., Jen, J., Sidransky, D., SH3GL2 is frequently deleted in non-small cell lung cancer and downregulates tumor growth by modulating EGFR signaling. J Mol Med (Berl), 91: 381-93, 2013

Sunaga, N., Kaira, K., Imai, H., Shimizu, K., Nakano, T., Shames, D.S., Girard, L., Soh, J., Sato, M., Iwasaki, Y., Ishizuka, T., Gazdar, A.F., Minna, J.D., Mori, M., Oncogenic KRAS-induced epiregulin overexpression contributes to aggressive phenotype and is a promising therapeutic target in non-small-cell lung cancer. Oncogene, 32: 4034-42, 2013

Travis, W.D., Brambilla, E., Noguchi, M., Nicholson, A.G., Geisinger, K., Yatabe, Y., Ishikawa, Y., Wistuba, I., Flieder, D.B., Franklin, W., Gazdar, A., Hasleton, P.S., Henderson, D.W., Kerr, K.M., Nakatani, Y., Petersen, I., Roggli, V., Thunnissen, E., Tsao, M., Diagnosis of lung adenocarcinoma in resected specimens: implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. Arch Pathol Lab Med, 137: 685-705, 2013


Gazdar, A.F., The evolving role of the pathologist in the management of lung cancer. Lung Cancer Manag, 1: 273-281, 2012

Hu, Y., Martinez, E.D., MacMillan, J.B., Anthraquinones from a marine-derived Streptomyces spinoverrucosus. J Nat Prod, 75: 1759-64, 2012

Liu, J., Lee, W., Jiang, Z., Chen, Z., Jhunjhunwala, S., Haverty, P.M., Gnad, F., Guan, Y., Gilbert, H.N., Stinson, J., Klijn, C., Guillory, J., Bhatt, D., Vartanian, S., Walter, K., Chan, J., Holcomb, T., Dijkgraaf, P., Johnson, S., Koeman, J., Minna, J.D., Gazdar, A.F., Stern, H.M., Hoeflich, K.P., Wu, T.D., Settleman, J., de Sauvage, F.J., Gentleman, R.C., Neve, R.M., Stokoe, D., Modrusan, Z., Seshagiri, S., Shames, D.S., Zhang, Z., Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events. Genome Res, 22: 2315-27, 2012

Byers, L.A., Wang, J., Nilsson, M.B., Fujimoto, J., Saintigny, P., Yordy, J., Giri, U., Peyton, M., Fan, Y.H., Diao, L., Masrorpour, F., Shen, L., Liu, W., Duchemann, B., Tumula, P., Bhardwaj, V., Welsh, J., Weber, S., Glisson, B.S., Kalhor, N., Wistuba, II, Girard, L., Lippman, S.M., Mills, G.B., Coombes, K.R., Weinstein, J.N., Minna, J.D., Heymach, J.V., Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1. Cancer Discov, 2: 798-811, 2012

Rudin, C.M., Durinck, S., Stawiski, E.W., Poirier, J.T., Modrusan, Z., Shames, D.S., Bergbower, E.A., Guan, Y., Shin, J., Guillory, J., Rivers, C.S., Foo, C.K., Bhatt, D., Stinson, J., Gnad, F., Haverty, P.M., Gentleman, R., Chaudhuri, S., Janakiraman, V., Jaiswal, B.S., Parikh, C., Yuan, W., Zhang, Z., Koeppen, H., Wu, T.D., Stern, H.M., Yauch, R.L., Huffman, K.E., Paskulin, D.D., Illei, P.B., Varella-Garcia, M., Gazdar, A.F., de Sauvage, F.J., Bourgon, R., Minna, J.D., Brock, M.V., Seshagiri, S., Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nat Genet, 44: 1111-6, 2012

Gerber, D.E., Gupta, P., Dellinger, M.T., Toombs, J.E., Peyton, M., Duignan, I., Malaby, J., Bailey, T., Burns, C., Brekken, R.A., Loizos, N., Stromal platelet-derived growth factor receptor alpha (PDGFRalpha) provides a therapeutic target independent of tumor cell PDGFRalpha expression in lung cancer xenografts. Mol Cancer Ther, 11: 2473-82, 2012

Kirane, A., Toombs, J.E., Ostapoff, K., Carbon, J.G., Zaknoen, S., Braunfeld, J., Schwarz, R.E., Burrows, F.J., Brekken, R.A., Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer. Clin Cancer Res, 18: 5031-42, 2012

Thunnissen, E., Beasley, M.B., Borczuk, A.C., Brambilla, E., Chirieac, L.R., Dacic, S., Flieder, D., Gazdar, A., Geisinger, K., Hasleton, P., Ishikawa, Y., Kerr, K.M., Lantejoul, S., Matsuno, Y., Minami, Y., Moreira, A.L., Motoi, N., Nicholson, A.G., Noguchi, M., Nonaka, D., Pelosi, G., Petersen, I., Rekhtman, N., Roggli, V., Travis, W.D., Tsao, M.S., Wistuba, I., Xu, H., Yatabe, Y., Zakowski, M., Witte, B., Kuik, D.J., Reproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma. An international interobserver study. Mod Pathol, 25: 1574-83, 2012

Hezel, A.F., Deshpande, V., Zimmerman, S.M., Contino, G., Alagesan, B., O'Dell, M.R., Rivera, L.B., Harper, J., Lonning, S., Brekken, R.A., Bardeesy, N., TGF-beta and alphavbeta6 integrin act in a common pathway to suppress pancreatic cancer progression. Cancer Res, 72: 4840-5, 2012

Du, L., Subauste, M.C., DeSevo, C., Zhao, Z., Baker, M., Borkowski, R., Schageman, J.J., Greer, R., Yang, C.R., Suraokar, M., Wistuba, II, Gazdar, A.F., Minna, J.D., Pertsemlidis, A., miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers. PLoS One, 7: e39167, 2012

Yao, Y., Fan, Y., Wu, J., Wan, H., Wang, J., Lam, S., Lam, W.L., Girard, L., Gazdar, A.F., Wu, Z., Zhou, Q., Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis. Biochem Biophys Res Commun, 423: 613-9, 2012

Hu, J., Lu, J.Y., Wong, A.M., Hynan, L.S., Birnbaum, S.G., Yilmaz, D.S., Streit, B.M., Lenartowicz, E.M., Thompson, T.C., Cooper, J.D., Hofmann, S.L., Intravenous high-dose enzyme replacement therapy with recombinant palmitoyl-protein thioesterase reduces visceral lysosomal storage and modestly prolongs survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis. Mol Genet Metab, 107: 213-21, 2012

Jeong, Y., Xie, Y., Lee, W., Bookout, A.L., Girard, L., Raso, G., Behrens, C., Wistuba, II, Gadzar, A.F., Minna, J.D., Mangelsdorf, D.J., Research resource: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer. Mol Endocrinol, 26: 1443-54, 2012

Kirane, A., Toombs, J.E., Larsen, J.E., Ostapoff, K.T., Meshaw, K.R., Zaknoen, S., Brekken, R.A., Burrows, F.J., Epithelial-mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib. Carcinogenesis, 33: 1639-46, 2012

Lockwood, W.W., Wilson, I.M., Coe, B.P., Chari, R., Pikor, L.A., Thu, K.L., Solis, L.M., Nunez, M.I., Behrens, C., Yee, J., English, J., Murray, N., Tsao, M.S., Minna, J.D., Gazdar, A.F., Wistuba, II, MacAulay, C.E., Lam, S., Lam, W.L., Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development. PLoS One, 7: e37775, 2012

Selamat, S.A., Chung, B.S., Girard, L., Zhang, W., Zhang, Y., Campan, M., Siegmund, K.D., Koss, M.N., Hagen, J.A., Lam, W.L., Lam, S., Gazdar, A.F., Laird-Offringa, I.A., Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. Genome Res, 22: 1197-211, 2012

Lynn, K.D., Brekken, R.A., Anti-VEGF therapy revived by c-Met inhibition, but is c-Met the answer? Cancer Discov, 2: 211-3, 2012

Elshazley, M., Sato, M., Hase, T., Yamashita, R., Yoshida, K., Toyokuni, S., Ishiguro, F., Osada, H., Sekido, Y., Yokoi, K., Usami, N., Shames, D.S., Kondo, M., Gazdar, A.F., Minna, J.D., Hasegawa, Y., The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma. Int J Cancer, 131: 2820-31, 2012

Asterholm, I.W., McDonald, J., Blanchard, P.G., Sinha, M., Xiao, Q., Mistry, J., Rutkowski, J.M., Deshaies, Y., Brekken, R.A., Scherer, P.E., Lack of "immunological fitness" during fasting in metabolically challenged animals. J Lipid Res, 53: 1254-67, 2012

Sun, K., Wernstedt Asterholm, I., Kusminski, C.M., Bueno, A.C., Wang, Z.V., Pollard, J.W., Brekken, R.A., Scherer, P.E., Dichotomous effects of VEGF-A on adipose tissue dysfunction. Proc Natl Acad Sci U S A, 109: 5874-9, 2012

Thu, K.L., Vucic, E.A., Chari, R., Zhang, W., Lockwood, W.W., English, J.C., Fu, R., Wang, P., Feng, Z., MacAulay, C.E., Gazdar, A.F., Lam, S., Lam, W.L., Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability. PLoS One, 7: e33003, 2012

Xie, Y., Minna, J.D., A lung cancer molecular prognostic test ready for prime time. Lancet, 379: 785-7, 2012

Arnold, S.A., Rivera, L.B., Carbon, J.G., Toombs, J.E., Chang, C.L., Bradshaw, A.D., Brekken, R.A., Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGFbeta activation. PLoS One, 7: e31384, 2012

Li, G., Guillaud, M., LeRiche, J., McWilliams, A., Gazdar, A., Lam, S., MacAulay, C., Automated sputum cytometry for detection of intraepithelial neoplasias in the lung. Anal Cell Pathol (Amst), 35: 187-201, 2012

Benson, D.D., Beck, A.W., Burdine, M.S., Brekken, R., Silliman, C.C., Barnett, C.C., Jr., Accumulation of pro-cancer cytokines in the plasma fraction of stored packed red cells. J Gastrointest Surg, 16: 460-8, 2012

Allen, J.D., Wang, S., Chen, M., Girard, L., Minna, J.D., Xie, Y., Xiao, G., Probe mapping across multiple microarray platforms. Brief Bioinform, 13: 547-54, 2012

Chang, J., Varghese, D.S., Gillam, M.C., Peyton, M., Modi, B., Schiltz, R.L., Girard, L., Martinez, E.D., Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide. Br J Cancer, 106: 116-25, 2012

Horio, M., Sato, M., Takeyama, Y., Elshazley, M., Yamashita, R., Hase, T., Yoshida, K., Usami, N., Yokoi, K., Sekido, Y., Kondo, M., Toyokuni, S., Gazdar, A.F., Minna, J.D., Hasegawa, Y., Transient but not stable ZEB1 knockdown dramatically inhibits growth of malignant pleural mesothelioma cells. Ann Surg Oncol, 19 Suppl 3: S634-45, 2012

Li, Y., Martin, B.R., Cravatt, B.F., Hofmann, S.L., DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells. J Biol Chem, 287: 523-30, 2012

Dasgupta, S., Soudry, E., Mukhopadhyay, N., Shao, C., Yee, J., Lam, S., Lam, W., Zhang, W., Gazdar, A.F., Fisher, P.B., Sidransky, D., Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression and associated with EGFR gene mutation. J Cell Physiol, 227: 2451-60, 2012

Sunaga, N., Imai, H., Shimizu, K., Shames, D.S., Kakegawa, S., Girard, L., Sato, M., Kaira, K., Ishizuka, T., Gazdar, A.F., Minna, J.D., Mori, M., Oncogenic KRAS-induced interleukin-8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non-small cell lung cancer. Int J Cancer, 130: 1733-44, 2012

Carbone, M., Ly, B.H., Dodson, R.F., Pagano, I., Morris, P.T., Dogan, U.A., Gazdar, A.F., Pass, H.I., Yang, H., Malignant mesothelioma: facts, myths, and hypotheses. J Cell Physiol, 227: 44-58, 2012


Dellinger, M.T., Brekken, R.A., Phosphorylation of Akt and ERK1/2 is required for VEGF-A/VEGFR2-induced proliferation and migration of lymphatic endothelium. PLoS One, 6: e28947, 2011

Gazdar, A.F., Schiller, J.H., Predictive and prognostic factors for non-small cell lung cancer--potholes in the road to the promised land. J Natl Cancer Inst, 103: 1810-1, 2011

Larsen, J.E., Cascone, T., Gerber, D.E., Heymach, J.V., Minna, J.D., Targeted therapies for lung cancer: clinical experience and novel agents. Cancer J, 17: 512-27, 2011

Gazdar, A.F., Zhang, Y.A., Research highlights. Epigenomics, 3: 405-7, 2011

Toyooka, S., Gazdar, A.F., Methylation profiling of lung cancer: a decade of progress. Mol Cancer Ther, 10: 2020, 2011

Larsen, J.E., Minna, J.D., Molecular biology of lung cancer: clinical implications. Clin Chest Med, 32: 703-40, 2011

Lam, D.C., Minna, J.D., How do we safely get people to stop smoking? Cancer Prev Res (Phila), 4: 1724-7, 2011

Greer, R.M., Peyton, M., Larsen, J.E., Girard, L., Xie, Y., Gazdar, A.F., Harran, P., Wang, L., Brekken, R.A., Wang, X., Minna, J.D., SMAC mimetic (JP1201) sensitizes non-small cell lung cancers to multiple chemotherapy agents in an IAP-dependent but TNF-alpha-independent manner. Cancer Res, 71: 7640-8, 2011

Starczynowski, D.T., Lockwood, W.W., Delehouzee, S., Chari, R., Wegrzyn, J., Fuller, M., Tsao, M.S., Lam, S., Gazdar, A.F., Lam, W.L., Karsan, A., TRAF6 is an amplified oncogene bridging the RAS and NF-kappaB pathways in human lung cancer. J Clin Invest, 121: 4095-105, 2011

Taguchi, A., Politi, K., Pitteri, S.J., Lockwood, W.W., Faca, V.M., Kelly-Spratt, K., Wong, C.H., Zhang, Q., Chin, A., Park, K.S., Goodman, G., Gazdar, A.F., Sage, J., Dinulescu, D.M., Kucherlapati, R., Depinho, R.A., Kemp, C.J., Varmus, H.E., Hanash, S.M., Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell, 20: 289-99, 2011

Shay, J.W., Cucinotta, F.A., Sulzman, F.M., Coleman, C.N., Minna, J.D., From mice and men to earth and space: joint NASA-NCI workshop on lung cancer risk resulting from space and terrestrial radiation. Cancer Res, 71: 6926-9, 2011

Nomura, M., Fukuda, T., Fujii, K., Kawamura, T., Tojo, H., Kihara, M., Bando, Y., Gazdar, A.F., Tsuboi, M., Oshiro, H., Nagao, T., Ohira, T., Ikeda, N., Gotoh, N., Kato, H., Marko-Varga, G., Nishimura, T., Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study. J Clin Bioinforma, 1: 23, 2011

Girotti, M.R., Fernandez, M., Lopez, J.A., Camafeita, E., Fernandez, E.A., Albar, J.P., Benedetti, L.G., Valacco, M.P., Brekken, R.A., Podhajcer, O.L., Llera, A.S., SPARC promotes cathepsin B-mediated melanoma invasiveness through a collagen I/alpha2beta1 integrin axis. J Invest Dermatol, 131: 2438-47, 2011

Rivera, L.B., Bradshaw, A.D., Brekken, R.A., The regulatory function of SPARC in vascular biology. Cell Mol Life Sci, 68: 3165-73, 2011

Thu, K.L., Pikor, L.A., Chari, R., Wilson, I.M., Macaulay, C.E., English, J.C., Tsao, M.S., Gazdar, A.F., Lam, S., Lam, W.L., Lockwood, W.W., Genetic disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer. J Thorac Oncol, 6: 1521-9, 2011

Zhang, Y.A., Maitra, A., Hsieh, J.T., Rudin, C.M., Peacock, C.D., Karikari, C., Brekken, R.A., Stastny, V., Gao, B., Girard, L., Wistuba, I., Frenkel, E., Minna, J.D., Gazdar, A.F., Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts. Cancer Biol Ther, 12: 617-28, 2011

Xie, Y., Xiao, G., Coombes, K.R., Behrens, C., Solis, L.M., Raso, G., Girard, L., Erickson, H.S., Roth, J., Heymach, J.V., Moran, C., Danenberg, K., Minna, J.D., Wistuba, II, Robust gene expression signature from formalin-fixed paraffin-embedded samples predicts prognosis of non-small-cell lung cancer patients. Clin Cancer Res, 17: 5705-14, 2011

Rivera, L.B., Brekken, R.A., SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-beta1 activity. J Cell Biol, 193: 1305-19, 2011

Harris, B.S., Zhang, Y., Card, L., Rivera, L.B., Brekken, R.A., Bradshaw, A.D., SPARC regulates collagen interaction with cardiac fibroblast cell surfaces. Am J Physiol Heart Circ Physiol, 301: H841-7, 2011

Hase, T., Sato, M., Yoshida, K., Girard, L., Takeyama, Y., Horio, M., Elshazley, M., Oguri, T., Sekido, Y., Shames, D.S., Gazdar, A.F., Minna, J.D., Kondo, M., Hasegawa, Y., Pivotal role of epithelial cell adhesion molecule in the survival of lung cancer cells. Cancer Sci, 102: 1493-500, 2011

Gazdar, A.F., Tyrosine kinase inhibitors and epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer: to test or not to test? Medicine (Baltimore), 90: 168-70, 2011

Sierko, E., Wojtukiewicz, M.Z., Zimnoch, L., Thorpe, P.E., Brekken, R.A., Kisiel, W., Co-localization of prothrombin fragment F1+2 and VEGF-R2-bound VEGF in human colon cancer. Anticancer Res, 31: 843-7, 2011

Ou, Y.H., Torres, M., Ram, R., Formstecher, E., Roland, C., Cheng, T., Brekken, R., Wurz, R., Tasker, A., Polverino, T., Tan, S.L., White, M.A., TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation. Mol Cell, 41: 458-70, 2011

Galindo, C.L., McIver, L.J., Tae, H., McCormick, J.F., Skinner, M.A., Hoeschele, I., Lewis, C.M., Minna, J.D., Boothman, D.A., Garner, H.R., Sporadic breast cancer patients' germline DNA exhibit an AT-rich microsatellite signature. Genes Chromosomes Cancer, 50: 275-83, 2011

Sunaga, N., Shames, D.S., Girard, L., Peyton, M., Larsen, J.E., Imai, H., Soh, J., Sato, M., Yanagitani, N., Kaira, K., Xie, Y., Gazdar, A.F., Mori, M., Minna, J.D., Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy. Mol Cancer Ther, 10: 336-46, 2011

Tang, X., Kadara, H., Behrens, C., Liu, D.D., Xiao, Y., Rice, D., Gazdar, A.F., Fujimoto, J., Moran, C., Varella-Garcia, M., Lee, J.J., Hong, W.K., Wistuba, II, Abnormalities of the TITF-1 lineage-specific oncogene in NSCLC: implications in lung cancer pathogenesis and prognosis. Clin Cancer Res, 17: 2434-43, 2011

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